Cardiovascular, psychiatric, and neurological phenomena seen in mad honey disease: A clinical case report

Shrestha, Tirtha Man; Nepal, Gaurav; Shing, Yow Ka; Shrestha, Laxmi

doi:10.1002/ccr3.1889

Cited by 7 publications

(8 citation statements)

References 13 publications

(15 reference statements)

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“…8 Gastrointestinal symptoms like nausea, vomiting, neurological symptoms like blurring of vision, ataxic gait, peripheral numbness, and psychiatric symptoms have also been reported from mad honey poisoning in Nepal. 9 Grayanotoxin levels can be measured in blood and urine. However, the facility to measure the toxin levels is not available in the many hospitals of Nepal including ours.…”

Section: Discussionmentioning

confidence: 99%

Wild honey poisoning: A case report from western Nepal

Paudel¹,

Pokhrel²,

Gaire

et al. 2022

Clinical Case Reports

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Wild (Mad) honey poisoning is due to ingestion of honey containing a toxin known as grayanotoxin, which is also known as rhodotoxin because it is derived from the nectar of a few rhododendron species primarily found in the mountainous region of Bhutan, India, Nepal, and Turkey. 1 Mad honey is used as an alternative medicine for hypertension, diabetes, flu, gastrointestinal disorders (peptic ulcer, gastritis, dyspepsia, indigestion, and bowel disorder), and arthritis, stimulating sex (dysfunction, impotence, enhancement, and performance), viral infections, and cold. 2 Mad honey can cause dramatic side effects such as nausea, vomiting, dizziness, sweating, impaired consciousness, and various cardiac side effects like bradycardia and hypotension. 3 Ingestion honey containing grayanotoxin can result in hypotension, bradycardia, and cardiac rhythm disorders (first-, second-, and third-degree AV block, asystole, and sinus bradycardia). 4,5 Here, we present a case of mad honey poisoning, which developed bradycardia, hypotension, and dizziness. | CASE REPORTA 55-year-old woman presented to the emergency department with complaints of sudden onset of dizziness and vomiting for 2 h. Further history revealed that the symptoms appeared after 45-60 min after ingestion of 10-15 ml of wild honey. There was no history of trauma, alcohol, or drugs. The patient was a known case of hypertension under treatment with Losartan 25 mg per orally once daily

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Section: Discussionmentioning

confidence: 99%

Wild honey poisoning: A case report from western Nepal

Paudel¹,

Pokhrel²,

Gaire

et al. 2022

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

“…Mad honey, which is found in various types of rhododendron plants in the Eastern Black Sea region of Turkey, has been used for many years by the locals to treat diabetes, gastroduodenal maladies, and sexual dysfunction [ 3 ]. However, excessive consumption of this product can cause toxicity [ 4 ]. After the ingestion of wild honey, side effects such as exhaustion, dizziness, sweating, nausea, and vomiting occur.…”

Section: Discussionmentioning

confidence: 99%

“…The toxic effects of honey can be dose-dependent, but the dose-response relationship was not evaluated conclusively; further research is indubitably warranted [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Mad Honey Poisoning Case Series Presenting With ECG Findings Including Atrioventricular Complete Block and Symptomatic Hypotension

Islamoğlu¹,

Dokur²,

Talibli³

et al. 2021

Cureus

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Plants belonging to the Ericaceae family, which grow endemically in some parts of the world, contain grayanotoxin, which causes fatal bradyarrhythmia and circulatory collapse. Mad honey, which comes from plants with grayanotoxin, has various uses, namely, as an aphrodisiac, as an alternative therapy for GI disorders such as peptic ulcer, dyspepsia, and gastritis, and as a treatment for hypertension. However, GI, neurological and cardiac side effects may arise from its ingestion due to the grayanotoxin contained by this type of honey. Cardiac rhythm disturbances, sinus bradycardia, and other life-threatening side effects can occur, especially atrioventricular (AV) block and nodal rhythms. In this article, we present five honey poisoning cases involving adults who were admitted to our ED. Notably, one of the patients was unresponsive to atropine, so a temporary pacemaker was inserted, after which the patient was moved to the coronary ICU. Meanwhile, the cardiac rhythm of the other cases returned to normal in the follow-up after atropine administration.

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“…A study with 150 positive individuals of COVID-19 showed 7% of death exhibited due to myocarditis with circulatory collapse, meanwhile, 33% myocarditis contributed towards the final severe outcome [ 72 ]. Honey is proved for its long-term cardiovascular benefits as well as short-term antiarrhythmic effects [ 73 ]. A decreased rate of cardiovascular disease is often associated with flavonoids for example anthocyanin and vitamins including niacin (B 3 ).…”

Section: Pharmacological Effects Of Honeymentioning

confidence: 99%

Prospects of honey in fighting against COVID-19: pharmacological insights and therapeutic promises

Hossain¹,

Hossain

Moni³

et al. 2020

Heliyon

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Honey and its compounds are drawing attention as an effective natural therapy because of its ability to attenuate acute inflammation through enhancing immune response. Several studies have proved its potential healing capability against numerous chronic diseases/conditions, including pulmonary disorders, cardiac disorders, diabetes, hypertension, autophagy dysfunction, bacterial, and fungal infections. More importantly, honey has proved its virucidal effect on several enveloped viruses such as HIV, influenza virus, herpes simplex, and varicella-zoster virus. Honey may be beneficial for patients with COVID-19 which is caused by an enveloped virus SARS-CoV-2 by boosting the host immune system, improving comorbid conditions, and antiviral activities. Moreover, a clinical trial of honey on COVID-19 patients is currently undergoing. In this review, we have tried to summarize the potential benefits of honey and its ingredients in the context of antimicrobial activities, some chronic diseases, and the host immune system. Thus, we have attempted to establish a relationship with honey for the treatment of COVID-19. This review will be helpful to reconsider the insights into the possible potential therapeutic effects of honey in the context of the COVID-19 pandemic. However, the effects of honey on SARS-CoV-2 replication and/or host immune system need to be further investigated by in vitro and in vivo studies.

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Cardiovascular, psychiatric, and neurological phenomena seen in mad honey disease: A clinical case report

Cited by 7 publications

References 13 publications

Wild honey poisoning: A case report from western Nepal

Wild honey poisoning: A case report from western Nepal

Mad Honey Poisoning Case Series Presenting With ECG Findings Including Atrioventricular Complete Block and Symptomatic Hypotension

Prospects of honey in fighting against COVID-19: pharmacological insights and therapeutic promises

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