Cardiovascular risk factors and migraine

Scher, Ann I.; Terwindt, G.M.; Picavet, H. Susan J.; Verschuren, W M Monique; Ferrari, Michel D.; Launer, Lenore J.

doi:10.1212/01.wnl.0000151857.43225.49

Cited by 427 publications

(453 citation statements)

References 38 publications

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“…The association between LRP1 and intracranial aneurysms has to our knowledge not been studied yet. Apart from the hypothesized direct causal associations, it is likely that there are common cardiovascular risk factors associated with both migraine and UIA, such as hypertension and smoking although we adjusted for these factors in our analyses (Scher et al., 2005; Vlak et al., 2013). More studies are needed to confirm our findings and to further investigate the underlying pathophysiology between the possible association between migraine and intracranial aneurysms.…”

Section: Discussionmentioning

confidence: 99%

Migraine prevalence in patients with unruptured intracranial aneurysms: A case–control study

et al. 2017

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ObjectivesMigraine is a suggested risk factor for aneurysmal subarachnoid hemorrhage (aSAH). An increased risk of aSAH in migraineurs may be explained by an increased prevalence of unruptured intracranial aneurysms (UIA). We performed a case–control study to compare lifetime migraine prevalence in patients with UIA, patients with a history of transient ischemic attact (TIA) or ischemic stroke and controls without a history of aSAH, TIA or ischemic stroke.Materials and MethodsPatients with UIA were recruited from two university hospitals. Data on patients with TIA/stroke were retrieved from a previous study. Partners of patients with UIA or TIA/stroke were included as controls. Migraine history was assessed via a telephone interview based on the International Classification of Headache Disorders, second edition criteria. We calculated odds ratios (OR) for migraine with univariable and multivariable logistic regression analyses, adjusted for age, sex, hypertension and smoking.ResultsWe included 172 patients with UIA, 221 patients with TIA or stroke, and 164 controls. In UIA patients, migraine prevalence was 24.4% compared with 14.6% in controls (UIA vs. controls; OR 1.9; 95% confidence interval [CI] 1.1–3.5) and 22.2% in TIA/stroke patients (UIA vs. TIA/stroke; OR 1.1; 95% CI 0.7–1.8). After adjustments, the OR for migraine in UIA patients versus controls were 1.7 (95% CI 1.0–3.1) and 0.9 (95% CI 0.5–1.0) versus TIA/stroke. Results were comparable for migraine with and without aura.ConclusionsMigraine prevalence is possibly increased in patients with UIA compared with controls and comparable with the prevalence in patients with TIA or stroke. Further studies are needed to confirm our findings and to investigate the underlying pathophysiology.

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Section: Discussionmentioning

confidence: 99%

Migraine prevalence in patients with unruptured intracranial aneurysms: A case–control study

et al. 2017

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“…The GEM population-based study reported that, compared to controls, migraineurs were more likely to smoke, less likely to drink alcohol and more likely to report a parental history of early myocardial infarction. Migraineurs with aura were more likely to have an unfavourable cholesterol profile, to have elevated blood pressure and to report a history of early onset coronary heart disease or stroke; female migraineurs with aura were more likely to be using oral contraceptives [22].…”

Section: Migraine and Strokementioning

confidence: 99%

Comorbid neuropathologies in migraine

et al. 2006

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The identification of comorbid disorders in migraineurs is important since it may impose therapeutic challenges and limit treatment options. Moreover, the study of comorbidity might lead to improve our knowledge about causes and consequences of migraine. Comorbid neuropathologies in migraine may involve mood disorders (depression, mania, anxiety, panic attacks), epilepsy, essential tremor, stroke, and white matter abnormalities. Particularly, a complex bidirectional relation exists between migraine and stroke, including migraine as a risk factor for cerebral ischemia, migraine caused by cerebral ischemia, migraine as a cause of stroke, migraine mimicking cerebral ischemia, migraine and cerebral ischemia sharing a common cause, and migraine associated with subclinical vascular brain lesions.

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“…Data from several studies suggest that migraine may be a risk factor for the development of stroke [3,4,[9][10][11][12] and MA may be an important risk factor for stroke in women [12,13]. The mechanisms that underlie these observations are unclear but a reasonable hypothesis could include the presence of shared risk factors as a possible cause.…”

Section: Discussionmentioning

confidence: 99%

“…There appears to be a clear correlation between migraine and stroke or other cardiovascular events in rare genetic conditions such as cerebral autosomal dominant arteriopathy with subcortical infarctions and leukoencephalopathy (CADASIL), mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) and the familial dyslipoproteinaemias [2]. Association between the common forms of migraine, stroke and other vascular risk factors has been shown in several large population-based studies [3,4]. An increase in vascular events in parents and grandparents of children with migraine compared to control subjects has been documented previously [5].…”

Section: Introductionmentioning

confidence: 99%

Clinic–based study of family history of vascular risk factors and migraine

et al. 2005

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The objective was to evaluate the presence of a positive family history (FH) of vascular risk factors between patients with migraine with aura (MA) and migraine without aura (MO), and in chronic migraine (CM) compared to other headache types. As migraine patients are typically too young to have developed vascular events, studying older relatives of migraine patients may be a practical means of evaluating associations between vascular risk factors and migraine. A cross-sectional study of a clinicbased sample of adults with migraine headache was carried out at the University of Utah. Predictor variables comprised first or second degree relatives with stroke, hypertension, diabetes or hypercholesterolaemia. Outcome measures comprised diagnosis of MA, MO or CM according to the revised International Headache Society criteria. There was no significant difference in FH of vascular risk factors in MA compared to MO (adjusted OR 1.04, 95% CI 0.61-1.78). CM was associated with a decreased risk of FH of stroke (OR=0.11, p=0.036). There was no significant difference in FH of vascular risk factors in MA patients compared to MO. CM patients were more likely to have a negative FH of stroke compared to other headache types, suggesting that CM is likely a neuronal disease rather than a vascular one.

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Cardiovascular risk factors and migraine

Abstract: Migraineurs, particularly with aura, have a higher cardiovascular risk profile than individuals without migraine.

Cited by 427 publications

References 38 publications

Migraine prevalence in patients with unruptured intracranial aneurysms: A case–control study

Migraine prevalence in patients with unruptured intracranial aneurysms: A case–control study

Comorbid neuropathologies in migraine

Clinic–based study of family history of vascular risk factors and migraine

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