Cardiovascular risk profile of patients with spondylarthropathies, particularly ankylosing spondylitis and psoriatic arthritis

Peters, Mike J L; Horst‐Bruinsma, Irene E. van der; Dijkmans, Ben A. C.; Nurmohamed, Michael T.

doi:10.1016/j.semarthrit.2004.07.010

Cited by 342 publications

(219 citation statements)

References 63 publications

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“…114 Recent evidence suggests that patients with PsA are at an increased risk for developing cardiovascular disease. [117][118][119] A study from the integrated outcomes database identified 3066 patients with PsA which were matched 1:4 with individuals in the database on the basis of age, sex, location and length in the plan. The prevalence ratio of peripheral vascular disease (1.6), congestive heart failure (1.5), atherosclerosis (1.4), ischemic heart disease (1.3), cerebrovascular disease (1.3), and hypertension (1.3) were higher in patients than controls.…”

Section: Psoriatic Arthritismentioning

confidence: 99%

National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening

Kimball

Gladman

Gelfand

et al. 2008

Journal of the American Academy of Dermatology

377

321

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Section: Psoriatic Arthritismentioning

confidence: 99%

National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening

Kimball

Gladman

Gelfand

et al. 2008

Journal of the American Academy of Dermatology

377

321

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“…increased cardiovascular (CV) risk (2)(3)(4). Although specific CV disorders (valvular disease and conduction disturbances) occur more frequently in AS (4,5), accelerated atherosclerotic disease probably contributes to the increased CV risk as well (6,7).…”

mentioning

confidence: 99%

“…Although specific CV disorders (valvular disease and conduction disturbances) occur more frequently in AS (4,5), accelerated atherosclerotic disease probably contributes to the increased CV risk as well (6,7). Atherosclerosis is a multifactorial process, but its most well-established risk factor is dyslipidemia.…”

mentioning

confidence: 99%

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Improvement of lipid profile is accompanied by atheroprotective alterations in high‐density lipoprotein composition upon tumor necrosis factor blockade: A prospective cohort study in ankylosing spondylitis

Eijk¹,

Vries²,

Levels³

et al. 2009

Arthritis & Rheumatism

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Objective. Cardiovascular mortality is increased in ankylosing spondylitis (AS), and inflammation plays an important role. Inflammation deteriorates the lipid profile and alters high-density lipoprotein cholesterol (HDL-c) composition, reflected by increased concentrations of serum amyloid A (SAA) within the particle. Anti-tumor necrosis factor (anti-TNF) treatment may improve these parameters. We therefore undertook the present study to investigate the effects of etanercept on lipid profile and HDL composition in AS.Methods. In 92 AS patients, lipid levels and their association with the inflammation markers C-reactive protein (CRP), erythrocyte sedimentation rate, and SAA were evaluated serially during 3 months of etanercept treatment. HDL composition and its relationship to inflammation markers was determined in a subgroup of patients, using surface-enhanced laser desorption/ ionization time-of-flight analysis.Results. With anti-TNF treatment, levels of all parameters of inflammation decreased significantly, whereas total cholesterol, HDL-c, and apolipoprotein A-I (Apo A-I) levels increased significantly. This resulted in a better total cholesterol:HDL-c ratio (from 3.9 to 3.7) (although the difference was not statistically significant), and an improved Apo B:Apo A-I ratio, which decreased by 7.5% over time (P ‫؍‬ 0.008). In general, increases in levels of all lipid parameters were associated with reductions in inflammatory activity. In addition, SAA was present at high levels within HDL particles from AS patients with increased CRP levels and disappeared during treatment, in parallel with declining plasma levels of SAA.Conclusion. Our results show for the first time that during anti-TNF therapy for AS, along with favorable changes in the lipid profile, HDL composition is actually altered whereby SAA disappears from the HDL particle, increasing its atheroprotective ability. These findings demonstrate the importance of understanding the role of functional characteristics of HDL-c in cardiovascular diseases related to chronic inflammatory conditions.

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“…4,15 These include diffuse increase in myocardial interstitial connective tissue, myocarditis, amyloidosis, aortic insufficieny, conduction disturbances, cardiomyopathy, pericarditis and mitral valve diseases. [15][16][17] TDI allows quantitative measurements of myocardial contraction and relaxation velocities of a selected myocardial segment. TDI allows providing velocities of normal and pathologic myocardial structures during the cardiac cycle.…”

Section: Discussionmentioning

confidence: 99%

Assessment of left ventricular function by tissue Doppler imaging in patients with ankylosing spondylitis

Kuloğlu¹,

Bayram²,

Erten³

et al. 2012

Rheumatol Rep

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Ankylosing spondylitis (ASp) is a chronic, inflammatory and systemic disease affecting pericardium, myocardium and the conduction system of the heart. In this study, we aimed to analyse left ventricular systolic and diastolic functions using tissue Doppler imaging (TDI). 30 patients with ASp and 30 healthy volunteers having the similar demographic characteristics were included. Left ventricular systolic and diastolic functions were assessed by using two dimensional (2D) echocardiography, M-mode, pulsed-wave (PW) and tissue Doppler echocardiography. The peak systolic velocity (Sm), early diastolic myocardial peak velocity (m), late diastolic myocardial peak velocity (Am), isovolumic acceleration (IVA), myocardial precontraction time (PCTm), myocardial contraction time (CTm), myocardial relaxation time (RTm), and myocardial performance index (MPI) were measured at septal and lateral mitral annulus. In conventional echocardiography, end-diastolic interventricular septum and posterior wall diameters were higher in patients with ASp than the control group. The ratio of E/A was significantly lower and deceleration time was significantly prolonged in patients with ASp, but mitral E and A velocities, isovolumic relaxation time and MPI were similar in patient and control group (P>0.05). Left ventricular lateral and septal wall tissue Doppler echocardiography showed that Em, Em/Am ratio and CTm were significantly lower, IVRTm was longer and MPI was higher in patients with ASp. No significant differences were detected between the groups for IVA, Sm, Am, PCTm, PCTm/CTm ratio (P>0.05). We have demonstrated that in patients with ASp, diastolic functions were impaired but systolic functions were preserved by using TDI.

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Cardiovascular risk profile of patients with spondylarthropathies, particularly ankylosing spondylitis and psoriatic arthritis

Cited by 342 publications

References 63 publications

National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening

National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening

Improvement of lipid profile is accompanied by atheroprotective alterations in high‐density lipoprotein composition upon tumor necrosis factor blockade: A prospective cohort study in ankylosing spondylitis

Assessment of left ventricular function by tissue Doppler imaging in patients with ankylosing spondylitis

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