Cardiovascular outcomes of patients treated for non-Hodgkin lymphoma with first-line doxorubicin-based chemotherapy

Zduniak, Alexandra; Lévêque, Émilie; Perdrix, A.; Étancelin, Pascaline; Ménard, Anne‐Lise; Lenain, Pascal; Contentin, Nathalie; Pépin, Louis-Ferdinand; Leprêtre, Stéphane; Lemasle, Emilie; Lanic, Hélène; Stamatoullas‐Bastard, Aspasia; Kammoun-Quique, Leila; Tilly, Hervé; Bauer, Fabrice; Jardin, Fabrice; Camus, Vincent

doi:10.1080/10428194.2022.2123222

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…In the United States, research on disparities in common cancers with elevated cardiovascular risk, including lung, 66 , 67 , 68 colorectal, 69 , 70 , 71 , 72 bladder, 73 , 74 endometrial, 75 , 76 and hematologic malignancies, 77 , 78 , 79 , 80 , 81 is still underway. Understanding the shared risk factors between these cancers and CVDs, combined with recent treatment advancements, underscores the need to address social disparities in this space.…”

Section: Cardiovascular Risk In Higher Prevalence Cancers In the Usmentioning

confidence: 99%

Health Literacy, Individual and Community Engagement, and Cardiovascular Risks and Disparities

Taylor,

Hong,

Hahm

et al. 2024

JACC: CardioOncology

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Section: Cardiovascular Risk In Higher Prevalence Cancers In the Usmentioning

confidence: 99%

Health Literacy, Individual and Community Engagement, and Cardiovascular Risks and Disparities

Taylor,

Hong,

Hahm

et al. 2024

JACC: CardioOncology

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“…Ang II activates renal NOXA1/NOX1-dependent ROS, enhancing tubular ENaC expression and Na + reabsorption, leading to hypertension, another AF risk factor [38,39]. NOX1 and NOX4 levels were significantly increased in the myocardium, as well as in cardiomyocytes of neonates treated with doxorubicin [40], a drug that induces cardiovascular toxicity and can cause AF in mice [41] and humans [42].…”

Section: Sources Of Cardiac Rosmentioning

confidence: 99%

NADPH Oxidases and Oxidative Stress in the Pathogenesis of Atrial Fibrillation

Ramos-Mondragón,

Lozhkin,

Vendrov

et al. 2023

Antioxidants

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Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and its prevalence increases with age. The irregular and rapid contraction of the atria can lead to ineffective blood pumping, local blood stasis, blood clots, ischemic stroke, and heart failure. NADPH oxidases (NOX) and mitochondria are the main sources of reactive oxygen species in the heart, and dysregulated activation of NOX and mitochondrial dysfunction are associated with AF pathogenesis. NOX- and mitochondria-derived oxidative stress contribute to the onset of paroxysmal AF by inducing electrophysiological changes in atrial myocytes and structural remodeling in the atria. Because high atrial activity causes cardiac myocytes to expend extremely high energy to maintain excitation-contraction coupling during persistent AF, mitochondria, the primary energy source, undergo metabolic stress, affecting their morphology, Ca2+ handling, and ATP generation. In this review, we discuss the role of oxidative stress in activating AF-triggered activities, regulating intracellular Ca2+ handling, and functional and anatomical reentry mechanisms, all of which are associated with AF initiation, perpetuation, and progression. Changes in the extracellular matrix, inflammation, ion channel expression and function, myofibril structure, and mitochondrial function occur during the early transitional stages of AF, opening a window of opportunity to target NOX and mitochondria-derived oxidative stress using isoform-specific NOX inhibitors and mitochondrial ROS scavengers, as well as drugs that improve mitochondrial dynamics and metabolism to treat persistent AF and its transition to permanent AF.

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A real-world pharmacovigilance study investigating the toxicities of histone deacetylase inhibitors

Li,

Fu,

Wang

2024

Ann Hematol

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Cardiovascular outcomes of patients treated for non-Hodgkin lymphoma with first-line doxorubicin-based chemotherapy

Cited by 3 publications

References 28 publications

Health Literacy, Individual and Community Engagement, and Cardiovascular Risks and Disparities

Health Literacy, Individual and Community Engagement, and Cardiovascular Risks and Disparities

NADPH Oxidases and Oxidative Stress in the Pathogenesis of Atrial Fibrillation

A real-world pharmacovigilance study investigating the toxicities of histone deacetylase inhibitors

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