Cardiovascular risk factors in elderly : With special emphasis on atrial fibrillation, hypertension and diabetes

Rådholm, Karin

doi:10.3384/diss.diva-121286

Cited by 3 publications

(2 citation statements)

References 155 publications

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“…Other studies have showed that high expression of ACE2 in the patients with hypertension, diabetes, and cardiovascular diseases might facilitate SARS-CoV-2 to enter the targeted cells in the respiratory system, and prolong the time of viral clearance [11, 31]. On the other hand, old people usually have a high risk of in hypertension, diabetes, and cardiovascular diseases [32], making age and these diseases difficult to discern.…”

Section: Discussionmentioning

confidence: 99%

Hypertension and Diabetes Delay the Viral Clearance in COVID-19 Patients

Chen

Ling

et al. 2020

Preprint

100

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2 6 Sweden 2 7 2 8 Abstract = 186 words, Main text = 1722 words, Figures =2. Abstract 3 0 Objectives: Comorbidities have significant indications for the disease outcome of COVID-19, 3 1 however which underlying diseases that contribute the most to aggravate the conditions of 3 2 COVID-19 patients is still largely unknown. SARS-CoV-2 viral clearance is a golden standard 3 3 for defining the recovery of COVID-19 infections. To dissect the underlying diseases that 3 4 could impact on viral clearance, we enrolled 106 COVID-19 patients who were hospitalized in 3 5 Methodology: We comprehensively analyzed demographic, clinical and laboratory data, as 3 8 well as patient treatment records. Survival analyses with Kaplan-Meier and Cox regression 3 9 modelling were employed to identify factors influencing the viral clearance negatively. 4 0 Results: We found that increasing age, male gender, and angiotensin-converting enzyme 2 4 1 (ACE2) associated factors (including hypertension, diabetes, and cardiovascular diseases) 4 2 adversely affected the viral clearance. Furthermore, analysis by a random forest survival 4 3 model pointed out hypertension, cortisone treatment, gender, and age as the four most 4 4 important variables. 4 5 Conclusions: We conclude that patients at old age, males, and/or having diseases 4 6 associated with high expression of ACE2 will have worse prognosis during a COVID-19 4 7 infections. 4 8 4 9

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Section: Discussionmentioning

confidence: 99%

Hypertension and Diabetes Delay the Viral Clearance in COVID-19 Patients

Chen

Ling

et al. 2020

Preprint

100

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“…On the other hand, the males and elderly usually had a high risk of hypertension, 26 making it difficult to discern. According to the univariable analysis, we also found that male and elderly (≥60 years) were significantly related to longer viral shedding.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for the delayed viral clearance in COVID‐19 patients

Chen

Yang

et al. 2021

J of Clinical Hypertension

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Comorbidities are important for the disease outcome of COVID‐19, however, which underlying diseases that contribute the most to aggravate the conditions of COVID‐19 patients are still unclear. Viral clearance is the most important laboratory test for defining the recovery of COVID‐19 infections. To better understand which underlying diseases that are risk factors for delaying the viral clearance, we retrospectively analyzed 161 COVID‐19 clinical cases in the Zhongnan Hospital of Wuhan University, Wuhan, China between January 5 and March 13, 2020. The demographic, clinical and laboratory data, as well as patient treatment records were collected. Univariable and multivariable analysis were performed to explore the association between delayed viral clearance and other factors by using logistic regression. Survival analyses by Kaplan‐Meier and Cox regression modeling were employed to identify factors negatively influencing the viral clearance negatively. We found that hypertension and intravenous immunoglobulin adversely affected the time of viral RNA shedding. Hypertension was the most important risk factor to delay the SARS‐CoV‐2 virus clearance, however, the use of Angiotensin‐Converting Enzyme Inhibitors(ACEI)/Angiotensin Receptor Blockers(ARB) did not shorten the time for virus clearance in these hypertensive patients’ virus clearance. We conclude that patients having hypertension and intravenous immunoglobulin may delay the viral clearance in COVID‐19 patients.

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The Socio-Demography, Clinical Characteristics and the Prevalence of Cardiovascular Risk Factors Among a Group of Elderly Hypertensive Patients Followed Up at A Tertiary Care Hospital in Sri Lanka.

Ralapanawa¹,

Tennakoon

Jayalath³

et al. 2017

JCCI

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Background Hypertension is one of the most prevalent risk factors for myocardial infarction, strokes, congestive cardiac failure and chronic kidney disease (CKD)and its prevalence is significantly higher inthe elderly population. Objectives To assess the demography, various presentations and the prevalence of risk factors among elderly hypertensive patients followed up in a tertiary care hospital in Sri Lanka. Materials and Methods This was a cross sectional descriptive study involving 250 patients whoseage was 60 years or above onantihypertensives for at least 6 months. Results Approximately 65.2% of the study population was female. The mean age was 70.17.Dizziness and chest pain were the most prevalent symptoms.The mean age at first detection was 58.17 years.Mean SBP and DBP were 128.5mmHg and 81.14mmHg respectively. The prevalence of alcohol consumption and smoking among men were 70.1% and 72.4% respectively. Approximately 54.7% were either overweight or obese.Approximately 81.6% females and 41.4% males had a waist circumference ofmore than therisk level with p-value<0.05. Approximately 36% had diabetes mellitus and 27.6% of the patients had at least one parent and 36.8% had at least one sibling diagnosed with hypertension. Approximately 61.3% of the patients hadadequate levels of physical activity while 31.8% had IHD,11.5% had stroke and 3.8% had CKD. Conclusion Dizziness and chest pain were the most disturbing symptoms while abdominal obesity among females,and alcohol consumption and smoking among males were the major risk factors in elderly hypertensive patients

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Cardiovascular risk factors in elderly : With special emphasis on atrial fibrillation, hypertension and diabetes

Cited by 3 publications

References 155 publications

Hypertension and Diabetes Delay the Viral Clearance in COVID-19 Patients

Hypertension and Diabetes Delay the Viral Clearance in COVID-19 Patients

Risk factors for the delayed viral clearance in COVID‐19 patients

The Socio-Demography, Clinical Characteristics and the Prevalence of Cardiovascular Risk Factors Among a Group of Elderly Hypertensive Patients Followed Up at A Tertiary Care Hospital in Sri Lanka.

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