Cardiovascular responses to arterial hypoxia in awake sinoaortic-denervated dogs.

Krasney, J. A.; Magno, Michael G.; Levitzky, Michael G.; Koehler, Raymond C.; Davies, D. G.

doi:10.1152/jappl.1973.35.5.733

Cited by 36 publications

(18 citation statements)

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“…It is known that altera tions in either PO2, PCO2, or blood pH can lead to changes in haemodynamics and, probably, drug responses [3,14,15]. From the results of the present study, it cannot be concluded with certainty whether the ob served changes in haemodynamics and in drug responses were due to the alterations in PO2, PCO2, blood pH, or their combination.…”

Section: Discussioncontrasting

confidence: 62%

“…This is not at great vari ance with findings in dogs [14,15]. It has been suggested that the pattern of cardiovas cular adjustments results from the composite interaction of several neurogenic mecha nisms that have been shown to contribute to circulatory support during hypoxia [14,15], In the present investigation, repeated dose-response tests to adrenaline or acetyl choline during normal ventilation and hy poventilation were carried out under the same conditions of urethane anaesthesia. It is therefore unlikely that the changes in drug responses observed during hypoventilation resulted from the anaesthetic administered.…”

Section: Discussionsupporting

confidence: 50%

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Effects of Hypoventilation on the Cardiovascular Responses of Rats to Adrenaline and Acetylcholine

Dai¹,

Wong²

1985

Pharmacology

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Blood pressure and pulse rate in reponse to administered adrenaline and acetylcholine during hypoventilation were studied in urethane-anaesthetized rats. Hypoventilation was induced by decreasing the stroke volume of artificial ventilation from 1 ml/100 g to 0.3 ml/l00 g. There was a significant rise in pulse rate accompanied by minimal changes in blood pressure during hypoventilation. The blood pressure and pulse rate in response to adrenaline were significantly reduced. The depressant effect of acetylcholine on pulse rate was intensified, but that on blood pressure was not significantly affected. These findings suggest that the compensatory cardiovascular reflexes may be impaired during hypoventilation.

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Section: Discussioncontrasting

confidence: 62%

Section: Discussionsupporting

confidence: 50%

Effects of Hypoventilation on the Cardiovascular Responses of Rats to Adrenaline and Acetylcholine

Dai¹,

Wong²

1985

Pharmacology

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“…5). Increase in heart rate and cardiac output as well as alterations of arterial and pulmonary artery pressures are in accordance with findings reported in the literature (10,12,21,37,42,45,48,49,68). Undulating variations in arterial blood pressure were seen during the hypoxic tolerance test and the period of adaptation to hypoxia prior to the beginning of flow measurements.…”

Section: Discussionsupporting

confidence: 91%

“…These potentially deleterious reactions are considered to be modulated by cardiac nerves. It has been suggested that parasympathetic activity is reduced during mild or moderate hypoxia (21,35,45,48,50,52,75). It is overruled by central vagal stimulation during severe hypoxia (4).…”

Section: Discussionmentioning

confidence: 99%

Studies on the regulation of myocardial blood flow in man II. Effects of acute arterial hypoxia

Heiß

Töpfer

Barmeyer

et al. 1978

Clinical Cardiology

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Summary:To determine whether adjustment of myocardial blood flow (MBF) , myocardial oxygen consumption (MVOl) and myocardial substrate uptake (MSU) to acute arterial hypoxia is influenced by training effects on the heart, 7 trained and 7 untrained healthy individuals were investigated. MBF (argon method), MV'Ol and MSU of glucose, lactate and free fatty acids were measured at rest during normoxia and two different stages of acute arterial hypoxia: a) 12.82 vol% Ol; b) 8.74 vol% Ol. Measurements were carried out during hemodynamic and respiratory steady state conditions.Myocardial flow and metabolism of athletes were significantly (p

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“…known as Mayer waves, and the hypertensive response ta elevated intradural pressure, similai to the Cushing response of the CNS'intact preparation, are the result of changes in nervous tissue perfusion (Kaminski et al, 1970;Meyer & Winter, 1970 Downing, 1972;Krasney et al, 1973Krasney et al, , 1977,'as well as increases in sympathetic activity (Dower, 1975;Gregor & Janig, 1977).…”

mentioning

confidence: 99%

Hypoxic responses of sympathetic preganglionic neurons in the acute spinal cat

Rohlicek¹,

Polosa²

1981

American Journal of Physiology-Heart and Circulatory Physiology

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The relation between arterial O2 tension (PaO2) and the firing rate of sympathetic preganglionic neurons (SPN) of the cervical sympathetic trunk was studied during graded isocapnic hypoxia and hyperoxia in unanesthetized acute C-1 spinal cats. In the PaO2 range between 40 and 400 Torr there was no relation between the two variables. Below 40 Torr firing rate increased as PaO2 decreased, reaching an average peak value of ten times control at a PaO2 of 20 Torr. Mean arterial blood pressure (MABP) was also independent of PaO2 between 40 and 400 Torr and increased by an average of 25% at PaO2 values below 40 Torr. Intravenous administration of hexamethonium or phentolamine abolished the MABP response but not the SPN response to hypoxia. Pentobarbital (5-60 mg/kg iv) did not modify the SPN response to hypoxia, although normoxic SPN background firing was considerably depressed. The excitatory effect of hypoxia seems independent of excitatory afferent input and appears to be a general property of SPN.

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Cardiovascular responses to arterial hypoxia in awake sinoaortic-denervated dogs.

Cited by 36 publications

References 0 publications

Effects of Hypoventilation on the Cardiovascular Responses of Rats to Adrenaline and Acetylcholine

Effects of Hypoventilation on the Cardiovascular Responses of Rats to Adrenaline and Acetylcholine

Studies on the regulation of myocardial blood flow in man II. Effects of acute arterial hypoxia

Hypoxic responses of sympathetic preganglionic neurons in the acute spinal cat

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