Cardiovascular ultrasound exploration contributes to predict incident atrial fibrillation in arterial hypertension: The Campania Salute Network

Losi, Maria Angela; Izzo, Raffaele; Marco, Marina De; Canciello, Grazia; Rapacciuolo, Antonio; Trimarco, Valentina; Stabile, Eugenio; Rozza, Francesco; Esposito, Giovanni; Luca, Nicola De; Simone, Giovanni de; Trimarcö, Bruno

doi:10.1016/j.ijcard.2015.07.019

Cited by 43 publications

(20 citation statements)

References 36 publications

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“…In our study, E/A ratios were lower in the increased LVEDP group, and there was no difference in terms of E′ velocity or E/E′ ratio between the groups. In hypertensive patients, the left atrium dimensions are usually increased because of the increase of the left ventricular filling pressures, which are associated with adverse cardiovascular events, atrial fibrillation, and diastolic dysfunction . In line with these previous findings, we noted a positive correlation between the LVEDP and the left atrial volume index.…”

Section: Discussionsupporting

confidence: 91%

Association of P wave peak time with left ventricular end‐diastolic pressure in patients with hypertension

Burak

Çağdaş

Rencüzoğulları

et al. 2019

J of Clinical Hypertension

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Left ventricular diastolic dysfunction (LVDD) is commonly seen in hypertensive patients, and it is associated with increased morbidity and mortality. Hence, the detection of LVDD with a simple, inexpensive, and easy‐to‐obtain method can contribute to improving patient prognosis. Therefore, we aimed to evaluate whether there was any association between the electrocardiographic P wave peak time (PWPT) and invasively measured left ventricular end‐diastolic pressure (LVEDP) in hypertensive patients who had undergone coronary angiography following preliminary diagnosis of coronary artery disease. A total of 78 patients were included in this cross‐sectional study. The PWPT was defined as the time from the beginning of the P wave to its peak, and it was calculated from the leads DII and VI. In all patients, LVEDP was measured in steady state. The PWPT in lead DII was significantly longer in patients with high LVEDP; however, there was no significant difference between groups in terms of PWPT in the lead VI. In multivariable analysis, PWPT in lead DII was found to be independent predictor of increased LVEDP (OR: 1.257, 95% CI: 1.094‐1.445; P = 0.001). In receiver operating characteristic curve analysis, the optimal cut‐off value of PWPT in the lead DII for prediction of elevated LVEDP was 64.8 ms, with a sensitivity of 68.7% and a specificity of 91.3% (area under curve: 0.882, 95% CI: 0.789‐0.944, P < 0.001). In conclusion, this study result suggested that prolonged PWPT in the lead DII may be an independent predictor of increased LVEDP among hypertensive patients.

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Section: Discussionsupporting

confidence: 91%

Association of P wave peak time with left ventricular end‐diastolic pressure in patients with hypertension

Burak

Çağdaş

Rencüzoğulları

et al. 2019

J of Clinical Hypertension

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“…Abnormal left ventricular geometry in hypertensive patients is frequently associated with diastolic dysfunction [127,135], which can be further evaluated by a combination of transmitral flow and tissue Doppler studies [136]. Left atrial size is also frequently increased in hypertensive patients and is associated with adverse cardiovascular events [128,137] and incident AF [138], and is related to diastolic dysfunction [139,140]. During the diagnostic workup for secondary hypertension, a suprasternal view should also be performed for the identification of aortic coarctation [141].…”

Section: Transthoracic Echocardiography In Hypertensionmentioning

confidence: 99%

2018 ESC/ESH Guidelines for the management of arterial hypertension

Williams¹,

Mancia²,

Spiering³

et al. 2018

Journal of Hypertension

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“…Quality‐controlled validation was performed for echocardiographic exams performed at the enrollment in the registry (baseline), at the last available echocardiogram before a censored event, or at the time of the last available visit before the present database generation. As previously reported, echocardiograms were recorded on videotapes, stored digitally, and read offline by 1 expert reader under the supervision of a senior faculty member on dedicated workstations (MediMatic, Genova, Italy). Measurements were made according to the joint American Society of Echocardiography/European Association of Echocardiography recommendations .…”

Section: Methodsmentioning

confidence: 99%

Left Ventricular Hypertrophy Regression During Antihypertensive Treatment in an Outpatient Clinic (the Campania Salute Network)

Lønnebakken

Izzo

Mancusi

et al. 2017

JAHA

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100

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BackgroundRegression of left ventricular (LV) hypertrophy (LVH) has been a goal in clinical trials. This study tests the external validity of results of clinical trials on LVH regression using a large registry from a tertiary care center, to identify phenotypes less likely to achieve regression of LVH.Methods and ResultsPatients from the Campania Salute Network, free of prevalent cardiovascular disease, but with echocardiographic LVH (defined as LV mass index [LVMi] >47 g/m2.7 in women and >50 g/m2.7 in men) were included. During a median follow‐up of 67 months, clear‐cut regression of LVH was documented in 14% of patients (13±8% reduction of initial LVMi) or 23% when also considering those with a reduction of LVMi ≥5 g/m2.7. Patients with persistent LVH were older with longer duration of hypertension, suboptimal blood pressure (BP) control, larger body mass index, LV mass, and carotid intima‐media thickness and included more women and subjects with diabetes mellitus, isolated systolic hypertension, and metabolic syndrome (all P<0.05). Number and class of antihypertensive drugs during follow‐up did not differ between groups. In multiple logistic regression analysis, older age, female sex, obesity, higher baseline LVMi and carotid intima‐media thickness, and suboptimal BP control were significant covariates of persistent LVH (all P≤0.01), independent of diabetes, duration of hypertension, isolated systolic hypertension, follow‐up time and number and class of antihypertensive drugs.ConclusionsEarly initiation of antihypertensive treatment, aggressive BP control, and attention to metabolic aspects are critical to avoid irreversible LVH.

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Cardiovascular ultrasound exploration contributes to predict incident atrial fibrillation in arterial hypertension: The Campania Salute Network

Cited by 43 publications

References 36 publications

Association of P wave peak time with left ventricular end‐diastolic pressure in patients with hypertension

Association of P wave peak time with left ventricular end‐diastolic pressure in patients with hypertension

2018 ESC/ESH Guidelines for the management of arterial hypertension

Left Ventricular Hypertrophy Regression During Antihypertensive Treatment in an Outpatient Clinic (the Campania Salute Network)

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