Cardiovascular risk in carotid disease: assessment of doppler sonography and biomarker results

Oliveira, Rogério Jorge B. de; Santos, Alexandre Araújo Cunha dos; Santos, Lázaro Silveira; Vieira, Marcos Soares; Aras, Roque; Couto, Fábio David; Couto, Ricardo David

doi:10.1590/s1676-24442013000100003

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…CAD characterization was performed by two observers, to reduce bias and improve data quality, by using color unibidimensional doppler ultrasound (Envisor C series M2540A, PHILLIPS Medical Systems) as previously reported [20]. The stenotic degrees caused by atheroma plaques in carotid arteries were classified according to the North American Symptomatic Carotid Endarterectomy Trial (NASCET) [21]: level I (normal), level II (between 1% and 29%), level III (between 30% and 49%), level IV (between 50% and 69%), level V (between 70% and 99%) and level VI total occlusion (100%).…”

Section: Cad Characterizationmentioning

confidence: 99%

Matrix Metalloproteinases 2 and 9 are CAD More Relevant Biomarkers Than -1, -8, and -12 to Separate CAD from Non-CAD Patients

Fonseca¹,

Oliveira²,

Santos³

et al. 2019

TOBIOMJ

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Background: Atherosclerotic Carotid Artery Disease (CAD) is a frequent cause of mortality worldwide. The discovery of biomarkers that evidenced CAD progression would help with cardiovascular risk reduction. Extracellular Matrix Metalloproteinases (MMPs) have been associated with plaque progression, lesion aggravation, and rupture. Objective: This study evaluated that MMPs serum optical-densities and digestive gel-activity are associated with CAD. Methods: This cross-sectional study evaluated 65 outpatients presenting CAD (n=31) or not (n=34). The Carotid disease was evidenced by Doppler echography. ELISA and SDS-PAGE zymography were performed to determine MMPs serum optical-densities and proteolytic-activity. Principal Component Analysis (PCA) was performed to identify the most relevant MMPs (MMP-1, 2, 8, 9 and 12). Results: MMP-2 and MMP-9 showed lower serum optical-densities in CAD (MMP-2, p = 0.0246; and MMP-9, p < 0.0001), but higher digestive enzymatic activity when compared to non-CAD samples (p < 0.0001). PCA analysis strengthens the singling out of those individual MMPs as predictors of choice to differentiate CAD from non-CAD patients as opposed to others MMPs. Analysis of the loadings showed MMP-2 and MMP-9 as the most important independent variables to separate CAD from non-CAD patients. Conclusion: MMP-2 and MMP-9 are more relevant biomarkers for CAD than the other MMPs analyzed.

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Section: Cad Characterizationmentioning

confidence: 99%

Matrix Metalloproteinases 2 and 9 are CAD More Relevant Biomarkers Than -1, -8, and -12 to Separate CAD from Non-CAD Patients

Fonseca¹,

Oliveira²,

Santos³

et al. 2019

TOBIOMJ

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Transfer Proteins, Lipoprotein Remodeling, and Antioxidant Action on Pregnant Women: Comparison from the First to the Third Trimester of Gestation

Santos,

de Alcântara,

Soares

et al. 2023

TOBIOMJ

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Introduction: During pregnancy, maternal lipid metabolism undergoes several transformations originated by hormonal changes. There are two distinct phases: initial and late, finally driven to hypertriglyceridemia. Maternal hyperlipidemia, especially hypertriglyceridemia, is associated with an increased hepatic very-low-density lipoprotein (VLDL) synthesis stimulated by high estrogen levels during gestation. Objectives: This study aimed to evaluate the action of possible lipoproteins remodeling modulators, such as phospholipid and cholesteryl-ester transfer proteins (PLTP and CETP), paraoxonase-1 (PON-1), and apolipoproteins (apo), during gestation. Methods: An observational prospective cohort study composed of 40 pregnant women was conducted. Blood samples were collected in two moments: at the first and third trimesters of gestation, followed by the biochemical determination of apo A-I, apo B, lipid profile, PON-1, PLTP and CETP activities, and HDL particle size. Results: The majority of pregnant women in the third trimester showed dyslipidemia, mainly hypertriglyceridemia. In the third trimester of gestation, we observed an increase in CETP activity (70.5 ± 9.6 pmol/µL/h; p <0.001) and TG/HDL-C ratio (2.7 [2.0-3.8]), but on the other hand, PON-1 activity (65.4 [46.5-105] nMol of p-nitrophenol/min/mL) decreased. High-density level lipoprotein (HDL) particle size and PLTP activity did not differ in the two studied moments. The serum triglyceride concentration and CETP activity showed a positive linear correlation in the first trimester of gestation (r2=0.65, p<0.001). Conclusion: Data suggest that the CETP activity, antioxidant profile, and low-density lipoprotein (LDL) remodeling are modified by physiological metabolic changes during an uncomplicated gestational period.

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Cardiovascular risk in carotid disease: assessment of doppler sonography and biomarker results

Cited by 2 publications

References 30 publications

Matrix Metalloproteinases 2 and 9 are CAD More Relevant Biomarkers Than -1, -8, and -12 to Separate CAD from Non-CAD Patients

Matrix Metalloproteinases 2 and 9 are CAD More Relevant Biomarkers Than -1, -8, and -12 to Separate CAD from Non-CAD Patients

Transfer Proteins, Lipoprotein Remodeling, and Antioxidant Action on Pregnant Women: Comparison from the First to the Third Trimester of Gestation

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