Care and Management of the Infant of the HIV-1-Infected Mother

Paintsil, Elijah; Andiman, Warren A.

doi:10.1053/j.semperi.2007.02.007

Cited by 12 publications

(10 citation statements)

References 75 publications

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“…Perinatal transmission rates as low as 1% has been achieved as a result of the use of the PACTG 076 regimen (Table 2)(7), HAART regimens, and appropriate management of labor and delivery. Therefore, the birth of an infected child in a resource-rich country is now a sentinel health event signaling a chain of missed opportunities and barriers to available PMTCT programs (8).…”

Section: Pmtct Successes In Resource-rich Countriesmentioning

confidence: 99%

Update on successes and challenges regarding mother-to-child transmission of HIV

Paintsil

Andiman²

2009

Current Opinion in Pediatrics

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Purpose of review-There is an unprecedented global commitment to reverse the pediatric HIV epidemic by making prevention of mother-to-child transmission (MTCT) services accessible in all countries. This review outlines the successes made and the challenges that remain.Recent Findings-In resource-rich countries, MTCT rates of HIV as low as 1% has been achieved. The efficacy of short course antiretrovirals (ARVs) for the prevention of MTCT (PMTCT) in Africa is estimated at 50%. Co-infections with herpes simplex virus type 2 (HSV-2), other sexually transmitted infections resulting in genital ulcers, and endemic infectious diseases (e.g., malaria) may increase the risk of MTCT of HIV. Vertical transmission of drug-resistant viruses has been reported; the prevalence and effect of transmitted resistant virus on treatment outcomes are under investigation. Obstacles facing PMTCT in resources-limited countries include lack of health care infrastructure, limited manpower, and competing public health priorities with the limited health care budget.Summary-While the birth of an HIV-infected child in a resource-rich country is now a sentinel health event, in most resource-limited countries the birth of an HIV-infected child continues to be the status quo. Comprehensive PMTCT including ARV treatment for HIV-infected women and HIVinfected children should be paramount in resource-limited countries.

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Section: Pmtct Successes In Resource-rich Countriesmentioning

confidence: 99%

Update on successes and challenges regarding mother-to-child transmission of HIV

Paintsil

Andiman²

2009

Current Opinion in Pediatrics

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“…PMTCT rates as low as 1% has been achieved as a result of the use of the PACTG 076 regimen [21], cART, and appropriate management of labor and delivery. The birth of an infected child in a HIC is now rare and represents systems failure and missed opportunities during pregnancy, labor, and delivery [22]. The WHO recommends Option B+ as the main strategy to eliminate MTCT: Option B+ proposes that all HIV-infected women receive lifelong ART beginning at their first pregnancy, regardless of CD4 count [2].…”

Section: Hivmentioning

confidence: 99%

Infectious Diseases of Poverty in Children

Hansen

Paintsil

2016

Pediatric Clinics of North America

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“…Along with prognosis, the results of measures to reduce motherto-child HIV transmission have greatly improved in the era of highly active antiretroviral therapy (HAART), and women infected with HIV can consider pregnancy more optimistically than in the past [1][2][3]. When antiretroviral monotherapy was introduced, systematic cesarean delivery helped reduce mother-to-child transmission [4,5].…”

Section: Introductionmentioning

confidence: 99%