Cardiovascular risk in patients with bipolar disorder

García-Portilla, María Paz; Sáiz, Pilar A.; Bascarán, María Teresa Bobes; Martíneza, Sara; Benabarre, Antonio; Sierra, Pilar; Torres, Pedro Iturralde; Montes, José Manuel García; Bousoño, Manuel; Bobes, Julio

doi:10.1016/j.jad.2008.09.008

Cited by 67 publications

(47 citation statements)

References 27 publications

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“…8 Furthermore, studies investigating the prevalence of the metabolic syndrome in BD patients have reported varying rates as low as 18-25.3% in Belgium 36 and Italy, 37 33.9% in Taiwan, 38 and as high as 40-49% in the United States. 39,40 A recent report on cardiovascular risk factors in BD patients 41 has also pointed out differences between prevalence rates not only among different countries, but also according to the cardiovascular risk estimation method used. In addition to these findings, our results underscore the relevance of considering regional differences when studying cardiovascular risk factors in psychiatric patients.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular risk factors in outpatients with bipolar disorder: a report from the Brazilian Research Network in Bipolar Disorder

Gomes

Almeida

Magalhães

et al. 2013

Rev. Bras. Psiquiatr.

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Objective: Bipolar disorder (BD) is associated with significant morbidity and mortality due to comorbid general medical conditions, particularly cardiovascular disease. This study is the first report of the Brazilian Research Network in Bipolar Disorder (BRN-BD) that aims to evaluate the prevalence and clinical correlates of cardiovascular risk factors among Brazilian patients with BD. Methods: A cross-sectional study of 159 patients with DSM-IV BD, 18 years or older, consecutively recruited from the Bipolar Research Program (PROMAN) in Sã o Paulo and the Bipolar Disorder Program (PROTAHBI) in Porto Alegre. Clinical, demographic, anthropometric, and metabolic variables were systematically assessed. Results: High rates of smoking (27%), physical inactivity (64.9%), alcohol use disorders (20.8%), elevated fasting glucose (26.4%), diabetes (13.2%), hypertension (38.4%), hypertriglyceridemia (25.8%), low HDL-cholesterol (27.7%), general (38.4%) and abdominal obesity (59.1%) were found in the sample. Male patients were more likely to have alcohol use disorders, diabetes, and hypertriglyceridemia, whereas female patients showed higher prevalence of abdominal obesity. Variables such as medication use pattern, alcohol use disorder, and physical activity were associated with selected cardiovascular risk factors in the multivariable analysis. Conclusion: This report of the BRN-BD provides new data regarding prevalence rates and associated cardiovascular risk factors in Brazilian outpatients with BD. There is a need for increasing both awareness and recognition about metabolic and cardiovascular diseases in this patient population.

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Section: Discussionmentioning

confidence: 99%

Cardiovascular risk factors in outpatients with bipolar disorder: a report from the Brazilian Research Network in Bipolar Disorder

Gomes

Almeida

Magalhães

et al. 2013

Rev. Bras. Psiquiatr.

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“…Estimates indicate approximately a 2-to 3-fold increased risk of cardiovascular disease across a range of psychiatric disorders. [5][6][7][8][9][10][11][12][13][14] The reduction in life expectancy associated with this increased risk is estimated to be greater than loss of years associated with heavy smoking alone. 15 Autonomic regulation of the heart plays a key role in cardiovascular functioning.…”

Section: Introductionmentioning

confidence: 99%

Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications: a systematic review and meta-analysis

Alvares

Quintana

Hickie

et al. 2016

jpn

365

345

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“…In a recent study using Framingham risk estimates, Spanish patients with bipolar disorder were at greater risk for developing fatal or nonfatal coronary heart disease compared with the healthy population [21]. Using the Systematic Coronary Risk Evaluation function [22], the estimated risk of cardiovascular mortality was likewise elevated [23]. Those at risk for coronary heart disease and cardiovascular mortality according to the risk assessments had risk factors such as smoking, obesity, the metabolic syndrome, elevated total cholesterol, and reduced high-density lipoprotein cholesterol.…”

Section: Introductionmentioning

confidence: 99%

Mania and mortality: Why the excess cardiovascular risk in bipolar disorder?

Murray¹,

Weiner²,

Prabhakar³

et al. 2009

Curr Psychiatry Rep

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Individuals with bipolar disorder experience twice the cardiovascular mortality expected from general population estimates. The metabolic syndrome is more common in those with bipolar disorder, with a prevalence ratio of 1.6, and includes many traditional cardiovascular risk factors, which may explain much of the elevated risk. Manic symptom burden also predicts cardiovascular mortality, begging questions regarding other explanations for elevated cardiovascular risk. Ultimately, the mechanisms that lead to elevated cardiovascular risk in bipolar disorder are complex and potentially involve behavior, treatment, access to quality health care, and underlying pathophysiology. Much remains unknown about the etiology of any mechanisms inherent to illness or, for that matter, treatment effects. Addressing access and health behaviors can mitigate risk for individuals with bipolar disorder. Recent evidence indicates that psychiatrists are becoming aware of the vascular risk associated with bipolar disorder, although further education will improve monitoring and subsequent outcomes.

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Cardiovascular risk in patients with bipolar disorder

Cited by 67 publications

References 27 publications

Cardiovascular risk factors in outpatients with bipolar disorder: a report from the Brazilian Research Network in Bipolar Disorder

Cardiovascular risk factors in outpatients with bipolar disorder: a report from the Brazilian Research Network in Bipolar Disorder

Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications: a systematic review and meta-analysis

Mania and mortality: Why the excess cardiovascular risk in bipolar disorder?

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