2013 Help me understand this report
Cardiovascular Protective Effect of Diltiazem in a Rat Model of Acute Myocardial Infraction With and Without Exercise
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“…Most recently, we have shown that a brief period of exercise increased absorption, as well as clearance (CL) and volume of distribution (Vd) of diltiazem (DTZ) after subcutaneous (sc) injection in rats [35]. In addition, exercise can also enhance the cardiovascular protective effect of DTZ [36]. These effects are likely to be individual and therapy specific, and at the current levels of physical activity recommended, not likely to have a significant impact in routine clinical practice.…”
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confidence: 99%
“…Most recently, we have shown that a brief period of exercise increased absorption, as well as clearance (CL) and volume of distribution (Vd) of diltiazem (DTZ) after subcutaneous (sc) injection in rats [35]. In addition, exercise can also enhance the cardiovascular protective effect of DTZ [36]. These effects are likely to be individual and therapy specific, and at the current levels of physical activity recommended, not likely to have a significant impact in routine clinical practice.…”
mentioning
confidence: 99%
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