Cardiovascular mortality in a randomized trial of adjuvant radiation therapy versus surgery alone in primary breast cancer

Rutqvist, Lars Erik; Lax, Ingmar; Fornander, Tommy; Johansson, Hemming

doi:10.1016/0360-3016(92)90784-f

Cited by 378 publications

(134 citation statements)

References 30 publications

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“…81 For left-sided lesions, efforts should be made to minimize the amount of heart in tangential fields. [82][83][84] Whole breast radiation therapy is delivered using opposed tangential fields to a dose of 4,500 to 5,000 cGy at 180 to 200 cGy per fraction.…”

Section: Elements In the Technique Of Irradiationmentioning

confidence: 99%

Standard for Breast Conservation Therapy in the Management of Invasive Breast Carcinoma

Morrow

Strom

Bassett

et al. 2002

CA: A Cancer Journal for Clinicians

297

165

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Multidisciplinary guidelines for management of invasive breast carcinoma from the American College of Radiology, the American College of Surgeons, the College of American Pathology, and the Society of Surgical Oncology have been updated to reflect the continuing advances in the diagnosis and treatment of invasive breast cancer. The guidelines provide a framework for clinical decision‐making for patients with invasive breast carcinoma based on review of relevant literature and include information on patient selection and evaluation, technical aspects of surgical treatment, techniques of irradiation, and follow‐up care.

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Section: Elements In the Technique Of Irradiationmentioning

confidence: 99%

Standard for Breast Conservation Therapy in the Management of Invasive Breast Carcinoma

Morrow

Strom

Bassett

et al. 2002

CA: A Cancer Journal for Clinicians

297

165

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“…The risk of RIHD is related to the total radiation dose and the irradiated volume (Steinherz and Yahalom, 1993;Gyenes et al, 1994). There are reports that left-sided chest irradiation causes more cardiotoxicity than right-sided irradiation (Rutqvist et al, 1992).…”

mentioning

confidence: 99%

Cardiotoxicity from intensive chemotherapy combined with radiotherapy in breast cancer

Graaf

Dolsma²,

Willemse³

et al. 1997

Br J Cancer

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Summary Cardiac function was evaluated in 86 breast cancer patients after standard chemotherapy, followed by ablative chemotherapy and chest irradiation. One patient died of subacute heart failure 3 months after ablative chemotherapy. At a minimum of 1 year's follow-up (range 1-11 years) left vertricular ejection fraction (LVEF) was marginally abnormal in 4 of 27 disease-free survivors. One exceptional patient who received two transplantations is alive, with serious heart failure occurring after the second ablative chemotherapy. Including this patient, the percentage of patients free of clinical and subclinical cardiac dysfunction at 7 years is 78% (95% Cl 61-95%). After ablative chemotherapy, cardiotoxicity was rarely life-threatening. The impact of subclinical cardiotoxicity in the long term is not clear and needs continued evaluation.

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“…A randomized trial from Stockholm, involving 960 women treated with pre-or postoperative radiotherapy compared with mastectomy alone, reported that patients who received the highest doses to the myocardium experienced increased risks of death from ischemic heart disease (relative hazard ratio 3.2, p < 0.05) (level II evidence). 100,101 Hojris and colleagues 102 reported no…”

Section: Cardiac Toxicitiesmentioning

confidence: 99%

Clinical practice guidelines for the care and treatment of breast cancer: 16. Locoregional post-mastectomy radiotherapy

Truong

Olivotto²,

Whelan³

et al. 2004

Canadian Medical Association Journal

160

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Cardiovascular mortality in a randomized trial of adjuvant radiation therapy versus surgery alone in primary breast cancer

Cited by 378 publications

References 30 publications

Standard for Breast Conservation Therapy in the Management of Invasive Breast Carcinoma

Standard for Breast Conservation Therapy in the Management of Invasive Breast Carcinoma

Cardiotoxicity from intensive chemotherapy combined with radiotherapy in breast cancer

Clinical practice guidelines for the care and treatment of breast cancer: 16. Locoregional post-mastectomy radiotherapy

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