Cardiovascular risk factors associated with enlarged diameter of the abdominal aortic and iliac arteries in healthy women

Patel, Ami; Mackey, Rachel H.; Wildman, Rachel P.; Thompson, Trina; Matthews, Karen A.; Kuller, Lewis H.; Sutton-Tyrrell, Kim

doi:10.1016/j.atherosclerosis.2004.08.026

Cited by 19 publications

(32 citation statements)

References 38 publications

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“…Both the number of AACs and the size of the existing baseline AACs increased, which indicate the possibility to derive new information about disease progression based on the growth of the existing AACs. Table 5 The table shows Subject-specific models of the disease progression At present, the standard clinical practice is based on quantifying the severity of atherosclerosis, calculating the amount of calcified plaques, determining the narrowing of the aortic luminal, or calculating the intima-media thickness using X-ray, US, CT, or IVUS [25,6,26,22,23,27,17,16]. We believe that assessment of the growth potential of individual plaques could provide us with more understanding of the disease development, and this could lead to better tools for future risk assessment in patients suffering from atherosclerosis.…”

Section: The Number Of Aacs Increasedmentioning

confidence: 99%

“…These programs could potentially be used for advancing the growth analysis. Likewise, there exists numerous longitudinal studies of how carotid atherosclerosis can predict myocardial infarction based on US imaging [16,17,29]. These US images could, possibly, also be used to derive growth patterns of the individual AACs, but in the current study we have focused on the X-ray images.…”

Section: Longitudinal Studymentioning

confidence: 99%

“…This study is based on X-rays images due to the historical X-ray data we have access to, but alternatively ultrasound (US) imaging could be used for identification of the growth patterns. US produces no ionising radiation and is therefore suitable for use in evaluation and monitoring of carotid atherosclerosis in large scale longitudinal studies and in clinical management of patients at risk of stroke [16,17,18]. US is also used, routinely, for vascular assessment and screening for abdominal aortic aneurysms [19,20,21].…”

Section: Introductionmentioning

confidence: 99%

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Growth patterns of abdominal atherosclerotic calcified deposits from lumbar lateral X-rays

Lillemark

Ganz

Barascuk

et al. 2010

Int J Cardiovasc Imaging

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The aim of this study is to investigate new methods for describing the progression of atherosclerosis based on novel information of the growth patterns of individual abdominal aortic calcifications (AACs) over time. Lateral X-ray images were used due to their low cost, fast examination time, and wide-spread use, which facilitates a large statistical model (n > 100) based on longitudinal data. The examined cohort consisted of 103 post-menopausal women aged 62.4 years (± 7.0 years) with an average number of AACs of (4.7 ± 8.0) at baseline. The subjects had X-ray images taken in 1992-1993 (baseline) and again in 2000-2001 (follow-up). The growth patterns of the individual AACs were derived based on registered baseline and follow-up images. Area, height, width, centre of mass position, and movement of the centre of mass, and upper and lower boundary of the matched AACs were measured. The AACs occurred first, mainly, on the posterior aortic wall. The AACs grew on average 41 in the longitudinal direction and 21 in the radial direction. A correlation of 0.48 (P < 0.001) between growth in width and height of the AACs was present. The centre of mass of the AACs moved 0.60 mm (P < 0.001) downstream in the aorta, on average. The growth patterns of AACs may give new insights into the progression of atherosclerosis. The downstream asymmetry in the growth patterns indicates variability in microscopic environments around the AACs.

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Section: The Number Of Aacs Increasedmentioning

confidence: 99%

Section: Longitudinal Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Growth patterns of abdominal atherosclerotic calcified deposits from lumbar lateral X-rays

Lillemark

Ganz

Barascuk

et al. 2010

Int J Cardiovasc Imaging

View full text Add to dashboard Cite

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“…3 However, there are limited studies on the epidemiology of aortic diameter. [4][5][6] Risk factors and potential alternative pathomechanisms for the development of infrarenal aortic dilatation need to be further explored.…”

Section: Introductionmentioning

confidence: 99%

“…6 Although high lipid levels are known to be related to the development of atherosclerosis, results of previous studies on the association between abdominal aortic diameter and lipid profile have been inconsistent. 5,6 Jian-an Wang and Xiao-feng Chen contributed equally to this work.…”

Section: Introductionmentioning

confidence: 99%

Relationship of heavy drinking, lipoprotein (a) and lipid profile to infrarenal aortic diameter

Wang

Chen

et al. 2009

Vasc Med

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The objective of this study was to examine the association of alcohol drinking and lipid profile with infrarenal aortic dimension. The diameter of the infrarenal aorta was measured using ultrasound in 395 individuals (mean 66.6 ± 10.3 years) with atherosclerotic diseases or risk factors. The associations between heavy drinking, serum lipoprotein (a) levels, lipid profile and infrarenal aorta diameters were examined. Heavy drinking and lipoprotein (a) were positively related with infrarenal aortic dimension, while low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C), LDL-C and total cholesterol (TC)/HDL-C were negatively associated with infrarenal aortic diameter (p < 0.05). In addition, there were negative associations of LDL-C/HDL-C, TC/HDL-C and positive associations of HDL-C and apolipoprotein AI (Apo AI) with heavy drinking (p < 0.05). In conclusion, there was a positive association between infrarenal aortic diameters and heavy drinking, as well as lipoprotein (a) levels. Furthermore, the novel and unexpected inverse association between LDL-C/HDL-C, LDL-C, TC/HDL-C and abdominal aortic diameter may suggest a possible role for antiatherogenic lipid profile (characterized by a higher level of HDL-C and lower level of LDL-C) in aortic dilatation processes, which need to be clarified by further studies.

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The validity of arterial measurements in a South African embalmed body population

et al. 2017

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With the exception of two measurements, measurements in embalmed bodies and living people are interchangeable and concerns regarding the effect of distortion and shrinkage are unfounded. Even small changes in arterial diameter greatly influence blood flow and blood pressure, which contribute to undesirable clinical outcomes such as aortic aneurysms and aortic dissections. This study completes the first step towards the development of a reference database against which to compare the diameters of arteries in a variety of pathological conditions in a South African population.

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Cardiovascular risk factors associated with enlarged diameter of the abdominal aortic and iliac arteries in healthy women

Cited by 19 publications

References 38 publications

Growth patterns of abdominal atherosclerotic calcified deposits from lumbar lateral X-rays

Growth patterns of abdominal atherosclerotic calcified deposits from lumbar lateral X-rays

Relationship of heavy drinking, lipoprotein (a) and lipid profile to infrarenal aortic diameter

The validity of arterial measurements in a South African embalmed body population

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