Cardiovascular Risk Factors and the Severity of COVID-19 Disease

Motaib, Imane; Zbiri, Saad; Elamari, Saloua; Haoudar, Amal; Chadli, Asma; Kettani, Chafik El

doi:10.7759/cureus.15486

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…The level of AOPPs is raised in many diseases, including renal failure, diabetes, and atherosclerosis, but also increases with age [ 66 , 67 , 68 ]. Very often, a severe course of COVID-19 is associated with comorbidities [ 69 , 70 ]. Therefore, an elevated AOPPs level prior to infection may also be a risk factor for severe COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Study of Albumin Oxidation in COVID-19 Pneumonia Patients: Possible Mechanisms and Consequences

Wybranowski

Napiórkowska

Bosek

et al. 2022

IJMS

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Oxidative stress induced by neutrophils and hypoxia in COVID-19 pneumonia leads to albumin modification. This may result in elevated levels of advanced oxidation protein products (AOPPs) and advanced lipoxidation end-products (ALEs) that trigger oxidative bursts of neutrophils and thus participate in cytokine storms, accelerating endothelial lung cell injury, leading to respiratory distress. In this study, sixty-six hospitalized COVID-19 patients with respiratory symptoms were studied. AOPPs-HSA was produced in vitro by treating human serum albumin (HSA) with chloramine T. The interaction of malondialdehyde with HSA was studied using time-resolved fluorescence spectroscopy. The findings revealed a significantly elevated level of AOPPs in COVID-19 pneumonia patients on admission to the hospital and one week later as long as they were in the acute phase of infection when compared with values recorded for the same patients 6- and 12-months post-infection. Significant negative correlations of albumin and positive correlations of AOPPs with, e.g., procalcitonin, D-dimers, lactate dehydrogenase, aspartate transaminase, and radiological scores of computed tomography (HRCT), were observed. The AOPPs/albumin ratio was found to be strongly correlated with D-dimers. We suggest that oxidized albumin could be involved in COVID-19 pathophysiology. Some possible clinical consequences of the modification of albumin are also discussed.

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Section: Discussionmentioning

confidence: 99%

Study of Albumin Oxidation in COVID-19 Pneumonia Patients: Possible Mechanisms and Consequences

Wybranowski

Napiórkowska

Bosek

et al. 2022

IJMS

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“…For example, COVID-19 has changed priorities in political agendas, and could have shifted agendas, placing IP-TFA as a non-urgent topic. However, it is important to highlight to policymakers that people with cardiovascular diseases are at a higher risk of severe symptoms and death from COVID-19 ( 10 ). Therefore, there is an urgent need for governments to implement cost-effective policy measures that tackle cardiovascular diseases such as the elimination of IP-TFA.…”

Section: Discussionmentioning

confidence: 99%

Evaluating progress and addressing actions to eliminate industrially produced trans-fatty acids in the Americas

Rincón-Gallardo¹,

Constantinou²,

Gorlick³

et al. 2022

Panam Salud Publica

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Objective. To evaluate the progress toward the 2023 target for the elimination of industrially produced trans-fatty acids (IP-TFA) in the Region of the Americas and to highlight the achievements of the four strategic lines of action from the Plan of Action for the Elimination of IP-TFA 2020-2025. Methods. A survey based on the World Health Organization (WHO) REPLACE package was used to collect data. The REPLACE package outlines six strategic action areas (Review, Promote, Legislate, Assess, Create, Enforce) to support the prompt, complete, and sustained elimination of IP-TFA from the food supply. Information was cross-checked and updated until December 2021. Results. Thirty countries in the Region responded to the survey between November 2019 and July 2020, an 85.7% response rate. As of December 2021, 21 additional indicators of the Regional Plan of Action were met, out of which, four consisted of new enactments of PAHO/WHO best practice policies for the elimination of IP-TFA by countries since baseline data was collected in 2018. This has resulted in a 63.0% increase in the proportion of the population in the Americas protected from consuming IP-TFA in 2021, compared to the baseline in 2018. Conclusion. Despite results showing progress in the Region, actions are needed to strengthen country capacity building and strategies to eliminate IP-TFA and fully achieve the 2023 goal.

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“…Nearly one-fourth of individuals hospitalized with COVID-19 have been diagnosed with cardiovascular complications, which have been reported to contribute to approximately 40% of all COVID-19-related deaths. 2 , 3 , 5 Several clinical trials have focused on the epidemiological and clinical characteristics of patients with COVID-19. However, there are limited data regarding the long-term consequences of COVID-19 after discharge from the hospital.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Clinical Consequences of Patients Hospitalized for COVID-19 Infection

Özcan

İnce

Güner

et al. 2022

Anatolian J Cardiol

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Background Coronavirus disease 2019, putatively caused by infection with severe acute respiratory coronavirus 2, often involves injury to multiple organs and there are limited data regarding the mid- to long-term consequences of coronavirus disease 2019 after discharge from the hospital. The study aimed to describe the mid- to long-term consequences of coronavirus disease 2019 in hospitalized patients after discharge. Methods This single-center, prospective study enrolled coronavirus disease 2019 patients who were discharged uneventfully from our center. All participants underwent face-to-face interviews by trained physicians and were asked to complete a series of questionnaires on third and sixth months’ follow-up visits. Results A total of 406 consecutive discharged coronavirus disease 2019 patients were enrolled in this study. Patients were divided into 3 groups according to World Health Organization classification as follows: World Health Organization-3 (n = 83); World Health Organization-4 (n = 291); and World Health Organization-5,6 (n = 32). Length of hospital stay was highly , significantly increased in the higher World Health Organization groups (World Health Organization-3 vs. World Health Organization-4, P < .0001; World Health Organization-3 vs. World Health Organization-5,6, P < .0001; World Health Organization-4 vs. World Health Organization-5,6, P < .0001), whereas the length of intensive care unit stay was highly , significantly increased only in World Health Organization-5,6 group compared to other groups (World Health Organization-3 vs. World Health Organization-5,6, P < .0001; World Health Organization-4 vs. World Health Organization-5,6, P < .0001). The most frequent complaints were chest pain (39%), and the frequency of complaints decreased during the 3-6 months follow-up period. Multiple logistic regression analysis indicated that age, coronary artery disease, fibrinogen, C-reactive protein, troponin I, D-dimer, use of steroid and/or low molecular weight heparin, and World Health Organization class were found to be independent predictors of ongoing cardiovascular symptoms. Conclusions The current data demonstrated that persistent symptoms were common after coronavirus disease 2019 among hospitalized patients. This should raise awareness among healthcare professionals regarding coronavirus disease 2019 aftercare.

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Cardiovascular Risk Factors and the Severity of COVID-19 Disease

Cited by 5 publications

References 18 publications

Study of Albumin Oxidation in COVID-19 Pneumonia Patients: Possible Mechanisms and Consequences

Study of Albumin Oxidation in COVID-19 Pneumonia Patients: Possible Mechanisms and Consequences

Evaluating progress and addressing actions to eliminate industrially produced trans-fatty acids in the Americas

Long-Term Clinical Consequences of Patients Hospitalized for COVID-19 Infection

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