Caregivers' Self-Reported Absence of Social Support Networks is Related to Treatment Abandonment in Children With Cancer

Ospina-Romero, Monica; Portilla, Carlos Andres; Bravo, Luis Eduardo; Ramírez, Óscar

doi:10.1002/pbc.25919

Cited by 16 publications

(17 citation statements)

References 34 publications

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“…Determinants of TxA in our study (socioeconomic factors, perceived prognosis of disease, concerns about toxicity, and preference for TCAM) are very similar to those worldwide, as established in a global online survey, a systematic review, and other reports . Strategies to reduce abandonment are being studied and increasingly reported . Most centers have adopted overlapping strategies that stem from an increased understanding of the deficiencies common to most LMIC settings.…”

Section: Discussionsupporting

confidence: 56%

“…Most centers have adopted overlapping strategies that stem from an increased understanding of the deficiencies common to most LMIC settings. These usually tend to focus on one or more aspects of support and include setting up of local foundations, enhanced psychosocial support, education of families, subsidized or free treatment, food, transport, and lodging for families, and development of adapted treatment protocols, all of which have been found to decrease rates of TxA . A few reports have also focused on surveillance of treatment adherence and prospective tracking of patients, coupled with timely intervention .…”

Section: Discussionmentioning

confidence: 99%

“…[18][19][20][21][22][23] Strategies to reduce abandonment are being studied and increasingly reported. 9,10,[24][25][26][27][28] Most centers have adopted overlapping strategies that stem from an increased understanding of the deficiencies common to most LMIC settings. These usually tend to focus on one or more aspects of support and include setting up of local foundations, enhanced psychosocial support, education of families, subsidized or free treatment, food, transport, and lodging for families, and development of adapted treatment protocols, all of which have been found to decrease rates of TxA.…”

Section: Discussionmentioning

confidence: 99%

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Holistic support coupled with prospective tracking reduces abandonment in childhood cancers: A report from India

Jatia

Prasad

Paradkar

et al. 2019

Pediatric Blood & Cancer

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Background High cure rates of over 80% in childhood cancers reported from high‐income countries (HICs) are not replicated in low‐ and middle‐income countries (LMICs). Treatment abandonment (TxA) is an important reason for this poorer outcome. We assessed the effect of a holistic support group approach coupled with prospective tracking on TxA in children with cancer in a limited‐resources environment. Methods In 2010, all existing nongovernmental organizations (NGOs) working with childhood cancer at our hospital were brought together to form a pediatric cancer foundation with the aim of providing holistic support to the patient and family, including financial, psychosocial, lodging, educational, and bereavement support. Simultaneously, prospective tracking of all children with a Time‐Responsive Electronic Abandonment Tracking (TREAT) system was also established. The impact of these measures on TxA over the 2009–2016 period was compared using the log‐rank test. Results The annual rate of abandonment reduced from 20% in 2009 to 10.4% in 2010 and 5.2% in 2011. It has been consistently between 3% and 6% from 2012 to 2016 (P −0.04). TxA after the initiation of treatment dropped from 9% in 2009 to 1% in 2016 (P −0.02), while refusal to initiate treatment dropped from 11% to 2.7% (P −0.23) over the same period. Conclusions A holistic support group consisting of the hospital team, as well as existing NGOs and governmental organizations, along with a systematic and prospective tracking system significantly reduced abandonment in a resource‐constrained setting. This cost‐effective holistic support group may be applicable in other LMICs with similar healthcare systems.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Holistic support coupled with prospective tracking reduces abandonment in childhood cancers: A report from India

Jatia

Prasad

Paradkar

et al. 2019

Pediatric Blood & Cancer

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“…The low incidence rates observed in low-resource regions might in part have resulted from underdiagnosis, 13 but our analysis could not quantify its extent. Treatment abandonment, common in LMICs, 14 might also have led to under-registration if identified patients who refused treatment were not sufficiently well described (eg, missing dates or place of residence). Under-ascertainment of diagnosed cases might have resulted from administrative restrictions of access to medical files, political or social instability, competing needs, and inadequate political will, causing a dearth of resources, shortage or volatility of registry personnel, loss of perennial expertise, and missing or broken links with relevant data sources.…”

Section: Discussionmentioning

confidence: 99%

International incidence of childhood cancer, 2001–10: a population-based registry study

Steliarova‐Foucher¹,

Colombet²,

Ries³

et al. 2017

The Lancet Oncology

1,201

890

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SummaryBackgroundCancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer incidence in the past two decades are scarce. This study aimed to provide internationally comparable local data on the incidence of childhood cancer to promote research of causes and implementation of childhood cancer control.MethodsThis population-based registry study, devised by the International Agency for Research on Cancer in collaboration with the International Association of Cancer Registries, collected data on all malignancies and non-malignant neoplasms of the CNS diagnosed before age 20 years in populations covered by high-quality cancer registries with complete data for 2001–10. Incidence rates per million person-years for the 0–14 years and 0–19 years age groups were age-adjusted using the world standard population to provide age-standardised incidence rates (WSRs), using the age-specific incidence rates (ASR) for individual age groups (0–4 years, 5–9 years, 10–14 years, and 15–19 years). All rates were reported for 19 geographical areas or ethnicities by sex, age group, and cancer type. The regional WSRs for children aged 0–14 years were compared with comparable data obtained in the 1980s.FindingsOf 532 invited cancer registries, 153 registries from 62 countries, departments, and territories met quality standards, and contributed data for the entire decade of 2001–10. 385 509 incident cases in children aged 0–19 years occurring in 2·64 billion person-years were included. The overall WSR was 140·6 per million person-years in children aged 0–14 years (based on 284 649 cases), and the most common cancers were leukaemia (WSR 46·4), followed by CNS tumours (WSR 28·2), and lymphomas (WSR 15·2). In children aged 15–19 years (based on 100 860 cases), the ASR was 185·3 per million person-years, the most common being lymphomas (ASR 41·8) and the group of epithelial tumours and melanoma (ASR 39·5). Incidence varied considerably between and within the described regions, and by cancer type, sex, age, and racial and ethnic group. Since the 1980s, the global WSR of registered cancers in children aged 0–14 years has increased from 124·0 (95% CI 123·3–124·7) to 140·6 (140·1–141·1) per million person-years.InterpretationThis unique global source of childhood cancer incidence will be used for aetiological research and to inform public health policy, potentially contributing towards attaining several targets of the Sustainable Development Goals. The observed geographical, racial and ethnic, age, sex, and temporal variations require constant monitoring and research.FundingInternational Agency for Research on Cancer and the Union for International Cancer Control.

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“…En Colombia se diagnostican cerca de 500 casos nuevos de LLA en menores de 18 años cada año, con una incidencia aproximada de 2 a 5 casos por 100.000 por año, en menores de 15 años (12)(13)(14), con un pico de incidencia entre los 2 a 5 años. La supervivencia global y libre de la enfermedad es menor de 50 % por múltiples razones: altas tasas de abandono, toxicidad del tratamiento, falta de intensidad de quimioterapia y falla de tratamiento (2,7,(14)(15)(16)(17).…”

Section: Introductionunclassified

Resultados del Protocolo ACHOP 2006 en los niños con leucemia linfoblástica aguda en la Fundación HOMI Hospital de la Misericordia de Bogotá, en el periodo 2007 - 2012

Sarmiento-Urbina

Ballesteros

Contreras-Acosta³

et al. 2019

Iatreia

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Introducción: la leucemia aguda es la neoplasia más común en niños, constituye aproximadamente el 25 % de todos los tumores en la infancia. En Colombia la proporción de curación, alrededor del 50 %, es inferior a lo informado en países desarrollados.Objetivo: el objetivo principal es determinar la supervivencia global y libre de eventos, la proporción de abandono y recaída de los niños con el diagnóstico de leucemia linfoide aguda tratados con el Protocolo ACHOP 2006.Materiales y métodos: estudio descriptivo de tipo cohorte de 183 pacientes menores de 18 años, con el diagnóstico confirmado de leucemia linfoide aguda, que recibieron tratamiento en la Fundación HOMI desde el 2007 hasta el 2012. Los análisis de supervivencia se obtuvieron con curvas de Kaplan-Meier.Resultados: se analizó la supervivencia global a 2, 3 y 5 años con resultados de 89 %, 87,3 % y 74,7 % (IC 95 % 67-80,9), respectivamente. A los 5 años la supervivencia para el grupo de riesgo estándar fue de 78,6 % (IC 95 % 68,3 - 85,1) y para el de riesgo alto 61,9 % (IC 95 % 50,7-73). La supervivencia libre de evento, al considerar el abandono y traslado a otra institución como evento, fue de 56,3 % (IC 95 % 45,5-65,8) a los 5 años. La mortalidad en inducción fue de 3,8 %, la mortalidad relacionada con el tratamiento fue 3,4 %. Treinta y dos pacientes (17 %) recayeron, el abandono fue de 16,4 % y los traslados de 10,4 %. La principal complicación del tratamiento fueron las infecciones.

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Caregivers' Self-Reported Absence of Social Support Networks is Related to Treatment Abandonment in Children With Cancer

Cited by 16 publications

References 34 publications

Holistic support coupled with prospective tracking reduces abandonment in childhood cancers: A report from India

Holistic support coupled with prospective tracking reduces abandonment in childhood cancers: A report from India

International incidence of childhood cancer, 2001–10: a population-based registry study

Resultados del Protocolo ACHOP 2006 en los niños con leucemia linfoblástica aguda en la Fundación HOMI Hospital de la Misericordia de Bogotá, en el periodo 2007 - 2012

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