Cardiovascular risk factors in first degree relatives of patients with premature coronary artery disease

Saghafi, H; Mahmoodi, Mohammad Jaafar; Fakhrzadeh, Hossein; Heshmat, Ramin; Shafaee, A; Larijani, Bagher

doi:10.2143/ac.61.6.2017959

Cited by 11 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…19 Saghafi et al found prevalence of hypertension in firstdegree relatives men as 53.2% and women 24.7%. 12 Kang et al study in first-degree relative showed hypertension prevalence as 25% and mean systolic blood pressure as 132 ± 19 mmHg which is comparable to present study mean of 136 ± 7 mmHg. 18 Around 14% males belonged to the hypertensive group, whereas only 5% females had hypertension in the study.…”

Section: Ethical Issuessupporting

confidence: 87%

“…19 In study of Saghafi et al over weight prevalence in first-degree relatives men was 56.3% and women 39.7% which is also comparable to this study findings. 12 Among 33% of study subjects had self-reported history of hypertension, 71% were pre hypertensive and 29.2% were hypertensive grade1. About…”

Section: Discussionmentioning

confidence: 92%

“…To detect the prevalence of at least one risk factor among first degree relative as 91% with 5% absolute precision and 99% CI, minimum sample needed was 218. 12 The study was approved by institute ethics committee.…”

Section: Study Settingmentioning

confidence: 99%

See 2 more Smart Citations

Cardiovascular Disease Risk Profiling Among First Degree Relatives of Coronary Artery Disease Patients Admitted in Cardiology Ward of JIPMER, Puducherry

Soman¹,

Kar²,

Satheesh³

et al. 2016

JCDR

View full text Add to dashboard Cite

BACKGROUND Non communicable diseases like cardio vascular disorders, cancer, respiratory disorders and diabetes constitute 68% of global death annually. Among this 40% of deaths were in age group 30 to 70 years. CVDs alone constitute 31% of global deaths making it the leading cause of death. According to "WHO global status report on non-communicable diseases" published in 2014, deaths due to non-communicable diseases will increase from 38 million to 52 million in 2030 and more than 23 million may die annually due to cardio vascular diseases alone. Meanwhile in India non communicable diseases accounts for 60 per cent of all deaths and cardio vascular diseases alone contributes to 26 per cent of Indian mortality. In rural India due to poor health infrastructure cardiovascular events are found to be higher compared to urban counterparts. Across the globe also peak has shifted from developed to developing countries. 1-4 INTERHEART study to identify risk factors for is chemic heart disease revealed that sedentary lifestyle, smoking, hypertension, psychosocial stress, abnormal lipids, diabetes, high waist-hip ratio, and a lack of consumption of vegetables and fruits are the cause of more than 90% of acute coronary heart disease events in South Asians. 5 In General cardiovascular risk factors can be broadly classified as 1) behavioural (tobacco use, alcohol consumption, unhealthy diet, inadequate physical activity) 2) physical (high BMI, waist circumference, elevated blood pressure) and3) biochemical (elevated blood glucose, elevated blood lipids). Due to several genetic and environmental factors population, first degree relatives of patients with coronary heart disease have a significant higher risk of getting cardiovascular events. This excessive risk is due to interplay between genetic as well as environmental factors. Clustering of various risk factors such as eating and life style habits, socioeconomic status, exercise pattern and disease process like dyslipidemia, hypertension, defects in glucose metabolism make family members more prone to similar non-communicable diseases. 6 WHO and National Programme for prevention of Cancer, Diabetes, Cardiovascular diseases and Stroke (NPCDCS) proposed opportunistic screening (screen adults wherever there is an opportunity of contact with the health system) as a main strategy to prevent NCDs. But in clinical setting any advice on life style modification or active intervention to manage risk factors are rarely given to family members .It was documented that only 17.8% of Coronary Artery Disease (CAD) patients had their family members screened for various risk factors. 7 Currently, NCD prevention strategies are focusing more on integrated risk factor approach than individual risk factor. World Health Organization/ International Society of Hypertension (WHO/ISH) risk prediction charts assist in the estimation of 10-year risk of a fatal or non-fatal major cardiovascular event (stroke or myocardial infarction), based on age, gender, presence or absence of diabetes mellitus, smokin...

show abstract

Section: Ethical Issuessupporting

confidence: 87%

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Cardiovascular Disease Risk Profiling Among First Degree Relatives of Coronary Artery Disease Patients Admitted in Cardiology Ward of JIPMER, Puducherry

Soman¹,

Kar²,

Satheesh³

et al. 2016

JCDR

View full text Add to dashboard Cite

show abstract

“…Individuals who smoked regularly during the previous 12 months were classified as smokers. Other risk factors as lack of exercise and family history of premature CAD (first degree male relatives <55 years or females <65 years) were documented [29]. …”

Section: Methodsmentioning

confidence: 99%

Atherosclerotic and thrombotic genetic and environmental determinants in Egyptian coronary artery disease patients: a pilot study

Fawzy

Toraih

Aly

et al. 2017

BMC Cardiovasc Disord

View full text Add to dashboard Cite

BackgroundCoronary artery disease (CAD) is the leading cause of morbidity and mortality worldwide. Multiple genetic variants in combination with various environmental risk factors have been implicated. This study aimed to investigate the association of twelve thrombotic and atherosclerotic gene variants in combination with other environmental risk factors with CAD risk in a preliminary sample of Egyptian CAD patients.MethodsTwenty three consecutive CAD patients undergoing diagnostic coronary angiography and 34 unrelated controls, have been enrolled in the study. Genotyping was based on polymerase chain reaction and reverse multiplex hybridization. Five genetic association models were tested. Data distribution and variance homogeneity have been checked by Shapiro-Wilk test and Levene test, respectively; then the appropriate comparison test was applied. Spearman’s rank correlation coefficient was used for correlation analysis and logistic regression has been performed to adjust for significant risk factors. Clustering the study participants according to gene-gene and gene-environment interaction has been done by Detrended Correspondence Analysis (DCA).ResultsThe univariate analysis indicated that the five variants; rs1800595 (FVR2; factor 5), rs1801133 (MTHFR; 5,10-methylenetetrahydrofolate reductase), rs5918 (HPA-1; human platelet antigen 1), rs1799752 (ACE; angiotensin-converting enzyme), and rs7412 and rs429358 (ApoE; apolipoprotein E) were significantly associated with CAD susceptibility under different genetic models. Multivariate analysis revealed clustering of the study population into three patient groups (P) and one control group. FVR2 was the most variant associated with CAD patients, combined with the factor V Leiden (FVL) variant in P1 cluster and with both ACE and MTHFR 667C > T in P2. Whereas, P3 was mostly affected by both MTHFR 667C > T and FXIII (factor 13) V89L mutations. When combined with traditional risk factors, P1 was mostly affected by dyslipidemia, smoking and hypertension, while P2 was mostly affected by their fasting blood sugar levels and ApoE variant.ConclusionsTaken together, these preliminary results could have predictive value to be applied in refining a risk profile for our CAD patients, in order to implement early preventive interventions including specific antithrombotic therapy. Further large scale and follow-up studies are highly recommended to confirm the study findings.Electronic supplementary materialThe online version of this article (doi:10.1186/s12872-016-0456-3) contains supplementary material, which is available to authorized users.

show abstract

“…Em contrapartida, alguns autores referem alterações glicêmicas em menos de 10% dos familiares de primeiro grau. 125 A elevada presença de sobrepeso/obesidade e SM neste grupo possivelmente justifica este achado.…”

Section: Avaliação Da Associação Entre Função Tireoidiana E Parâmetrounclassified

Marcadores de risco cardiovascular em indivíduos com infarto do miocárdio precoce e em seus familiares de primeiro grau

Gurgel¹

View full text Add to dashboard Cite

show abstract

Cardiovascular risk factors in first degree relatives of patients with premature coronary artery disease

Abstract: The prevalence of coronary risk factors among first-degree relatives of patients with premature CAD is high, especially in men. Risk factor identification and modification should be considered in individuals with a positive family history of premature CAD.

Cited by 11 publications

References 0 publications

Cardiovascular Disease Risk Profiling Among First Degree Relatives of Coronary Artery Disease Patients Admitted in Cardiology Ward of JIPMER, Puducherry

Cardiovascular Disease Risk Profiling Among First Degree Relatives of Coronary Artery Disease Patients Admitted in Cardiology Ward of JIPMER, Puducherry

Atherosclerotic and thrombotic genetic and environmental determinants in Egyptian coronary artery disease patients: a pilot study

Marcadores de risco cardiovascular em indivíduos com infarto do miocárdio precoce e em seus familiares de primeiro grau

Contact Info

Product

Resources

About