Cargo-loaded lipid-shielded breakable organosilica nanocages for enhanced drug delivery

Sancho-Albero, María; Rosso, Giada; De Cola, Luisa; Cauda, Valentina

doi:10.1039/d3nr02155f

Cited by 3 publications

(1 citation statement)

References 40 publications

(68 reference statements)

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“…Among the various nanoparticle carriers available, mesoporous silica nanoparticles (MSNs) are ideal for drug delivery in medicine. Despite their numerous advantages, MSNs are limited by poor degradability and a lack of targeted drug delivery properties. , To address these limitations, manganese incorporation has been proposed to promote selective degradation of the MSN network within the tumor microenvironment. This, in turn, facilitates renal clearance .…”

Section: Introductionmentioning

confidence: 99%

Manganese-Doped Mesoporous Magnetic Nanocarriers for Cancer Treatment

Zhou,

He,

Dong

et al. 2024

ACS Appl. Nano Mater.

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To achieve maximum curative effects and minimize side effects in trimodal synergistic cooperative tumor therapies, we propose a strategy of photothermal (PTT)-chemodynamic (CDT)coordinated drug chemotherapy (DT) trimodal synergistic therapy. We designed a multifunctional manganese-doped mesoporous magnetic nanodrug carrier (NH 2 -MMNPs), which was equipped with pullulan oxide to form Schiff base bonds upon loading doxorubicin (DOX), thus creating an oMMNPs/DOX nanoplatform. This nanoplatform exhibits excellent controlled drug release, satisfactory photothermal conversion efficiency under NIR (808 nm) irradiation, good biodegradability, and targeted drug delivery capabilities. It also produces Fenton-like Mn 2+ in response to the highly expressed glutathione (GSH) in the tumor microenvironment, thereby generating chemodynamic therapy. The oMMNPs/DOX demonstrated remarkable killing efficacy in HeLa and MCF-7 cancer cell cultures and reached 84.1% tumor suppression in vivo. The in vitro and in vivo results confirm that this theranostic nanoplatform exhibits excellent biocompatibility and anticancer effects. Therefore, oMMNPs/DOX have potential utility as a magnetically targeted and pH/GSH/NIR triple-triggered drug carrier for synergistic PTT/CDT/DT therapy.

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Section: Introductionmentioning

confidence: 99%