Cardiovascular outcomes and fracture risk after the discontinuation of preventative medications in older patients with complex health needs: a self-controlled case series analysis
Daniel Prieto-Alhambra,
Francesco Dernie,
Antonella Delmestri
et al.
Abstract:Objective To assess the effect of stopping statins, antihypertensives, and bisphosphonates on the risk of cardiovascular events and fractures in older patients with complex health needs (CHN). Methods Patients aged >65 years, registered in CPRD GOLD for ≥1 year before study start (01/01/2010) and with CHN (non-elective hospitalisation/s, frailty or polypharmacy) were selected. Self-controlled case series (SCCS) analyses were subsequently conducted among people who did not use the respective preventative tre… Show more
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