Cardiovascular risk in an HIV-infected population in India

Marbaniang, Ivan; Kadam, Dileep; Suman, Rohan; Gupte, Nikhil; Salvi, Sonali; Patil, Sandesh; Shere, Dhananjay; Deshpande, Prasad; Kulkarni, Vandana; DeLuca, Andrea N.; Gupta, Amita; Mave, Vidya

doi:10.1136/heartasia-2017-010893

Cited by 16 publications

(11 citation statements)

References 21 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other authors have reported metabolic alterations, including lower HDL level in HIV-1-infected patients, when compared with healthy donors ( 37 ). Furthermore, the HDL deficiency is a factor that contributes to the high cardiovascular risk observed in patients with HIV-1 ( 38 ) and which is associated with the inflammatory process ( 39 ). Therefore, the aim of this study was to explore the association between HDL levels and the expression of inflammasome components and other inflammatory markers during HIV-1 infection.…”

Section: Introductionmentioning

confidence: 99%

Lower High-Density Lipoproteins Levels During Human Immunodeficiency Virus Type 1 Infection Are Associated With Increased Inflammatory Markers and Disease Progression

et al. 2018

View full text Add to dashboard Cite

IntroductionHigh-density lipoproteins (HDL) are responsible for the efflux and transport of cholesterol from peripheral tissues to the liver. In addition, HDL can modulate various immunological mechanisms, including the inflammatory response. Inflammasomes are multiprotein complexes that have been reported to be activated during human immunodeficiency virus type 1 (HIV-1) infection, thus contributing to immune hyperactivation, which is the main pathogenic mechanism of HIV-1 progression. However, the relationship between HDL and inflammasomes in the context of HIV-1 infection is unclear. Therefore, this research aims to explore the association between HDL and the components of the inflammatory response during HIV-1 infection.MethodologyA cross-sectional study, including 36 HIV-1-infected individuals without antiretroviral treatment and 36 healthy controls matched by sex and age, was conducted. Viral load, CD4+ T-cell counts, serum HDL, and C-reactive protein (CRP) were quantified. Serum cytokine levels, including IL-1β, IL-6, and IL-18, were assessed by ELISA. The inflammasome-related genes in peripheral blood mononuclear cells were determined by quantitative real-time PCR.ResultsHIV-1-infected individuals showed a significant decrease in HDL levels, particularly those subjects with higher viral load and lower CD4+ T-cell counts. Moreover, upregulation of inflammasome-related genes (NLRP3, AIM2, ASC, IL-1β, and IL-18) was observed, notably in those HIV-1-infected individuals with higher viral loads (above 5,000 copies/mL). Serum levels of IL-6 and CRP were also elevated in HIV-1-infected individuals. Significant negative correlations between HDL and the mRNA of NLRP3, AIM2, ASC, IL-1β, and IL-18, as well as viral load and CRP were observed in HIV-1-infected individuals. Likewise, a significant positive correlation between HDL and CD4+ T-cell counts was found.ConclusionIn summary, our results indicate that HDL might modulate the expression of several key components of the inflammasomes during HIV-1 infection, suggesting a novel role of HDL in modifying the inflammatory state and consequently, the progression of HIV-1 infection.

show abstract

Section: Introductionmentioning

confidence: 99%

Lower High-Density Lipoproteins Levels During Human Immunodeficiency Virus Type 1 Infection Are Associated With Increased Inflammatory Markers and Disease Progression

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Этот факт объясняется увеличением распространенности традиционных факторов риска, воспалительным и иммунологическим эффектами ВИЧ на эндотелий, а также влиянием АРТ [2,3]. ВИЧ-инфекция является отдельным фактором риска сердечно-сосудистой патологии [4]. У женщин детородного возраста с ВИЧ-инфекцией патология сердечно-сосудистой системы развивается чаще, чем у женщин без ВИЧ-инфекции [5], и интенсивнее, чем у мужчин [6].…”

Section: Hiv-associated Cardiovascular Pathologyunclassified

HIV-associated cardiovascular pathology

2019

View full text Add to dashboard Cite

АРТ-антиретровирусная терапия, ВИЧ-вирус иммунодефицита человека, ОХС-общий холестерин, СН-сердечная недостаточность, ХС ЛПВП-холестерин липопротеидов высокой плотности, ХС ЛПНП-холестерин липопротеидов низкой плотности, ХС ЛПОНП-холестерин липопротеидов очень низкой плотности, ХОБЛ-хроническая обструктивная болезнь легких, ЭКГ-электрокардиография, TFPI-ингибитор пути тканевого фактора, CCL24-лиганд 24 хемокина СС-модифицированного, NT-proBNP-N-терминальный фрагмент мозгового натрийуретического пептида, MBL2-лектин-2, связывающий маннозу, LTBR-бета-рецептор лимфотоксина, PCOLCE-интенсификатор эндопептидазы-С проколлагена.

show abstract

“…The QRISK score 3 is the latest version and includes both traditional risk factors (age, sex, ethnicity, cholesterol values, systolic blood pressure and antihypertensive treatment, smoking, diabetes, angina in a first-degree relative) and plenty of variables which are not included in other risk scores, such as atrial fibrillation, chronic kidney disease (stage 3, 4, or 5), migraine, corticosteroid therapy, systemic lupus erythematosus (SLE), atypical antipsychotics, severe mental illness, and erectile dysfunction in men [11]. The estimation of CVD risk by QRISK score has been poorly investigated in HIV-infected individuals [12].…”

Section: Introductionmentioning

confidence: 99%

Prediction of cardiovascular risk among male patients infected with human immunodeficiency virus in Vojvodina, Serbia: A single centre study

et al. 2019

View full text Add to dashboard Cite

Introduction. Human immunodeficiency virus infection is a disease of the modern era and it is estimated that there are more than 30 million infected individuals worldwide. Although the major cause is still unclear, patients infected with human immunodeficiency virus are at higher risk of ardiovascular diseases by 61% compared to general population. Material and Methods. This study included 111 male patients infected with human immunodeficiency virus treated at the Clinic of Infectious Diseases, Novi Sad, Serbia from January 2008 to December 2018. Five cardiovascular risk scores were used: Data Collection on Adverse Events of Antihuman immunodeficiency virus Drugs, Framingham 10-year Heart Score, Framingham 5-year Heart Score, prediction algorithm for cardiovascular disease and atherosclerotic cardiovascular disease risk estimator, at the beginning of the treatment, whereas cardiovascular events were recorded during the following 10 years. Results. Data Collection on Adverse Events of Anti-human immunodeficiency virus Drugs, Framingham 10-year Heart Score, Framingham 5-year Heart Score, and prediction algorithm for cardiovascular disease are tools that can identify individuals infected with human immunodeficiency virus at cardiovascular risk with statistical significance. The prediction algorithm for cardiovascular disease provides superior risk estimation compared to other scores. The atherosclerotic cardiovascular disease risk estimator did not show to be a marker of cardiovascular risk prediction among this population of patients. Conlusion. The above mentioned cardiovascular risk prediction algorithms, developed for general population, and Data Collection on Adverse Events of Anti-human immunodeficiency virus Drugs score, specific for population infected with human immunodeficiency virus, allow accurate cardiovascular risk estimation. Until the development of more specific algorithms, these scores are adequate tools for identification of patients at risk, providing prevention measures and treatment of cardiovascular disease.

show abstract

Cardiovascular risk in an HIV-infected population in India

Abstract: CVD at younger ages among Asian Indian people living with HIV appear to be an imminent risk for morbidity. Stepping up of preventive services including screening services and prescription of statins are important strategies that must be considered.

Cited by 16 publications

References 21 publications

Lower High-Density Lipoproteins Levels During Human Immunodeficiency Virus Type 1 Infection Are Associated With Increased Inflammatory Markers and Disease Progression

Lower High-Density Lipoproteins Levels During Human Immunodeficiency Virus Type 1 Infection Are Associated With Increased Inflammatory Markers and Disease Progression

HIV-associated cardiovascular pathology

Prediction of cardiovascular risk among male patients infected with human immunodeficiency virus in Vojvodina, Serbia: A single centre study

Contact Info

Product

Resources

About