Cardiovascular Risk Factors in Patients with Lichen Planus

Arias‐Santiago, Salvador; Buendía‐Eisman, A.; Aneiros‐Fernández, José; Girón-Prieto, María Sierra; Gutiérrez-Salmerón, María Teresa; Mellado, Valentín García; Naranjo‐Sintes, Ramón

doi:10.1016/j.amjmed.2010.12.025

Cited by 87 publications

(144 citation statements)

References 16 publications

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“…In their study according to ATP III criteria for MS, only 27% of patients with lichen planus had MS while that in the control group was 20%.This was insignificant with a p value of 0.310. 7 In a study done by Baykal et al, out of the 79 patients with LP, 26% had metabolic syndrome when compared to 12% of the control group. They also concluded that presence of mucosal LP has an even higher risk of developing metabolic syndrome.…”

Section: Metabolic Syndromementioning

confidence: 99%

“…17 However this was not in accordance with the study done by Salvador Arias-Santiago et al were they could not prove any association between LP and hypertension. 7 …”

Section: Blood Pressurementioning

confidence: 99%

“…17 In addition to metabolic syndrome as a whole, there are studies describing higher incidence of individual components like raised waist circumference, hypertension, low HDLC, raised triglycerides and raised fasting blood glucose in LP patients. 7 In our study we have tried to find out the presence of any association between lichen planus and metabolic syndrome.…”

Section: Clinical Patterns Of Lichen Planus In the Studymentioning

confidence: 99%

“…Inflammation produces alteration of lipid metabolism such as increase in serum triglycerides or decrease in high-density lipoprotein cholesterol. 7 It has been proposed that immunological defect in endocrine dysfunction causing diabetes mellitus may also contribute to development of lichen planus. In 1963, Grinspan found an association between oral lichen planus, diabetes mellitus and hypertension and named it as Grinspan syndrome.…”

Section: Introductionmentioning

confidence: 99%

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A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

2017

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Background: Lichen planus is an autoimmune, inflammatory papulosquamous disease affecting skin and mucous membrane with a possible association with the parameters of metabolic syndrome.Methods: We carried out a hospital based case control study among patients attending DVL OPD during a period of 1.5 years (January 2015 - May 2016). Study population included 40 cases of LP and 80 age and sex matched controls. Relevant history, clinical examination and blood investigations were done. Diagnosis of MS was made based on IDF criteria.Results: There was no significant association between metabolic syndrome and lichen planus (p=0.292). Although there was higher prevalence of hypertension (47.5% vs. 27.5%, p=0.029), triglyceride level (25% vs. 10%, p=0.030) and low HDLC levels (65% vs. 45%, p=0.039). We could not establish significant association between FBS and waist circumference with LP.Conclusions: Though metabolic syndrome was not significantly associated with LP, its components such as hypertension, triglycerides and low HDLC levels were significantly associated with LP as per the study. Therefore patients with LP need to be screened to rule out each of these parameters to avoid later complications.

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Section: Metabolic Syndromementioning

confidence: 99%

“…17 However this was not in accordance with the study done by Salvador Arias-Santiago et al were they could not prove any association between LP and hypertension. 7 …”

Section: Blood Pressurementioning

confidence: 99%

Section: Clinical Patterns Of Lichen Planus In the Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

2017

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“…La afectación leve y temporal de la lámina ungueal se da entre el 1% y el 10% de los casos aunque en aproximadamente un 4% ocasiona un daño irreversible 5 . En España se ha detectado una asociación significativa entre el LP y la dislipemia 6 , de hecho se cree que la inflamación crónica presente en personas afectadas de liquen plano sería la responsable de su relación con la dislipemia según un estudio de casos y controles que tuvo por objeto evaluar los factores de riesgo cardiovascular incluidos en el documento Adult Treatment Panel III (ATP-III) 7 . La prevalencia exacta del LP es desconocida sin embargo, a nivel mundial, se estima que fluctua entre el 0,22% y el 5% 8 .…”

Section: Introductionunclassified

Líquen plano hipertrófico. A propósito de un caso

Rey

Casabella

Sánchez

et al. 2015

Rev. Int. Cienc. Podol.

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Metabolic syndrome in patients with lichen planus: A case‐control study

Mathur,

Thakur,

Jaiswal

et al. 2023

Skin Health and Disease

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BackgroundLichen Planus (LP) is a chronic dermatosis affecting the skin and mucous membranes. Chronic inflammation and oxidative stress in patients with LP is a trigger predisposing to Metabolic Syndrome.ObjectivesTo study the association of Metabolic Syndrome in patients with LP.Materials and MethodsA hospital‐based prospective case‐control study was conducted from April 2021 to January 2023 including 75 histopathologically confirmed patients with LP and 82 age and sex‐matched controls according to the inclusion and exclusion criteria. Metabolic Syndrome was diagnosed using Modified National Cholesterol Education Programme Adult Treatment Panel III criteria. Statistical analysis of the data was performed using Statistical Package for the Social Sciences software, version 26. The chi‐square test was used for data analysis.ResultsThe majority (30.6%) of the patients belonged to the age group 31–40 years. The mean age of patients with LP was 46.13 ± 14.9 years. Female predominance (69.3%) was observed in our study. Patients with classic LP (54.6%) were predominantly observed. Metabolic Syndrome was significantly prevalent in LP patients than in controls (32% vs. 13.4%, p = 0.005, OR 3.037) and was significantly associated with morphology (only oral mucosal involvement, 61.5%, p 0.027, OR 3.9), severity (severe LP, 58.6%, p < 0.001, OR 7.79), and duration of the disease (≥6 months, 55.5%, p 0.001, OR 5.42). 71% of Metabolic Syndrome was observed in females (p 0.847). Among patients with metabolic syndrome, the majority belonged to the age group between 31 and 40 years (37.5%, p 0.378). Systolic and Diastolic Blood Pressure values (≥130/85 mm of Hg), Serum Triglycerides (≥150 mg/dl), and Low‐Density Lipoprotein (>130 mg/dl) were significantly elevated, and High‐Density Lipoprotein (<40 mg/dl) was significantly low in LP than in controls (p < 0.05).ConclusionThe study showed a significant association of Metabolic Syndrome in patients with LP. Thus, patients with LP need to be screened to avoid complications associated with Metabolic Syndrome that is, Diabetes Mellitus, Cardiovascular Disease, colorectal cancer, and stroke.

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Cardiovascular Risk Factors in Patients with Lichen Planus

Cited by 87 publications

References 16 publications

A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

Líquen plano hipertrófico. A propósito de un caso

Metabolic syndrome in patients with lichen planus: A case‐control study

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