Cardiovascular risk factors among adult patients with haemophilia

Camelo, Ricardo Mesquita; Caram‐Deelder, Camila; Duarte, Beatriz Paschoal; Moura, M.C.B.; Costa, Neuza Cavalcanti de Moraes; Costa, Iris Maciel; Roncal, C.G.P.; Vanderlei, Ana Maria; Guimaraes, TMR; Gouw, Samantha C.; Rezende, Suely Meireles; Bom, J. van der

doi:10.1007/s12185-021-03104-y

Cited by 6 publications

(6 citation statements)

References 35 publications

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“…The ARCHER study, which included the largest Canadian cohort of hemophiliacs, confirmed the previous results [ 18 ]. There is only one study reporting HTN in South-American hemophiliacs [ 19 ]. It showed that the prevalence of HTN is higher in hemophiliacs than it is in the general population of Pernambuco and Brazil.…”

Section: Hypertensionmentioning

confidence: 99%

“…These results are valuable because unlike other studies that relied only on the history of gross hematuria, this study also included screening for asymptomatic hematuria by urinalysis/microscopy. Similarly, in a cohort of 82 hemophiliacs, only one case of CKD was identified [ 19 ].…”

Section: Hypertensionmentioning

confidence: 99%

“…The prevalence of diabetes in hemophiliacs varies widely across studies, from a lower prevalence compared to the general population [ 58 ] to a similar [ 30 ] or a higher one [ 65 ]. The prevalence of it was 9.2% in Asians [ 21 ], 6.1% in Europeans [ 30 ], 10.5% in Canadians [ 18 ] and 16% in Brazilians [ 19 ]. One study found that one in four hemophiliacs had hyperglycemia [ 67 ].…”

Section: Hypertensionmentioning

confidence: 99%

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Cardiovascular Risk Factors in Patients with Congenital Hemophilia: A Focus on Hypertension

et al. 2022

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Aging hemophiliacs face cardiovascular disease. Lots of evidence has been gathered that hemophiliacs have a more unfavorable cardiovascular profile than the general population does, especially due to the increased prevalence of hypertension (HTN). Among the existing scattered evidence, our study provides the most comprehensive and systematized analysis of the determinants of HTN in hemophiliacs. We discussed the contribution to the HTN substrate of hemophilia-specific factors, such as type, severity and the presence of inhibitors. The complex mechanism of kidney dysfunction in relation to hematuria and viral infections was meticulously addressed. Furthermore, we highlighted the new pathogenic concepts of endothelial dysfunction and the association between HTN and hemophilic arthropathy. The clustering of cardiovascular risk factors is common in hemophiliacs, and it enhances the negative vascular effect of HTN and aggravates HTN. It usually leads to an increased risk for coronary and cerebrovascular events. Our work provides reliable evidence to guide and improve the management of HTN in hemophiliacs.

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Section: Hypertensionmentioning

confidence: 99%

Section: Hypertensionmentioning

confidence: 99%

Section: Hypertensionmentioning

confidence: 99%

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Cardiovascular Risk Factors in Patients with Congenital Hemophilia: A Focus on Hypertension

et al. 2022

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“…Thus, considering that cardiovascular mortality is lower in hemophiliacs compared to the general population, but the amount of coronary artery atherosclerosis is similar, a possible explanation was initially sought in the direction of the prevalence of cardiovascular risk factors. Nonetheless, both older [36] and newer studies [37][38][39][40][41][42] showed that the prevalence of cardiovascular risk factors is as least as high in hemophiliacs as in the general population, if not higher.…”

Section: Cardiovascular Risk Factors and Atherosclerosis In Patients With Hemophiliamentioning

confidence: 99%

Current Therapeutic Approach to Acute Myocardial Infarction in Patients with Congenital Hemophilia

Bădescu

Ciocoiu

Rezuş

et al. 2021

Life

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Advances in the treatment of hemophilia have made the life expectancy of hemophiliacs similar to that of the general population. Physicians have begun to face age-related diseases not previously encountered in individuals with hemophilia. Treatment of acute myocardial infarction (AMI) is particularly challenging because the therapeutic strategies influence both the patient’s thrombotic and hemorrhagic risk. As progress has been made in the treatment of AMI over the last decade, we performed an in-depth analysis of the available literature, highlighting the latest advances in the therapy of AMI in hemophiliacs. It is generally accepted that after the optimal substitution therapy has been provided, patients with hemophilia should be treated in the same way as those in the general population. New-generation stents that allow short dual antiplatelet therapy and potent P2Y12 receptor inhibitors have begun to be successfully used. At a time when specific recommendations and relevant data are scarce, our study provides up-to-date information to physicians involved in the treatment of AMI in hemophiliacs.

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“…Such findings suggest that the avoidance of exercise may place people with hemophilia at increased risk of osteoarthrosis and of cardiovascular events [19,20]. Indeed, a recent study showed that PWH had a higher prevalence of blood hypertension compared to the general population in Brazil, and about two-fifths have a high risk of developing a cardiovascular event in the following 10 years [21]. Obesity and hypertension were frequent in a group of 48 PWH with a mean age of 21 ± 9 years, especially in those with arthropathy [22].…”

Section: Introductionmentioning

confidence: 99%

Promoting Sports Practice in Persons with Hemophilia: A Survey of Clinicians’ Perspective

Lassandro

Accettura

Giordano

2021

IJERPH

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Historically, people with hemophilia have been warned to avoid physical activities as a possible cause of bleeding; however, currently, sport is considered necessary, especially in the developmental age, for providing a good quality of life. A survey was proposed to a group of hematologists and sports physicians working in Puglia, Italy, to explore their approach to physical activities for their patients with hemophilia and to obtain suggestions about possible interventions to promote the access of patients to sports. The survey was answered by 6 hematologists and 15 sports physicians. In total, 71% (about six patients/year/physician) of patients with hemophilia seen by sports physicians asked for counseling about sports, and 67% (about five patients/year/physician) actually practiced sports. On the other hand, only 31% (about 16 patients/year/hematologist) of patients asked hematologists questions on sports, and only 16% (about seven patients/year/hematologist) of patients with hemophilia and that were followed-up by hematologists practiced sports. The sports most often recommended to patients with hemophilia by physicians included swimming, athletics, tennis, running and gymnastics. According to hematologists, physical activity was very efficient in improving the quality of life of patients; stability of joints; their psychological, social and musculoskeletal wellbeing; and in reducing the risk of bleedings. On the other hand, physical activity was considered less important in all these areas by sport physicians. In conclusion, answers to this survey suggested that sports could be promoted among hemophilic patients by increasing the sports physicians’ knowledge about hemophilia and their special role in this area. In addition, interviewed clinicians were of the opinion that increased awareness of specific guidelines and clinical practice protocols among both hematologists and sports physicians could be beneficial. Finally, answers suggested that access to fitness certification should be facilitated.

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Cardiovascular risk factors among adult patients with haemophilia

Cited by 6 publications

References 35 publications

Cardiovascular Risk Factors in Patients with Congenital Hemophilia: A Focus on Hypertension

Cardiovascular Risk Factors in Patients with Congenital Hemophilia: A Focus on Hypertension

Current Therapeutic Approach to Acute Myocardial Infarction in Patients with Congenital Hemophilia

Promoting Sports Practice in Persons with Hemophilia: A Survey of Clinicians’ Perspective

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