Cardiovascular, respiratory, and blood adjustments to hypoxia in the Japanese eel,Anguilla japonica

Chan, D

doi:10.1007/bf02264086

Cited by 18 publications

(3 citation statements)

References 39 publications

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“…The dashed line is the line of identity and the solid line is the line of best fit. 1, turbot, Scophthalmus maximus (Maxime et al, 2000); 2, Atlantic cod, Gadus morhua (Mckenzie et al, 2009); 3, spangled perch, Leiopotherapon unicolor (Gehrke and Fielder, 1988); 4, European eel, Anguilla anguilla (Le Moigne et al, 1986); 5, flounder, Platichthys flesus (Steffensen et al, 1982); 6, flounder, Paralichthys dentatus (Capossela et al, 2012); 7, pacu, Piaractus mesopotamicus (Rantin et al, 1998;Leite et al, 2007); 8, traira, Hoplias malabaricus (Sundin et al, 1999;Monteiro et al, 2013); 9, Triaraõ, Hoplias lacerdae (Rantin et al, 1992); 10, rainbow trout, Oncorhynchus mykiss (Ott et al, 1980;Perry and Gilmour, 1996); 11, Japanese eel, Anguilla japonica (Chan, 1986); 12, matrinxa, Brycon amazonicus (Monteiro et al, 2013); 13, piracatinga (catfish), Calophysus macropterus (Scott et al, 2017); 14, sharpsnout sea bream, Diplodus puntazzo (Cerezo and Garcia Garcia, 2004); 15, jeju, Hoplerythrinus unitaeniatus (Oliveira et al, 2004); 16, Mayan cichlid, Mayaheros uropthalmus (Burggren et al, 2019); 17, Atlantic killifish, Fundulus heteroclitus (Giacomin et al, 2019); 18, Nile tilapia, Oreochromic niloticus (Thomaz et al, 2009;Martins et al, 2011); 19, bowfin, Amia calva (Porteus et al, 2014); 20, striped catfish, Pangasianodon hypophthalmus (Lefevre et al, 2011); 21, Amazonian oscar, Astronotus ocellatus (Scott et al, 2008).…”

Section: Experimental Animalsmentioning

confidence: 99%

Relationships between the peak hypoxic ventilatory response and critical O2 tension in larval and adult zebrafish (Danio rerio)

Mandic

Pan

Gilmour

et al. 2020

Journal of Experimental Biology

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Fish increase ventilation during hypoxia, a reflex termed the hypoxic ventilatory response (HVR). The HVR is an effective mechanism to increase O 2 uptake, but at a high metabolic cost. Therefore, when hypoxia becomes severe enough, ventilation declines, as its benefit is diminished. The water oxygen partial pressure (Pw O2) at which this decline occurs is expected to be near the critical Pw O2 (P crit), the Pw O2 at which O 2 consumption begins to decline. Our results indicate that in zebrafish (Danio rerio), the relationship between peak HVR and P crit is dependent on developmental stage. Peak ventilation occurred at Pw O2 values higher than P crit in larvae, but at a Pw O2 significantly lower than P crit in adults. Larval zebrafish use cutaneous respiration to a greater extent than branchial respiration and the cost of sustaining the HVR may outweigh the benefit, whereas adult zebrafish, which rely on branchial respiration, may benefit from using HVR at Pw O2 below P crit .

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Section: Experimental Animalsmentioning

confidence: 99%

Relationships between the peak hypoxic ventilatory response and critical O2 tension in larval and adult zebrafish (Danio rerio)

Mandic

Pan

Gilmour

et al. 2020

Journal of Experimental Biology

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“…Relative tissue distribution of mRNA of carnitine palmitoyltransferase (CPT)TilϪ1 iso1 (A), CPTTilϪ1 iso2 (A), peroxisome proliferator-activated receptor (PPAR)Til␣ (B), and pyruvate dehydrogenase (PDH) kinase (PDK)TilϪ2 (C) genes in tissues from tilapia (means Ϯ SE, n ϭ 3). mRNA levels are normalized to elongation factor-1␣ (EF-1␣) mRNA expression, with the level in heart set to 1. Atlantic cod (Gadus morhua) (21), Japanese eel (Anguilla japonica) (10)] and may be related to each speciesЈ P crit and the depression of Ṁ O 2 . In fact, P crit matches the PO 2 at initiation of bradycardia (i.e., P crit of f H ) in two Hoplias spp.…”

Section: Cardiac Atp Demandmentioning

confidence: 99%

Effects of environmental hypoxia on cardiac energy metabolism and performance in tilapia

Speers‐Roesch

Sandblom

Lau

et al. 2010

American Journal of Physiology-Regulatory, Integrative and Comp

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Speers-Roesch B, Sandblom E, Lau GY, Farrell AP, Richards JG. Effects of environmental hypoxia on cardiac energy metabolism and performance in tilapia. Am J Physiol Regul Integr Comp Physiol 298: R104 -R119, 2010. First published October 28, 2009 doi:10.1152/ajpregu.00418.2009.-The ability of an animal to depress ATP turnover while maintaining metabolic energy balance is important for survival during hypoxia. In the present study, we investigated the responses of cardiac energy metabolism and performance in the hypoxia-tolerant tilapia (Oreochromis hybrid sp.) during exposure to environmental hypoxia. Exposure to graded hypoxia (Ն92% to 2.5% air saturation over 3.6 Ϯ 0.2 h) followed by exposure to 5% air saturation for 8 h caused a depression of whole animal oxygen consumption rate that was accompanied by parallel decreases in heart rate, cardiac output, and cardiac power output (CPO, analogous to ATP demand of the heart). These cardiac parameters remained depressed by 50 -60% compared with normoxic values throughout the 8-h exposure. During a 24-h exposure to 5% air saturation, cardiac ATP concentration was unchanged compared with normoxia and anaerobic glycolysis contributed to ATP supply as evidenced by considerable accumulation of lactate in the heart and plasma. Reductions in the provision of aerobic substrates were apparent from a large and rapid (in Ͻ1 h) decrease in plasma nonesterified fatty acids concentration and a modest decrease in activity of pyruvate dehydrogenase. Depression of cardiac ATP demand via bradycardia and an associated decrease in CPO appears to be an integral component of hypoxia-induced metabolic rate depression in tilapia and likely contributes to hypoxic survival. fish; cardiovascular function; adenosine 5Ј-triphosphate; lipid; pyruvate dehydrogenase DURING PERIODS OF LOW OXYGEN, hypoxia-tolerant animals undergo a profound, rapid, and reversible metabolic rate depression as shown by large decreases in oxygen consumption rate (Ṁ O 2 ) and heat production (44,54). This metabolic rate depression reflects a downregulation of cellular ATP turnover to a level that can be sustained by oxygen-independent ATP production. The ability to balance ATP demand with supply and thus maintain stable cellular ATP concentration ([ATP]) is a key response ensuring hypoxic survival in tolerant animals, including many species of fishes that regularly encounter environmental hypoxia (7).A major component of the hypoxia-induced depression of ATP turnover is a reduction of cellular ATP demand, including the regulated arrest of ion pumping and anabolic pathways such as protein synthesis (30,45,49). Metabolic control analyses demonstrate, however, that ATP turnover in both active and metabolically depressed organisms can be controlled both by regulating ATP demand as well as by modulation of metabolic pathways involved in ATP supply such as mitochondrial substrate oxidation (6, 49). Our knowledge is incomplete as to how processes of ATP demand and ATP supply respond during hypoxia exposure in order to achiev...

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“…If severe enough, acute hypoxia constrains blood oxygenation at the gills in fish, which may compromise tissue O 2 delivery and aerobic metabolism (Boutilier, 2001;Butler and Taylor, 1975;Chan, 1986;Holeton and Randall, 1967;Powell et al, 2000;Stecyk, 2017;Steffensen and Farrell, 1998). Most fish, however, are 'O 2 regulators', meaning that they adjust cardiorespiratory functions (cardiovascular and metabolic) to maintain a stable O 2 consumption rate (ṀO 2 , a proxy for aerobic metabolic rate) over a range of speciesspecific hypoxic Pw O2 values (Svendsen et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Cardiorespiratory adjustments to chronic environmental warming improve hypoxia tolerance in European perch (Perca fluviatilis)

Ekström

Sundell

Morgenroth

et al. 2021

Journal of Experimental Biology

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Aquatic hypoxia will become increasingly prevalent in the future due to eutrophication combined with climate warming. While short-term warming typically constrains fish hypoxia tolerance, many fishes cope with warming by adjusting physiological traits through thermal acclimation. Yet, little is known about how such adjustments affect tolerance to hypoxia.We examined European perch (Perca fluviatilis) from the Biotest enclosure (23°C, Biotest population), a unique ∼1 km2 ecosystem artificially warmed by cooling water from a nuclear power plant, and an adjacent reference site (16-18°C, Reference population). Specifically, we evaluated how acute and chronic warming affect routine oxygen consumption rate (MO2routine) and cardiovascular performance in acute hypoxia, alongside assessments of the thermal acclimation of the aerobic contribution to hypoxia tolerance (critical O2 tension for MO2routine; Pcrit) and absolute hypoxia tolerance (O2 tension at loss of equilibrium; PLOE).Chronic adjustments (possibly across lifetime or generations) alleviated energetic costs of warming in Biotest perch by depressing MO2routine and cardiac output, and by increasing blood O2 carrying capacity relative to reference perch acutely warmed to 23°C. These adjustments were associated with improved maintenance of cardiovascular function and MO2routine in hypoxia (i.e., reduced Pcrit). However, while Pcrit was only partially thermally compensated in Biotest perch, they had superior absolute hypoxia tolerance (i.e., lowest PLOE) relative to reference perch irrespective of temperature.We show that European perch can thermally adjust physiological traits to safeguard and even improve hypoxia tolerance during chronic environmental warming. This points to cautious optimism that eurythermal fish species may be resilient to the imposition of impaired hypoxia tolerance with climate warming.

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Cardiovascular, respiratory, and blood adjustments to hypoxia in the Japanese eel,Anguilla japonica

Cited by 18 publications

References 39 publications

Relationships between the peak hypoxic ventilatory response and critical O2 tension in larval and adult zebrafish (Danio rerio)

Relationships between the peak hypoxic ventilatory response and critical O2 tension in larval and adult zebrafish (Danio rerio)

Effects of environmental hypoxia on cardiac energy metabolism and performance in tilapia

Cardiorespiratory adjustments to chronic environmental warming improve hypoxia tolerance in European perch (Perca fluviatilis)

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