Cardiovascular Properties of Yangambin, a Lignan Isolated from Brazilian Plants

Tibiriçá, Eduardo

doi:10.1111/j.1527-3466.2001.tb00073.x

Cited by 18 publications

(14 citation statements)

References 70 publications

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“…Plant lignans have been reported to exert anti-PAF activity (Biftu & Stevenson, 1987;Shen & Hussaini, 1990;Tibirica, 2001). Flaxseed potentially inhibits several mechanisms associated with renal disease in lupus nephritis.…”

Section: Hepatoprotective Effectsmentioning

confidence: 99%

Plant and mammalian lignans: A review of source, intake, metabolism, intestinal bacteria and health

Landete

2012

Food Research International

214

167

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Section: Hepatoprotective Effectsmentioning

confidence: 99%

Plant and mammalian lignans: A review of source, intake, metabolism, intestinal bacteria and health

Landete

2012

Food Research International

214

167

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“…Studies have revealed that it is a specific PAF inhibitor which antagonizes competitively PAF binding to its receptor [22]. It displays beneficial actions against allergy and headache [23, 24] along with its cardioprotective role [25]. …”

Section: Organic Paf Inhibitorsmentioning

confidence: 99%

A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?

Papakonstantinou

Lаgopati

Tsilibary

et al. 2017

Bioinorganic Chemistry and Applications

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In this minireview, we refer to recent results as far as the Platelet Activating Factor (PAF) inhibitors are concerned. At first, results of organic compounds (natural and synthetic ones and specific and nonspecific) as inhibitors of PAF are reported. Emphasis is given on recent results about a new class of the so-called metal-based inhibitors of PAF. A small library of 30 metal complexes has been thus created; their anti-inflammatory activity has been further evaluated owing to their inhibitory effect against PAF in washed rabbit platelets (WRPs). In addition, emphasis has also been placed on the identification of preliminary structure-activity relationships for the different classes of metal-based inhibitors.

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“…Phytochemical and biological studies have identified potential antitumoural substances including some lignans [10]. These substances may display a variety of pharmacological properties including immunosuppressive [11], vasoactive [12], antioxidant [13], antiviral [14], anti-inflammatory [15] and antitumoural [16] actions. Lignans are an important class of secondary metabolites found in many plant species belonging to more than seventy families [17].…”

Section: Introductionmentioning

confidence: 99%

The Cytotoxic Effect and the Multidrug Resistance Reversing Action of Lignans fromPhyllanthus amarus

et al. 2006

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Multidrug resistance (MDR) constitutes the major obstacle to the successful treatment of cancer. In several cancer cells, MDR is thought to be mediated by the super-expression of P-glycoprotein (Pgp). Pgp extrudes drugs from the cells, therefore reducing their cytotoxicity, and its activity inhibition may reverse the MDR phenotype. The present study evaluated the possible cytotoxic effect and MDR reversing properties of the extract and compounds isolated from Phyllanthus amarus. To this purpose, two human leukaemia cell lines were employed: K-562 and its vincristine-resistant counterpart Lucena-1, a Pgp-overexpressing subline. We report here that Lucena-1 was significantly more resistant to the cytotoxicity of P. amarus derivatives: the hexane extract (HE, 100 microg/mL), the lignans-rich fraction (LRF, 100 microg/mL) and the lignans nirtetralin (NIRT, 43.2 microg/mL), niranthin (NIRA, 43 microg/mL) or phyllanthin (PHYLLA, 43 microg/mL) exerted cytotoxic effects on K-562 cells with 40.3, 66.0, 62.0, 61.0 or 24.1% of cell death, respectively. The cellular toxicity observed on Lucena-1 was 16.3, 40.4, 29.4, 30.2, or 24.8%, respectively. However, cell treatment with the lignan phyltetralin (PHYLT) up to 41.6 microg/mL had no cytotoxic action on either of the cell lines. P. amarus derivatives were also found to be effective in inhibiting Pgp activity as assessed by rhodamine accumulation in Lucena-1 cells, as were the classical Pgp inhibitors, cyclosporine A (160 nM), PSC-833 (2 microM) and verapamil (5 microM). The lignan NIRT produced the most potent inhibition (EC (50) = 29.4 microg/mL) followed by NIRA (44.3 microg/mL), LRF (49.1 microg/mL), PHYLT (99.4 microg/mL), PHYLLA and HE (> 100 microg/mL). Lucena-1 cells were more resistant to daunorubicin-induced cell death (LC (50) = 50 microM) than K562 cells (LC (50) = 4.95 microM). Of note, the P. amarus derivatives significantly potentiated 5 microM daunorubicin-induced cell death in Lucena-1 cells (P < 0.01) but not in K562 cells. After treatment only with P. amarus derivatives (100 microg/mL HE, 30 microg/mL LRF, 12.9 microg/mL NIRA, 43.2 microg/mL NIRT, 43 microg/mL PHYLLA or 41.6 microg/mL PHYLT), the Lucena-1 cellular viability was 83.7, 85.3, 101, 69.7, 75.6 or 88.7%, respectively, whereas the in the presence of daunorubincin, which was not cytotoxic PER SE, the cell viability decreased to 42.9, 42.2, 64.2, 35.4, 30.4 or 52.6%, respectively. Together, these results suggest a potential action of P. amarus derivatives as MDR reversing agents, mainly due to their ability to synergize with the action of conventional chemotherapeutics.

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Cardiovascular Properties of Yangambin, a Lignan Isolated from Brazilian Plants

Cited by 18 publications

References 70 publications

Plant and mammalian lignans: A review of source, intake, metabolism, intestinal bacteria and health

Plant and mammalian lignans: A review of source, intake, metabolism, intestinal bacteria and health

A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?

The Cytotoxic Effect and the Multidrug Resistance Reversing Action of Lignans fromPhyllanthus amarus

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