Cardiovascular remodeling and the peripheral serotonergic system

Ayme-Dietrich, Estelle; Aubertin-Kirch, Gaëlle; Maroteaux, Luc; Monassier, Laurent

doi:10.1016/j.acvd.2016.08.002

Cited by 48 publications

(39 citation statements)

References 59 publications

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“…On the other hand, Trp hydroxylase facilitates the metabolism of ~5% Trp to 5‐hydroxy Trp, which generates 5‐HT by decarboxylase. Plasma 5‐HT released from blood platelets has been demonstrated to play a major role in the human cardiovascular system (Ayme‐Dietrich, Aubertin‐Kirch, Maroteaux, & Monassier, ). In the present study, our findings supported that the plasma concentrations of Trp, Kyn and 5‐HT and the ratios of Kyn/Trp as well as Trp/5‐HT might serve as the biomarkers for monitoring the initiation and progression of cardiovascular events such as acute myocardial infarction.…”

Section: Resultsmentioning

confidence: 99%

Simultaneous determination of tryptophan, kynurenine, kynurenic acid, xanthurenic acid and 5‐hydroxytryptamine in human plasma by LC‐MS/MS and its application to acute myocardial infarction monitoring

Tong

Song

Yang

et al. 2017

Biomedical Chromatography

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Reliable methods for the determination of tryptophan and its metabolites are vital to the monitoring of biochemical states during the initiation and progression of cardiovascular disease. In the present study, a single-run liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of tryptophan (Trp) and its metabolites, including kynurenine (Kyn), kynurenic acid (KA), xanthurenic acid (XA) and 5-hydroxytryptamine (5-HT), in human plasma. The plasma samples were prepared using a protein precipitation approach, and the chromatographic separation was performed by gradient elution on a C column within a total analysis time of 3.5 min. The calibration ranges were 40-20,000 ng/mL for Trp, 4-2000 ng/mL for Kyn, 0.2-100 ng/mL for KA, 0.4-200 ng/mL for XA and 1-500 ng/mL for 5-HT, and the precision and accuracy were acceptable. The evaluation of recovery and internal standard-normalized matrix effect proved that the sample preparation approach was effective and the matrix effect could be negligible. The newly developed method was successfully applied to the analysis of plasma samples from healthy individuals and myocardial infarction patients. The findings suggested that the plasma concentrations of Trp, Kyn, 5-HT as well as the concentration ratios of Kyn/Trp and Trp/5-HT might serve as biomarkers for the monitoring of acute myocardial infarction.

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Section: Resultsmentioning

confidence: 99%

Simultaneous determination of tryptophan, kynurenine, kynurenic acid, xanthurenic acid and 5‐hydroxytryptamine in human plasma by LC‐MS/MS and its application to acute myocardial infarction monitoring

Tong

Song

Yang

et al. 2017

Biomedical Chromatography

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“…This, in turn, would result in an overexpression of 5-HT5A receptors as a compensatory mechanism to modulate the cardiac sympathetic neurotransmission in the diabetic state. Similarly, other studies have associated the cardiovascular damage and endothelial dysfunction present in diabetes with peripheral serotonergic alterations [20,21,24,[43][44][45], even changing other peripheral systems related with α-adrenergic, dopaminergic and histaminergic mechanisms [28,29].…”

Section: The Specific Role Of Cardiac Sympatho-inhibitory 5-ht5a Recementioning

confidence: 90%

Exclusive Peripheral Overexpression of 5-HT5A Receptors is Involved in 5‑HT‑Induced Cardiac Sympatho-Inhibition in Type 1 Diabetic Rats

García-Pedraza

Hernández-Abreu

Morán

et al. 2020

Preprint

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Abstract Background: In normoglycaemic pithed rats, cardiac sympathetic control is modulated by serotonin (5-hydroxytryptamine; 5‑HT), which inhibits the cardioaccelerator sympathetic outflow via the activation of 5-HT 1B , 5-HT 1D and 5-HT 5A receptors. Notwithstanding, type 1 diabetes impairs the functionality of the cardiac sympathetic innervation and leads to cardiovascular complications including cardiac autonomic neuropathy. On this basis, the present study investigated whether the influence of 5-HT on cardiac noradrenergic neurotransmission is altered in type 1 diabetic rats, by analysing the profile of the 5-HT receptors involved and their peripheral expression. Methods: Type 1 diabetes was induced in male Wistar rats with a single injection of streptozotocin (50 mg/kg, i.p.). Four weeks later, the rats were anaesthetized, pithed and prepared for producing tachycardic responses by either electrical preganglionic stimulation (C 7 ‑T 1 ) of the cardioaccelerator sympathetic outflow or i.v. bolus injections of exogenous noradrenaline. Immunohistochemistry analyses were performed to study the expression of 5‑HT 1B , 5-HT 1D and 5-HT 5A receptors in the stellate (sympathetic) ganglion obtained from normoglycaemic and diabetic rats. Results: The increases in heart rate evoked by both cardiac sympathetic stimulation and exogenous noradrenaline were not modified after saline in diabetic rats. Moreover, i.v. continuous infusions of 5‑HT induced a cardiac sympatho-inhibition that was mimicked by the 5‑HT 1/5A receptor agonist 5‑carboxamidotryptamine, but not by the agonists indorenate (5-HT 1A ), CP 93,129 (5‑HT 1B ), PNU 142633 (5-HT 1D ), or LY344864 (5‑HT 1F ) in the diabetic group. In contrast, the above agonists at 5-HT 1B , 5-HT 1D and 5-HT 1/5A receptors mimicked 5-HT-induced sympatho-inhibition in normoglycaemic rats. In diabetic animals, i.v. administration of SB 699551 (1 mg/kg; 5‑HT 5A receptor antagonist) abolished 5‑CT-induced cardiac sympatho-inhibition. Finally, the immunohistochemistry analysis in the stellate ganglion showed that, as compared to normoglycaemic rats, in diabetic rats (P<0.05): (i) the expression of 5-HT 1B receptors was slightly higher, whereas that of 5-HT 1D receptors was slightly lower; and (ii) there was a clear overexpression of 5-HT 5A receptors. Conclusions: Taken together, these results show the prominent role of the peripheral overexpression of prejunctional 5-HT 5A receptors in the inhibition of the cardiac sympathetic drive in type 1 diabetic rats. These findings may represent a new pharmacological strategy for the treatment of diabetes-related cardiac abnormalities.

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“…Co więcej, wydłużona faza rozkurczu serca zwiększa perfuzję w naczyniach wieńcowych, a ich odruchowy rozkurcz nasila przepływ we wszystkich warstwach mięśnia sercowego [6,10] (ryc. 1) [11].…”

Section: Rola Serotoniny W Układzie Sercowo-naczyniowymunclassified

“…Głównym punktem końcowym była ocena frakcji wyrzutowej mierzona przez rezonans magnetyczny serca. Piboserod wyraźnie podnosił frakcję wyrzutową lewej komory (+1,7%), szczególnie u pacjentów nieprzyjmujących beta-adrenolityków [11].…”

Section: Niewydolność Sercaunclassified

Związek układu serotoninergicznego i układu sercowo-naczyniowego

et al. 2018

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Serotonin plays an important role in regulating the cardiovascular system. Drugs widely used in the treatment of depression, migraine, Parkinson's disease or obesity affect the serotonergic system. The use of these compounds causes both acute and chronic effects, depending on the type of activated 5-HT receptor and its location. An acute cardiac response to 5-HT, known as Bezold-Jarisch reflex, leads to bradycardia and hypotension. The chronic contribution of serotonin may be associated with fibrosis and cardiac valve degeneration. This article analyses the impact of 5-HT receptors activation on the cardiovascular system and describes side effects of this activation and new therapies targeting this system.

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Cardiovascular remodeling and the peripheral serotonergic system

Cited by 48 publications

References 59 publications

Simultaneous determination of tryptophan, kynurenine, kynurenic acid, xanthurenic acid and 5‐hydroxytryptamine in human plasma by LC‐MS/MS and its application to acute myocardial infarction monitoring

Simultaneous determination of tryptophan, kynurenine, kynurenic acid, xanthurenic acid and 5‐hydroxytryptamine in human plasma by LC‐MS/MS and its application to acute myocardial infarction monitoring

Exclusive Peripheral Overexpression of 5-HT5A Receptors is Involved in 5‑HT‑Induced Cardiac Sympatho-Inhibition in Type 1 Diabetic Rats

Związek układu serotoninergicznego i układu sercowo-naczyniowego

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