Cardiovascular risk factors and cardiovascular disease in patients with type 1 diabetes and end-stage renal disease candidates for kidney-pancreas transplantation: Trends from 1999 to 2017

Ruiz, Sabina; Amor, Antonio J.; Pané, Adriana; Molina‐Andújar, Alícia; Ventura‐Aguiar, Pedro; Ferrer-Fàbrega, Joana; Esmatjes, Enric

doi:10.1016/j.diabres.2020.108135

Cited by 11 publications

(13 citation statements)

References 33 publications

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“…They are not only common in type 2 diabetes but they also exist in type 1 diabetes. 25 This makes it a significant burden of morbidity and mortality.…”

Section: Discussionmentioning

confidence: 99%

Cardiometabolic profile of type 2 diabetic subjects in Libreville

Bengone¹,

Nikiema-Ndong²,

Nsame³

et al. 2021

IJCBR

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Type 2 diabetes is the chronic metabolic disease associated with cardiovascular, renal and neurological complications, responsible for morbidity and mortality. In addition, the incidence of cardiovascular disease was 10.3 out of 1000 type 2 diabetics per year in low-income countries like Gabon. Thus, this work was setup to determine the cardiometabolic profile of type 2 diabetic subjects in Libreville.

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“…They are not only common in type 2 diabetes but they also exist in type 1 diabetes. 25 This makes it a significant burden of morbidity and mortality.…”

Section: Discussionmentioning

confidence: 99%

Cardiometabolic profile of type 2 diabetic subjects in Libreville

Bengone¹,

Nikiema-Ndong²,

Nsame³

et al. 2021

IJCBR

View full text Add to dashboard Cite

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“…Ruiz and colleagues examined trends in cardiovascular risk factors and cardiovascular disease (CVD) prevalence in patients with type 1 diabetes (T1DM) and end-stage renal disease (ESRD) in simultaneous pancreas-kidney (SPK) transplant candidates during 1999 to 2017 (n = 360 [64.4% men, age 38.9 ± 7.1 years]). 18 Cardiovascular risk factors included low-density lipoprotein (LDL)-cholesterol, statin use, blood pressure, current smokers, intensive insulin therapy, and T1DM duration before RRT. The study showed that patients with T1DM and ESRD had an increased risk for fatal CVD.…”

Section: Cardiovascular Risk Factorsmentioning

confidence: 99%

“…The increasing age of SPK transplant recipients highlights the importance of optimizing cardiovascular risk factors in this group. 18 Mean LDL-cholesterol decreased significantly (99.8 ± 35 mg/dL, P < .001), and use of highintensity statins (0% [1999][2000][2001][2002] to 29.5% [2015][2016][2017], P = .032) increased over the study period. Systolic blood pressure (SBP) decreased (138.8 ± 27.6 to 125.1 ± 27.9 mm Hg, P = .001).…”

Section: Cardiovascular Risk Factorsmentioning

confidence: 99%

“…Selected Articles in the Fields of Pancreas, Intestine, and Kidney Transplantations. Analysis of patients who had a kidney transplant or are on dialysis with COVID-19 from an extensive European database (ERACODA database) revealed that the 28-day mortality risk was 21.3% in kidney transplant recipients and 25.0% in dialysis patients.Pancreas transplantation• Risk factors: Ruiz et al18 A retrospective study of SPK candidates from 1999 to 2017, reviewing trends in cardiovascular risk factors and CVD prevalence.Over time, control of candidates' cardiovascular risk factors improved, and CVD prevalence decreased while simultaneously DM duration before RRT initiation increased.…”

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confidence: 99%

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Abdominal Organ Transplantation: Noteworthy Literature in 2020

Wang

Fagelman

Sakai

2021

Semin Cardiothorac Vasc Anesth

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In 2020, we identified and screened over 490 peer-reviewed publications on pancreatic transplantation, over 500 on intestinal transplantation, and over 5000 on kidney transplantation. The liver transplantation section specially focused on clinical trials and systematic reviews published in 2020 and featured selected articles. This review highlights noteworthy literature pertinent to anesthesiologists and critical care physicians caring for patients undergoing abdominal organ transplantation. We explore a wide range of topics, including COVID-19 and organ transplantation, risk factors and outcomes, pain management, artificial intelligence, robotic donor surgery, and machine perfusion.

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“…T1D patients are at increased risk of cardiovascular disease (CVD) due to both the adverse effects of hyperglycemia and the coexistence of other additional risk factors, including hypertension and dyslipidemia ( 5 ). In addition to the main CVD risk factors, additional, non-classical risk factors are thought to affect the prevalence of coronary artery disease (CAD).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency as a Predictor of a High Prevalence of Coronary Artery Disease in Pancreas Transplant Candidates With Type 1 Diabetes

et al. 2021

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IntroductionPancreas transplantation is a high-risk procedure in terms of cardiovascular complications. Therefore, identification of all cardiovascular risk factors is crucial to prevent cardiovascular complications after pancreas transplantation. Vitamin D deficiency (VDD) appears to be a potential risk factor for coronary artery disease.ObjectiveTo determine the prevalence of VDD in pancreas transplant candidates, and further to examine the relationship between vitamin D and the prevalence of coronary artery disease and lipid profile parameters.Materials and MethodsThis is a prospective cross-sectional study. We enrolled consecutive patients with type 1 diabetes eligible for simultaneous pancreas-kidney transplantation or pancreas transplant alone. The laboratory tests included HbA1c, lipid profile, creatinine, and total 25-hydroxyvitamin D (25(OH)D). The diagnosis of coronary artery disease was based on coronary angiography.ResultsThe study population included 48 patients. VDD was revealed in 48% of patients and coronary artery disease in 35% of patients. The mean concentration of vitamin D in the entire cohort was 21.3 ± 9.48 ng/ml. The median value of 25(OH)D in patients with coronary artery disease was significantly lower than in patients without coronary artery disease (18.5 (11.6–21.5) vs. 24.8 (18.4–31.8) ng/ml, p = 0.018). There was a significant relationship between VDD and coronary artery disease (OR = 4.36; 95% confidence interval (CI): 1.22–15.64, p = 0.034). A patient’s odds of having coronary artery disease while having a sufficient level of vitamin D was 4.36 times lower than if the patient had VDD. There was a significant relationship between VDD and hypertension (OR = 5.91; 95% CI: 1.12–31.20, p = 0.039) and hemodialysis (OR = 4.25; 95% CI: 1.25–14.5, p = 0.023). There was no significant correlation between 25(OH)D and lipid profile.ConclusionsVDD is highly prevalent in pancreas transplant candidates with type 1 diabetes. There is a significant relationship between VDD and increased prevalence of coronary disease. The lack of any significant association between serum vitamin D and lipid profile suggests that the relationship between vitamin D and coronary artery disease results from other causes.

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Cardiovascular risk factors and cardiovascular disease in patients with type 1 diabetes and end-stage renal disease candidates for kidney-pancreas transplantation: Trends from 1999 to 2017

Cited by 11 publications

References 33 publications

Cardiometabolic profile of type 2 diabetic subjects in Libreville

Cardiometabolic profile of type 2 diabetic subjects in Libreville

Abdominal Organ Transplantation: Noteworthy Literature in 2020

Vitamin D Deficiency as a Predictor of a High Prevalence of Coronary Artery Disease in Pancreas Transplant Candidates With Type 1 Diabetes

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