Cardiovascular Risk Factors in Younger Black Women: Results from the 10,000 Women Community Screening Project

Vatsa, Nishant; Thobani, Aneesha; Buendia, Laura; Murphy, Karleigh; Asier, Senait; Chen, Zhenchao; Ko, Yi‐An; Putnam, Tyler; Mehta, Puja K.; Lundberg, Gina

doi:10.1016/j.ahjo.2021.100037

Cited by 6 publications

(6 citation statements)

References 32 publications

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“…According to NHANES 2015–2018 data, the prevalence of HTN in African American women 20 years and older exceed both non-Hispanic White and Hispanic women, respectively (51%, 40.8%, 57.6%) [ 1 ]. African American women also have a higher prevalence of comorbidities such as obesity, diabetes, and chronic kidney disease [ 1 , 3 – 5 ], are less likely to engage in health behaviors that reduce CVD risk [ 6 ], and are less likely to be aware of HTN as a heart disease risk factor [ 7 ]. Furthermore, this group is more likely to experience socioeconomic adversity compared to white women [ 8 – 10 ]; even so, higher socioeconomic status (SES) African American women are less likely to experience health gains from their socioeconomic resources compared to white women of similar or equal SES [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Socioeconomic characteristics of African American women attending community blood pressure screenings

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Isiadinso

Mehta

et al. 2022

American Heart Journal Plus: Cardiology Research and Practice

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Section: Introductionmentioning

confidence: 99%

Socioeconomic characteristics of African American women attending community blood pressure screenings

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Isiadinso

Mehta

et al. 2022

American Heart Journal Plus: Cardiology Research and Practice

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Section: Resultsmentioning

confidence: 92%

“…Clinical and lipidomic data was available for 695 White and 179 Black women of which 411 and 137 had HBP, respectively. White women with HBP were significantly older than all other groups ( P <0.001), reflecting the national trend of higher CVD rates in Black women at younger ages than other races (30). Similar to SHOW, all groups had median WC indicative of obesity, though Black women had notably higher WC (median>98 cm) than White women (<94 cm) regardless of BP status.…”

Section: Resultsmentioning

confidence: 95%

Identification of novel plasma lipid markers of cardiovascular disease risk in White and Black women

Jain

Davidson

Gonzalez

et al. 2022

Preprint

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Rationale: Cardiovascular disease (CVD) is the leading cause of mortality for women in the USA. Current clinical biomarkers are inadequate to determine CVD risk in women, especially Black women, who disproportionately suffer from CVD. Methods: Clinical data and LC-MS lipidomics from two independent study cohorts were used to identify novel circulating markers of CVD risk in White and Black women. Machine learning assessed predictive efficacy of identified lipids, and targeted oxylipid analysis provided insight into dysregulated inflammatory pathways. Results: Select phospholipids and triglycerides containing acyl chains in the arachidonic acid (ARA) pathway were predictive of systolic blood pressure (BP) after adjusting for biological factors including age, obesity, and glycemic status in White and Black women. Oxylipid levels indicated increased conversion of ARA through the COX and LOX enzymes to pro-inflammatory cytokines in Black women. Conclusion: ARA-containing phospholipid are independent predictors of CVD risk in White and Black women. Predisposition to CVD risk in Black women may further be explained by increased production of pro-inflammatory oxylipids relative to White women, regardless of blood pressure status. Future studies investigating the clinical utility of phospholipid ARA abundance as a marker of CVD risk in White and Black women are warranted.

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“…In addition, AA women have nearly twice the age-adjusted death rate attributable to HTN, although this and other CVD risk factors are often undertreated in AA women. A recent community-based CVD risk factor screening study in 945 AA women found that elevated blood pressure and obesity were prevalent at younger ages [18]. Older and AA women are particularly susceptible to increased risk from heart failure, stroke, and renal disease due to HTN [19].…”

Section: Hypertension (Htn)mentioning

confidence: 99%

Traditional and Emerging Sex-Specific Risk Factors for Cardiovascular Disease in Women

Mehta¹,

Gaignard²,

Schwartz³

et al. 2022

Rev. Cardiovasc. Med.

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Cardiovascular disease (CVD) remains a major health threat in women. While traditional CVD risk factors such as hypertension, hyperlipidemia, diabetes, and smoking have been recognized for over 50 years, optimal control of these risk factors remains a major challenge. Unique sex-specific risk factors such as adverse pregnancy outcomes, premature menopause and low estrogen states, and chronic autoimmune inflammatory disorders also contribute to increased CVD risk in women. In addition, psychological risk factors such as stress, depression, and social determinants of health may have a disproportionately adverse impact in women. An improved understanding of traditional and emerging sex-specific CVD risk factors and management of modifiable factors is critical for clinicians who provide care for women. Early recognition and treatment of risk factors may alter the trajectory of adverse CVD events. A multi-disciplinary approach with team-based care involving multiple specialists and improved, targeted educational efforts are needed to reduce CVD risk factors and its adverse consequences in women.

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Cardiovascular Risk Factors in Younger Black Women: Results from the 10,000 Women Community Screening Project

Cited by 6 publications

References 32 publications

Socioeconomic characteristics of African American women attending community blood pressure screenings

Socioeconomic characteristics of African American women attending community blood pressure screenings

Identification of novel plasma lipid markers of cardiovascular disease risk in White and Black women

Traditional and Emerging Sex-Specific Risk Factors for Cardiovascular Disease in Women

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