Cardiovascular System Abnormalities in Sickle Cell Anaemia: Clinical Findings in Steady State Adult Nigerian Patients

Oguanobi, NI; Onwubere, Bjc; Ejim, EC; Anisiuba, BC; Og, Ibegbulam; Ukekwe, FI

doi:10.4172/2155-9880.1000423

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…The RPP and DBP are higher in both SCA and control female though not significant when compared with their male counterparts. The reason for increased SBP in males has been attributed to androgen which was supported by the report of Reckelhoff et al 30 that androgen receptor blockage reduces the blood pressure in males and administration of testosterone to ovariectomized females increases the blood pressure and modifies the pressure natriuresis. The significant difference in HR was largely accounted for by the size of the heart which is smaller in females than males.…”

Section: Discussionmentioning

confidence: 84%

“…18 This may explain the end-organ manifestations like ischaemia and infarction that occurs in some organs like brain due to the inability to perfuse the cerebral tissues because of persistently reduction in MAP. 19 Few studies assessing the arterial blood pressure indices and the implications had been conducted in this environment despite the highest population of individuals with SCA, hence this study. The aim of the present study is to assess the arterial blood pressure indices and the clinical implications in individuals with SCA compared with normal Hb AA among young adult individuals in Nigeria.…”

Section: Introductionmentioning

confidence: 99%

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Untitled

2023

JCCR

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Background: Sickle cell disease (SCD) is a hereditary chronic haemolytic disorder characterised by repeated vaso-occlusion and chronic haemolysis resulting into chronic complications such as pulmonary arterial hypertension (PAH) and early mortality.Aim: This study is aimed at assessing the arterial blood pressure indices and the clinical implications in individuals with SCA compared with normal Haemoglobin AA among young adult individuals in Nigeria. Subjects and Methods:A total of 132 young adults (18 -35 years) participated in the study. They were classified into two groups; 69 cases (participants with Hb SS) and 63 age and sex matched controls (participants with Hb AA) which were purposively selected after haemoglobin typing using electrophoresis method. Blood pressure (BP) measurement was done three times after five minute rest using a validated digital sphygmomanometer (Lumiscope) of appropriate cuff size attached to the arm. The average of the last two measurements was calculated and used as the systolic and diastolic blood pressure. Pulse Pressure (PP), Mean Arterial Pressure (MAP), Rate Pressure Product (RPP) was calculated using standard formulae. Data were analyzed using descriptive and inferential statistics and alpha value was set as < 0.05.

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Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Untitled

2023

JCCR

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“…SCA causes abnormalities in the function of the heart and other organs. Cardiac features, such as fatigue, dyspnea on exertion, palpitations, mild lower extremity swelling, chest pain, tachycardia, wide pulse pressure, presence of distended neck veins, displaced apex beat, and presence of murmurs, initially occur from anemia [4][5]. Dyspnea at rest, orthopnea, and extensive lower limb swelling may be associated with severe anemia [6].…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Disease Severity and Resting Electrocardiograms of Adults With Sickle Cell Anemia in a Tertiary Institution in Southern Nigeria

Dic-Ijiewere¹,

Emorinken²,

Obasohan³

et al. 2021

Cureus

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Evaluation of Tp-e Interval and Tp-e/QTc Ratio among Patients with Steady State Sickle Cell Disease

Akinlade¹,

Akintunde²,

Olabode³

et al. 2019

WJCD

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Sickle cell disease (SCD) has been regarded as an inflammatory and procoagulatory disease with profound cardiovascular abnormalities including propensity for ventricular arrhythmogenesis. Tp-e and Tpe/QTc ratio however has been proposed as better indicators of arrythmogenesis and has been shown to be prolonged in many inflammatory conditions and correlate with levels of inflammatory markers. However, correlation between Tpe/QTc ratio and the level of highly sensitive C-reactive protein (hs-CRP) and plasminogen activator inhibitor (PAI) have not been reported in SCD. This study aims at evaluating Tp-e Interval and Tp-e/QTc ratio among steady state Sickle cell disease patients in relationship to the degree of anaemia, inflammatory and profibrotic markers. Methodology: A cross-sectional hospital-based study comprises 30 sickle cell anaemia patients in steady state with an equal number of controls having genotype HbAA and HbAS respectively. Clinical, laboratory and ECG parameters were obtained. Results: A total of 90 participants are with mean age 24.2 ± 5.6. The study showed that sickle cell disease patient had significantly lower level of PCV and higher level of PAI, platelet and total white cell count (p value < 0.05). C-reactive protein was also higher in them. 76.7% of HbSS patients had abnormal ECG. QTc and Tp-e were also prolonged in sickle cell disease patients compared with controls. An association was found between the level of PCV, PAI and prolonged Tp-e and QTc. Conclusion: Sickle cell disease patients have higher levels of inflammatory markers and abnormal ECG patterns are common in them. Moreover, the levels of these inflammatory markers correlate with Tp-e parameters.

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Cardiovascular System Abnormalities in Sickle Cell Anaemia: Clinical Findings in Steady State Adult Nigerian Patients

Cited by 3 publications

References 9 publications

Untitled

Untitled

Relationship Between Disease Severity and Resting Electrocardiograms of Adults With Sickle Cell Anemia in a Tertiary Institution in Southern Nigeria

Evaluation of Tp-e Interval and Tp-e/QTc Ratio among Patients with Steady State Sickle Cell Disease

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