Cardiovascular Risk Factor Disparities in Adult Survivors of Childhood Cancer Compared With the General Population

Noyd, David H.; Liu, Qi; Yasui, Yutaka; Chow, Eric J.; Bhatia, Smita; Nathan, Paul C.; Landstrom, Andrew P.; Tonorezos, Emily S.; Casillas, Jacqueline; Berkman, Amy M.; Ness, Kirsten K.; Mulrooney, Daniel A.; Leisenring, Wendy M.; Howell, Carrie R.; Shoag, Jamie; Kirchhoff, Anne C.; Howell, Rebecca M.; Gibson, Todd M.; Zullig, Leah L.; Armstrong, Gregory T.; Oeffinger, Kevin C.

doi:10.1016/j.jaccao.2023.01.011

Cited by 6 publications

(3 citation statements)

References 45 publications

(55 reference statements)

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“…Intervention trials and continued observational work using large cohort and population-based data in survivors are necessary to determine the effectiveness of survivor-specific treatment. With recent work identifying racial disparities in the burden of CMRFs, independent of sociodemographic and treatment-related factors, 131 future studies must include diverse populations and capitalize on the use of available genetic and epigenetic data to optimize risk assessment and understand therapeutic response.…”

Section: Discussionmentioning

confidence: 99%

Modifiable Cardiometabolic Risk Factors in Survivors of Childhood Cancer

Hammoud,

Mulrooney,

Rhea

et al. 2024

JACC: CardioOncology

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Section: Discussionmentioning

confidence: 99%

Modifiable Cardiometabolic Risk Factors in Survivors of Childhood Cancer

Hammoud,

Mulrooney,

Rhea

et al. 2024

JACC: CardioOncology

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“…In this issue of JACC: CardioOncology , a study reported by Noyd et al 9 addresses this gap in the literature by investigating whether disparities in CVRFs by race/ethnicity are similar among childhood cancer survivors compared with the general population. To achieve this aim, the investigators leveraged 3 specific datasets: the retrospective CCSS (Childhood Cancer Survivor Study) cohort, which served as the population of interest, in addition to the CCSS sibling cohort and data from NHANES (National Health and Nutrition Examination Survey), which both served as the “general population” comparator cohorts.…”

mentioning

confidence: 99%

“…As a minimum, these findings should serve to catalyze the development and implementation of equitable survivorship-focused care programs nationally. 10 As Noyd et al 9 note, childhood cancer survivors, despite sharing similar oncological diagnoses, represent an ethnically and sociodemographically diverse group. As such, there is no one-size-fits-all model in how such services are designed and delivered.…”

mentioning

confidence: 99%

Cardiovascular Health Equity for Survivors of Childhood Cancer

Graham,

Sounderajah,

Johnson

2023

JACC: CardioOncology

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Feasibility of telehealth exercise and nicotinamide riboside supplementation in survivors of childhood cancer at risk for diabetes: A pilot randomized controlled trial

Bhandari,

Lukas,

Lee

et al. 2024

Pediatric Blood & Cancer

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BackgroundChildhood cancer survivors (CCS) have a 50% higher risk of diabetes mellitus (DM) compared with the general population. Interventions in survivors with prediabetes (fasting glucose 100‐125 mg/dL or hemoglobin A1c 5.7%‐6.4%) may mitigate the development of DM and its attendant morbidity, but there is limited information on the feasibility of secondary prevention in this setting.MethodsThis 6‐week pilot feasibility 1:1 randomized controlled trial enrolled 20 CCS on a structured telehealth exercise program ± nicotinamide riboside (NR), a nicotinamide adenine dinucleotide precursor. Feasibility metrics were: (1) ≥50% of eligible CCS enrolled onto study; (2) ≥70% of participants completed baseline and end‐of‐study assessments; (3) ≥70% compliance with exercise and NR. Secondary endpoints included changes in biomarkers associated with glucose homeostasis and muscle health.ResultsMedian age (years) at cancer diagnosis was 16.5 (range, 1.5‐21.5) and 35.5 (range, 18.0‐67.0) at study enrollment. Enrollment rate was 87%, and 85% of participants completed baseline and end‐of‐study assessments. The mean percentage of exercise sessions completed was 86.6%; NR compliance was > 90%. There were no severe adverse events attributable to study interventions. Secondary endpoints were not significantly different between study arms at study completion. Myostatin decrease was observed in participants who completed a higher median number of exercise sessions and was associated with decreased intramuscular adipose tissue and increased lower extremity muscle cross‐sectional area.ConclusionsA telehealth exercise intervention ± NR supplementation was feasible in CCS with prediabetes. Future studies in larger cohorts may be needed to evaluate their beneficial effects on muscle health and DM risk among CCS.

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Cardiovascular Risk Factor Disparities in Adult Survivors of Childhood Cancer Compared With the General Population

Cited by 6 publications

References 45 publications

Modifiable Cardiometabolic Risk Factors in Survivors of Childhood Cancer

Modifiable Cardiometabolic Risk Factors in Survivors of Childhood Cancer

Cardiovascular Health Equity for Survivors of Childhood Cancer

Feasibility of telehealth exercise and nicotinamide riboside supplementation in survivors of childhood cancer at risk for diabetes: A pilot randomized controlled trial

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