Care, Feeding and Fate of Premature and Full Term Infants Born of Tuberculous Mothers

Ratner, Bret

doi:10.1001/archpedi.1951.02040030482002

Cited by 16 publications

(6 citation statements)

References 16 publications

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“…evidence documenting that TB has adverse effects on pregnancy outcomes, but also extends the literature to include the experiences of an Asian population. Although prior studies also observed a significant relationship between TB in mothers and preterm births, [7][8][9] we failed to find a significant relationship. Moreover, some studies did not find any adverse effects derived from TB in neonates.…”

Section: Discussioncontrasting

confidence: 99%

Increased risk of low birthweight and small for gestational age infants among women with tuberculosis

Lin

Chen

2010

BJOG

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Objective As the relationship between tuberculosis (TB) and fetal outcomes remains unclear, this study used a 3-year nationwide population-based data set to determine the risk of adverse pregnancy outcomes [low birthweight (LBW), preterm birth and small for gestational age (SGA) infants] among women with TB.Design A cross-sectional retrospective study.Setting Taiwan.Sample Linking the Taiwan birth certificate registry and the Taiwan National Health Insurance Research Dataset, we identified 761 women who gave birth from 2001 to 2003 and who had received medication treatment for TB during their pregnancy, together with 3805 unaffected women matched in terms of age and year of delivery.Methods Conditional logistic regression analyses were performed to compare the risk of LBW, preterm birth and SGA for mothers with TB and unaffected mothers.Main outcome measures The risk of LBW, preterm birth and SGA.Results Mothers diagnosed with TB had significantly higher percentages of LBW (8.5 versus 6.4%, P = 0.033) and SGA (19.7 versus 16.7%, P = 0.048) infants than unaffected mothers. However, there was no significant difference in preterm birth (8.0 versus 8.0%, P = 0.961) between these two groups. The adjusted odds ratios of having LBW and SGA infants for mothers with TB were 1.35 (95% CI = 1.01-1.81) and 1.22 (95% CI = 1.00-1.49), respectively, compared with unaffected mothers.Conclusions We concluded that women diagnosed with TB during pregnancy are at increased risk for having LBW and SGA babies, compared with unaffected mothers. We suggest that clinicians should make women with TB aware of the potential risks before planning a child.

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Section: Discussioncontrasting

confidence: 99%

Increased risk of low birthweight and small for gestational age infants among women with tuberculosis

Lin

Chen

2010

BJOG

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“…Unfortunately, combined influences of maternal TB and co‐existing undernutrition are not explored systematically in clinical studies. The potential role of socioeconomic factors 55 and maternal impoverished nutrition 56 has been suggested in earlier studies from developed countries. A recent study from India also showed that multiparity, anemia, undernutrition and overcrowding, all added to the problem of maternal TB 10 .…”

Section: Resultsmentioning

confidence: 96%

Tuberculosis in pregnancy: The challenges for South Asian countries

Jana

Barik²,

Arora

et al. 2012

J of Obstet and Gynaecol

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Abstractj og_1856 1125..1136Aim: Despite tuberculosis (TB) being a global problem, maternal TB remains an unrecognized and underestimated tragedy, especially in South Asian countries. Therefore, we performed a non-systematic review regarding implications of maternal TB on obstetric and perinatal outcomes in the South Asian context. Material and Methods:We reviewed original studies, both descriptive and analytical, that originated from South Asian countries following an electronic search supplemented by a manual search. Although relevant studies from developed countries were reviewed, they were not included in the tabulation process because those studies had different socioeconomic/epidemiological background. Results: Diagnosis of TB is often delayed during pregnancy, because of its non-specific symptoms, and overlapping presentation with other infectious diseases. Poverty, undernutrition, lack of social support and poor health infrastructure along with complications of TB and need for prolonged medications lead to increased maternal morbidity and mortality. Maternal TB in general (except lymphadenitis), is associated with an increased risk of small-for-gestational age, preterm and low-birthweight neonates, and high perinatal mortality. These adverse perinatal outcomes are even more pronounced in women with advanced disease, late diagnosis, and incomplete or irregular drug treatment. There could be a synergy of TB, socioeconomic and nutritional factors, which might have contributed to adverse perinatal effects, especially in low-income countries. Conclusions: As active TB poses grave maternal and perinatal risks, early, appropriate and adequate anti-TB treatment is a mainstay for successful pregnancy outcome. The current knowledge gaps in perinatal implications of maternal TB can be addressed by a multicenter comparative cohort study.

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“…Congenital tuberculosis is uncommonly found in the infants of women known themselves to have pulmonary or placental tuberculosis.2 3 In 1935 Beitzke laid down diagnostic criteria: M. tuberculosis should be grown from the infants tissues.4 In addition, a primary complex should be shown in the liver indicating carriage of bacilli through the umbilical vein, or tuberculous lesions be discovered within a few days of life where the possibility of extrauterine infection could be excluded. The advent of specific chemotherapy has reduced the prevalence of tuberculosis and made histological confirmation in the newborn rarely necessary so that these precise criteria can only infrequently be met.…”

Section: Discussionmentioning

confidence: 99%