Cardiovascular Oncologic Emergencies

Shenoy, Sundeep; Shetty, Safal; Lankala, Shilpa; Anwer, Faiz; Yeager, Andrew M.; Adigopula, Sasikanth

doi:10.1159/000475491

Cited by 15 publications

(6 citation statements)

References 68 publications

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“…However, there is no evidencebased validation for any of these approaches that they are curative. 2 Since lymphomas are steroid-sensitive malignancies, the steroid therapy provided symptomatic relief in the present case. The present patient responded well to the standard chemotherapy for diffuse large B cell lymphoma.…”

Section: Figure 1 Mediastinal Lymphadenopathy In Magnetic Resonance Imentioning

confidence: 68%

“…Superior vena cava syndrome (SVCS) develops due to external mechanical pressure of superior vena cava (SVC) by a mass lesion or by an enlarged lymph node, tumor invasion of the vessel wall, or venous thrombosis resulting in intraluminal obstruction. 1,2 Despite symptomatic relief is the rule in treatment of the patients with SVCS 3 , cerebral edema may develop. 4 The underlying etiologic cause is malignancy in about 60-90% of SVCS cases.…”

Section: Introductionmentioning

confidence: 99%

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Superior Vena Cava Syndrome and Multiple Venous Thrombosis in a Patient with B Cell Lymphoma

Koçak

Aktaş

Erkuş

et al. 2018

amj

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Background: Superior vena cava syndrome (SVCS) develops due to external mechanical pressure of superior vena cava (SVC) by a mass lesion or by an enlarged lymph node, tumor invasion of the vessel wall, or venous thrombosis resulting in intraluminal obstruction. Approximately 3,9% of lymphomas are complicated with SVCS. This rate reaches to 7% in diffuse large B cell lymphoma. The objective of this article was to describe a case report of a young woman with a diffuse large B cell lymphoma, complicated with pericardial-pleural effusion and SVCS. Methods: A 25 year old woman referred to the Internal Medicine Clinic of Abant Izzet Baysal University Hospital with complaints of bloating in the neck and both arms. She had chest pain, dyspnea, cough, and epigastric discomfort for 10 days. A thoracic magnetic resonance imaging (MRI) test and pathological assessment were carried out. Results: A mediastinal mass 64x112x82 mm in size, displaced the heart and main mediastinal structures to posterior, was detected by thoracic magnetic resonance imaging (MRI) test. The result of the pathological assessment of the biopsy specimen revealed large B cell lymphoma, stained strongly and diffusely with CD20 and bcl-2. She was referred to the hematology unit and doing well after a chemotherapy. Conclusions: Diagnosis of SVCS requires high level of clinical suspicion, detailed and complete physical examination. Moreover, SVCS should be kept in mind in the differential diagnosis of patients presented with edema in the neck and upper extremities.

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Section: Figure 1 Mediastinal Lymphadenopathy In Magnetic Resonance Imentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Superior Vena Cava Syndrome and Multiple Venous Thrombosis in a Patient with B Cell Lymphoma

Koçak

Aktaş

Erkuş

et al. 2018

amj

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“…Pericardial radiation injury causes neovascularization that furthers micro-ischemia, fibrosis, and inflammation, leading to disrupted pericardial venous and lymphatic drainage and a chronic exudative pericardial effusion [69]. While some cancer patients may develop rapidly accumulating or large volume malignant effusions presenting with cardiac tamponade, this is more typical of metastatic involvement of the pericardium or direct local invasion of mediastinal and thoracic malignancies [74,75]. Chronic inflammation and fibrosis of the pericardium results in constrictive pericarditis and restrictive cardiomyopathy, disrupting ventricular hemodynamics through normalization of right ventricle (RV) and LV pressures, and RV encroachment on LV diastole with impaired filling and output, and loss of inspiratory negative thoracic pressure assisting in biventricular filling [72].…”

Section: Radiotherapy Cardiotoxicity and Cardiomyopathymentioning

confidence: 99%

Heart Failure and Malignancy: Implications of Chemotherapy and Radiation in the Pathogenesis of Cardiomyopathy in Cancer Treated Populations

Wengrofsky

Srinivasan

Aboushi

et al. 2020

JOCCT

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The field of Cardio-oncology is rapidly growing with significant advances in research leading to better understanding of the underlying pathogenesis with implications in the diagnosis and management of cancer-related cardiomyopathy. Parallel to advancement in cardio-oncology is an increased awareness of the incidence of congestive heart failure and cardiomyopathy associated with malignancy. While specific cardiotoxic profiles exist for certain chemotherapeutic agents, there is increasing evidence of unexpected cardiotoxic side effects of some therapeutic modalities, combination chemo- and radiotherapy with large analyses identifying a strong association between malignancy and Takotsubo cardiomyopathy. Takotsubo Cardiomyopathy, also known as “broken-heart” syndrome or stress cardiomyopathy, is characterized by transient and reversible, regional or global, myocardial dysfunction without inciting ischemic perfusion defect from obstructive coronary artery disease. While direct causative pathophysiologic mechanisms continue to be investigated, much of the postulated pathways center on the high emotional and physical burdens of cancer and the related emotional stress associated with the diagnosis of cancer as well as the corporal effects of anti-neoplastic therapies, radiation, and oncologic surgery. In this manuscript we review the most current data in this rapidly emerging field highlighting the epidemiology, the postulated pathogenetic mechanisms as well as the current guidelines by major societies addressing malignancy -associated heart failure and cardiomyopathy, a rather complex disease entity with high morbidity and mortality.

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“…L'hyperviscosité va en effet favoriser la stase et les thromboses. L'hémodilution peut se compliquer d'un tableau d'insuffisance cardiaque avec oedème aigu pulmonaire de surcharge [19].…”

Section: Diagnostic Anamnèse Et Cliniqueunclassified

Syndrome d’hyperviscosité : mise au point pour les réanimateurs

Valade

Lemiale

Mariotte

2018

Méd. Intensive Réa.

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Le syndrome d’hyperviscosité (SH) est une entité clinique composée de signes variables non spécifiques et dont le diagnostic repose sur un faisceau d’arguments contextuels, anamnestiques et clinicobiologiques. En dehors de la mesure de la viscosité plasmatique, l’examen le plus spécifique pour confirmer le diagnostic semble être le fond d’œil. L’incidence du SH est inconnue, mais il s’agit d’une complication rare d’un grand nombre de pathologies. La physiopathologie est en rapport avec une augmentation de la viscosité plasmatique ou avec une augmentation du nombre d’éléments figurés du sang et/ou une altération de la capacité de ces cellules à circuler dans le lit capillaire. Le SH relève toujours d’un traitement de la pathologie sous-jacente et d’un traitement symptomatique visant à diminuer la viscosité sanguine. Dans les formes les plus sévères, il peut être nécessaire de recourir à un traitement par aphérèse thérapeutique en urgence. Le pronostic dépend principalement de la pathologie sous-jacente.

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Cardiovascular Oncologic Emergencies

Cited by 15 publications

References 68 publications

Superior Vena Cava Syndrome and Multiple Venous Thrombosis in a Patient with B Cell Lymphoma

Superior Vena Cava Syndrome and Multiple Venous Thrombosis in a Patient with B Cell Lymphoma

Heart Failure and Malignancy: Implications of Chemotherapy and Radiation in the Pathogenesis of Cardiomyopathy in Cancer Treated Populations

Syndrome d’hyperviscosité : mise au point pour les réanimateurs

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