Cardiovascular responses to high-fat and high-carbohydrate meals in young subjects

Abstract

We compared the cardiovascular, glucose, insulin, and catecholamine responses to high-fat (F) and high-carbohydrate (C) meals in healthy young subjects (mean age 23 yr, range 19-39). Cardiac output rose 30 min after C by 32% [95% confidence interval (CI) of the increase +0.32 to +1.64 l/min] and after F by 22% [95% CI +0.30 to +1.96 l/min; P = 0.03, analysis of variance (ANOVA)]. Superior mesenteric artery blood flow rose by 87% 15 min after C (95% CI +119 to +258 ml/min) and by 122% (95% CI +138 to +392 ml/min) 45 min after F, with significantly different patterns of response (interaction effect P less than 0.05, ANOVA). Calf blood flow fell and remained low for 60 min after F but only fell 15 min after C, with a return to fasting levels thereafter (interaction effect P less than 0.03, ANOVA). Thirty minutes postprandially the change of calf blood flow from baseline after C was significantly different than after F (95% CI of differences +0.1 to +2.04 ml.100 ml-1.min-1). Glucose, insulin, and norepinephrine levels increased more after C than after F. Thus there are different regional vascular responses to C and F despite similar cardiac output increases.

Comparative effects of glucose and water drinks on blood pressure and cardiac function in older subjects with and without postprandial hypotension

“…1993) and the postprandial increases in CO, stroke volume (SV), and HR may be less than in healthy young (Sidery et al. 1991), although the latter have not been a consistent observation (Grobety et al. 2015), whereas increases in splanchnic blood flow appear comparable (Trahair et al.…”

“…In healthy young individuals, there are postprandial increases in cardiac output (CO) and heart rate (HR) (Sidery et al. 1991; Waaler and Eriksen 1992), as well as vasoconstriction in skeletal muscle and peripheral vascular beds (Sidery et al. 1991), so there is little, if any, change in BP despite splanchnic blood pooling (Sidery et al.…”

“…1991; Waaler and Eriksen 1992), as well as vasoconstriction in skeletal muscle and peripheral vascular beds (Sidery et al. 1991), so there is little, if any, change in BP despite splanchnic blood pooling (Sidery et al. 1991; Waaler and Eriksen 1992).…”

“…1991), so there is little, if any, change in BP despite splanchnic blood pooling (Sidery et al. 1991; Waaler and Eriksen 1992). Accordingly, in healthy young subjects, meal ingestion is associated with increases in both cardiac and muscle sympathetic activity (Hayano et al.…”

Blood flow in non-muscle tissues and organs during exercise: Nature of splanchnic and ocular circulation

“…Food intake increases splanchnic blood flow, contrary to the effect of exercise; food intake instantly increases the flow in the CA and SMA. According to research, the flow in the CA rapidly peaked at a 38-60% increase from resting levels 6,30) , while that in the SMA increased 1.5-to 3.5-fold at 5-60 min after food ingestion 6,[31][32][33][34] . The effect was greatly affected by the content of the ingested food, such that a richer energy content produced a greater peak 34) , and either protein or fat intake delayed the peak but increased its value 32,33) .…”