Cargo-less nanoparticles program innate immune cell responses to toll-like receptor activation

Casey, Liam M.; Kakade, Sandeep; Decker, Joseph T.; Rose, Justin A.; Deans, Kyle W; Shea, Lonnie D.; Pearson, Ryan M.

doi:10.1016/j.biomaterials.2019.119333

Cited by 56 publications

(89 citation statements)

References 57 publications

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“…Recently, researchers have introduced biodegradable particles for targeting blood leukocytes as a strategy for the treatment of or to control the severity of many of the inflammatory conditions mentioned above. As an example, biodegradable particles have been used to modulate immune cells to reduce inflammation and disease symp-toms in lupus, spinal cord injury, and sepsis models (4,(15)(16)(17). However, we know little about the specificity of these systems for targeting various leukocyte subpopulations.…”

Section: Introductionmentioning

confidence: 99%

Neutrophils preferentially phagocytose elongated particles—An opportunity for selective targeting in acute inflammatory diseases

et al. 2020

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Polymeric particles have recently been used to modulate the behavior of immune cells in the treatment of various inflammatory conditions. However, there is little understanding of how physical particle parameters affect their specific interaction with different leukocyte subtypes. While particle shape is known to be a crucial factor in their phagocytosis by macrophages, where elongated particles are reported to experience reduced uptake, it remains unclear how shape influences phagocytosis by circulating phagocytes, including neutrophils that are the most abundant leukocyte in human blood. In this study, we investigated the phagocytosis of rod-shaped polymeric particles by human neutrophils relative to other leukocytes. In contrast to macrophages and other mononuclear phagocytes, neutrophils were found to exhibit increased internalization of rods in ex vivo and in vivo experimentation. This result suggests that alteration of particle shape can be used to selectively target neutrophils in inflammatory pathologies where these cells play a substantial role.

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Section: Introductionmentioning

confidence: 99%

Neutrophils preferentially phagocytose elongated particles—An opportunity for selective targeting in acute inflammatory diseases

et al. 2020

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“…Supramolecular nanomaterials are the most common type of nanocarriers for drug delivery [ 227 , 248 ]. Intriguingly, cargo-less PLGA/PLA nanoparticles were shown to diminish inflammatory responses by directly modulating TLR-related pathways, suggesting that the inherent activity of nanomaterials should also be considered in formulating nanodrug delivery systems for sepsis management [ 249 ]. Furthermore, well-designed surface engineering of nanoparticles could also achieve surprising outcomes.…”

Section: Nanotherapeutic Platforms For Sepsis Treatment Through Targementioning

confidence: 99%

Nanoplatforms for Sepsis Management: Rapid Detection/Warning, Pathogen Elimination and Restoring Immune Homeostasis

et al. 2021

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Sepsis, a highly life-threatening organ dysfunction caused by uncontrollable immune responses to infection, is a leading contributor to mortality in intensive care units. Sepsis-related deaths have been reported to account for 19.7% of all global deaths. However, no effective and specific therapeutic for clinical sepsis management is available due to the complex pathogenesis. Concurrently eliminating infections and restoring immune homeostasis are regarded as the core strategies to manage sepsis. Sophisticated nanoplatforms guided by supramolecular and medicinal chemistry, targeting infection and/or imbalanced immune responses, have emerged as potent tools to combat sepsis by supporting more accurate diagnosis and precision treatment. Nanoplatforms can overcome the barriers faced by clinical strategies, including delayed diagnosis, drug resistance and incapacity to manage immune disorders. Here, we present a comprehensive review highlighting the pathogenetic characteristics of sepsis and future therapeutic concepts, summarizing the progress of these well-designed nanoplatforms in sepsis management and discussing the ongoing challenges and perspectives regarding future potential therapies. Based on these state-of-the-art studies, this review will advance multidisciplinary collaboration and drive clinical translation to remedy sepsis."Image missing"

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“…Furthermore, the EPR effect facilitate tumor-target while auxiliary surface modification can help tissue specificity [43,116]. Polymersomes do not induce significant systemic inflammation while some of natural polymers such as hyaluronan and laminin, and synthetic polymers such as negatively charged poly(lactic- [117][118][119]. Moreover, N-(2-hydroxypropyl) methacrylamide and polystyrene are reported to reduce neurotoxicity [120,121].…”

Section: Basic Knowledge On Polymeric Ddsmentioning

confidence: 99%

Advances of Nano-Structured Extended-Release Local Anesthetics

Qin

Huang

et al. 2020

Nanoscale Res Lett

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Extended-release local anesthetics (LAs) have drawn increasing attention with their promising role in improving analgesia and reducing adverse events of LAs. Nano-structured carriers such as liposomes and polymersomes optimally meet the demands of/for extended-release, and have been utilized in drug delivery over decades and showed satisfactory results with extended-release. Based on mature technology of liposomes, EXPAREL, the first approved liposomal LA loaded with bupivacaine, has seen its success in an extended-release form. At the same time, polymersomes has advances over liposomes with complementary profiles, which inspires the emergence of hybrid carriers. This article summarized the recent research successes on nano-structured extended-release LAs, of which liposomal and polymeric are mainstream systems. Furthermore, with continual optimization, drug delivery systems carry properties beyond simple transportation, such as specificity and responsiveness. In the near future, we may achieve targeted delivery and controlled-release properties to satisfy various analgesic requirements.

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Cargo-less nanoparticles program innate immune cell responses to toll-like receptor activation

Cited by 56 publications

References 57 publications

Neutrophils preferentially phagocytose elongated particles—An opportunity for selective targeting in acute inflammatory diseases

Neutrophils preferentially phagocytose elongated particles—An opportunity for selective targeting in acute inflammatory diseases

Nanoplatforms for Sepsis Management: Rapid Detection/Warning, Pathogen Elimination and Restoring Immune Homeostasis

Advances of Nano-Structured Extended-Release Local Anesthetics

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