Care solution effects on contact lens in vivo wettability

Fagehi, Raied; Pearce, Elizabeth; Oliver, Katherine M.; Abusharha, Ali; Tomlinson, Alan

doi:10.1111/cxo.12518

Cited by 9 publications

(9 citation statements)

References 47 publications

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“…of the CL performance [1,14,28]. The data on the impact of internal wetting agents on the contact angles of worn SiHy CLs are also inconclusive [7,8] and although it was found that the presence of PVP (wetting agent) does not significantly improve the clinical performance of SiHy [31], the small sample size (40 patients per CL sample) limited the statistical power of the study.…”

Section: Discussionmentioning

confidence: 99%

“…Great efforts have been devoted to the design of daily disposable SiHy CLs that can maintain high wettability even after extended wear. Different approaches have been implemented [7,8]: (i) from incorporation of wetting agents (polyvinylpyrrolidone, poloxamers, etc.) in the CL core and in CL solutions to (ii) the design of sophisticated CL surfaces with high water holding properties.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Air Exposure Time on the Water Contact Angles of Daily Disposable Silicone Hydrogels

Eftimov

Yokoi

Peev

et al. 2019

IJMS

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The wettability of silicone hydrogel (SiHy) contact lens (CLs) is crucial for the pre-lens tear film stability throughout the day. Therefore, sessile drop and captive bubble setups were used to study the advancing and receding water contact angles (CA) of four SiHy materials: narafilcon A (TE), senofilcon A (AOD), stenfilcon A (MD), and delefilcon A (DT). TE and AOD have 48% and 38% water content, respectively, and no surface coating. MD (54% water) implements “smart chemistry” with just 4.4% bulk silicone content, while DT has >80% water at its surface. These SiHy were subjected to continuous blink-like air exposure (10 s)/rehydration (1s) cycles for 0, 1, 2, 3, 4, 6, 8, 10, 12, 14, and 16 h. The advancing CA, which measures the rehydration propensity of the CL surface, proved to be the most sensitive parameter to discriminate between the samples. The order of performance for the entire time scale was DT > MD >> AOD ≥ TE. The extended desiccation/rehydration cycling increased the differences between the CA of DT and MD compared to AOD and TE. This suggests that the low Si surface content and the high surface hydration are major determinants of SiHy wettability.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of Air Exposure Time on the Water Contact Angles of Daily Disposable Silicone Hydrogels

Eftimov

Yokoi

Peev

et al. 2019

IJMS

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“…Indirectly, contact lens wettability can be evaluated by assessing features of the PLTF that provide useful information about the level of tears spreading on the lens. Tear coverage can be assessed by examining any PLTF deficiency on the contact lens surface through slit lamp observation by examining the quality of a specular reflection at high magnification, using interferometry observation techniques and with the use of grading scales [92,[95][96][97][98][99][100][101][102][103]. Another possibility is to evaluate the optical quality of the contact lens on the eye in terms of higher-order aberrations, since the surface wetting of a contact lens influences optical quality [104].…”

Section: Measuring Wettability In Vivomentioning

confidence: 99%

“…its location being predominantly on the surface or in the bulk of the lens) were partially dependant on whether a surface coating on the lens was present [253]. While several studies report differences in lens wettability or adsorption of wetting agents with different lens care solutions in vitro [254,255], reports are inconsistent on the ability of lens care solutions to maintain contact lens wettability during wear [103,106,110,[256][257][258].…”

Section: Lens Care Solutionsmentioning

confidence: 99%

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Willcox

Keir

Maseedupally

et al. 2021

Contact Lens and Anterior Eye

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Contact lens materials have undergone significant changes over the past 20 years, particularly with respect to the introduction of silicone hydrogel materials. Whilst this development addressed hypoxic issues, other important areas relating to contact lens success, notably comfort, require further research.Contact lens wettability remains a crucially important part of biocompatibility. Contact lenses can be made more wettable by incorporation of surfactants into blister packs, internal wetting agents, surface treatments or care solutions. However, there remains no clear association between contact lens wettability and comfort, making it challenging to determine the potential for these approaches to be of significant clinical benefit. Most contact lenses are used on a daily wear, reusable basis, which requires them to be disinfected when not worn. The ideal disinfecting solution would also improve comfort during wear. However, balancing these requirements with other factors, including biocompatibility, remains a challenge. Soft lens materials invariably take up and subsequently release certain components of disinfecting solutions onto the ocular surface. This may affect tear film stability and the normal ocular microbiome, and further research is needed in this area to determine whether this has any affect on comfort. Finally, contact lens materials sorb components of the tear film, and these interactions are complex and may change the biochemistry of the tear film, which in turn may affect their comfort.In conclusion, the interaction between lens materials, tear film and disinfection solution plays an important role in the biocompatibility of lenses. However, the exact role and whether this can be altered to improve biocompatibility and comfort during wear remains debatable. This report summarises the best available evidence to examine this complex relationship and the opportunities for practitioners to enhance in-eye comfort of contemporary lenses, along with providing suggestions for areas of study that may provide further information on this topic.

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“…Tear film dysfunction causes pain and enhanced immune activity, which may interfere with vision [18]. Some studies have shown that the coefficient of friction (COF) of silicone hydrogels may be changed due to long-term reaction with the tear film components, indicating that long-lasting moist lens is favourable for maintaining a low COF in a long time [19], and some research studies related to the design of novel highly weTable contact lens materials have been done already [20][21][22]. Blinking and eye rotation are the most important physiological processes for lens and lens friction, which can lead to various corneal infections, corneal ulcers, decreased vision, and other symptoms [23].…”

Section: Introductionmentioning

confidence: 99%

Tribological behaviour of two kinds of typical hydrogel contact lenses in different lubricants

Qin

Zhu

Zhou

et al. 2019

Biosurface and Biotribology

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Contact lenses have a special effect on the treatment of some eye diseases. The tribological behaviour of soft contact lenses considerably influences their clinical performance. Improper wearing of contact lenses can lead to mechanical damage of the contact interface, which can lead to pathological changes in the eyeball. In this study, the sliding friction of two kinds of typical contact lens materials (hilaficon-B and lotrafilcon-B) in three lubricants (distilled water, care solution, and eye drop) and tribological parameters are studied, using PMMA as a control. Hydrogels have high water content but the dehydration rate is high. Silicone hydrogels have low initial water content but low dehydration rates. The friction test in distilled water gives the highest coefficient of friction value. The care solution and eye drop significantly reduce the friction coefficient of the lens due to the formation of tribofilm.

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Care solution effects on contact lens in vivo wettability

Cited by 9 publications

References 47 publications

Impact of Air Exposure Time on the Water Contact Angles of Daily Disposable Silicone Hydrogels

Impact of Air Exposure Time on the Water Contact Angles of Daily Disposable Silicone Hydrogels

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Tribological behaviour of two kinds of typical hydrogel contact lenses in different lubricants

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