Cardiovascular Manifestations of Severe Scorpion Sting

Gueron, M; Yaron, Rema

doi:10.1378/chest.57.2.156

Cited by 167 publications

(58 citation statements)

References 13 publications

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“…They usually manifest into different grades, benign, moderate and severe to fatal (Goyffon, 2002). The scorpion induced hemodynamic disorders usually manifests by a rapid and transient hypertensive phase, which is followed by a more lasting hypotensive one (Gueron and Yaron, 1970;Tarasiuk et al, 1998). The mechanism of cardiovascular anomalies had been in the long run debated.…”

Section: Introductionmentioning

confidence: 99%

“…The hypo-oxygenic statute consequent to pulmonary edema could also contribute in the observed alterations. Other authors suggested a direct effect of scorpion toxins on the electrophysiological statute of cardiomyocytes (Gueron and Yaron, 1970). Because of its important worldwide frequency, reaching above one million stung human each year (Chippaux and Goyffon, 2008), various preventive and curative anti-scorpionism strategies were envisaged.…”

Section: Introductionmentioning

confidence: 99%

“…The antivenin sera becomes lesser administrated, as long as the elapsed time to emergency is overdue. In fact, scorpion toxins are of rapid bio-distribution and tissular fixation (within few hours); which render antibodies incapable of their neutralization (Goyffon, 2002;Gueron and Yaron, 1970). In folk medicine, medical plants had occupied a great place.…”

Section: Introductionmentioning

confidence: 99%

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Aqueous leaves extract of Artemisia campestris inhibition of the scorpion venom induced hypertension

Hamed¹,

Serria²,

Lobna³

et al. 2014

J. Med. Plants Res.

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The boiled leaves of Artemisia campestris (Asteraceae) was used as a folk-medicine against ophidian and scorpion envenoming in rural and nomad populations, but its bona fide mechanisms are still unknown. In this report, the effect of the aqueous dry leaves' extract of this plant on hemodynamic variations induced by Buthus occitanus tunetanus venom was assayed in pregnant and non pregnant rats. Our results showed that the venom induced hypertension magnitude was much important in pregnant rats (maximal of 156% of baseline) than in cycling ones (maximal of 143.9% of baseline). When injected alone, the aqueous leaves extract of A. campestris induced a progressive significant diminishing of the mean arterial pressure both in 72.4 ± 7.6% and out of pregnancy (90.4 ± 4.4%). This effect did completely abolish the venom induced hypertensive shock, when envenomed rats were pretreated with the extract. It was concluded that aqueous extract of A. campestris leaves prevents the induced hypertensive phase induced by the scorpion venom, probably through adrenergic pathway. The potential of A. campestris water-boiled extract to revert hypertension is sought to be useful for antihypertensive drugs development; and worth much merit to be investigated.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aqueous leaves extract of Artemisia campestris inhibition of the scorpion venom induced hypertension

Hamed¹,

Serria²,

Lobna³

et al. 2014

J. Med. Plants Res.

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“…Leiurus quinquestriatus venom is the most toxic reported among scorpion species (LD50: 0.25 mg/kg), capable of provoking both dysfunction and failure of cardiovascular and respiratory systems (13)(14)(15)(16)(17)(18)(19)(20)(21). Neurotoxic venoms are particularly toxic to infants and young children, due to their weight-dependent effects (14).…”

Section: Introductionmentioning

confidence: 99%

“…Neurotoxic venoms are particularly toxic to infants and young children, due to their weight-dependent effects (14).…”

Section: Introductionmentioning

confidence: 99%

Notes on gestation periods and litter size in the arenicolous buthid scorpion Leiurus quinquestriatus (Ehrenberg, 1828) (Scorpiones: Buthidae)

Ross¹

2009

J. Venom. Anim. Toxins incl. Trop. Dis

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High blood pressure. A side effect of drugs, poisons, and food

Grossman

Messerli²

1995

Archives of Internal Medicine

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A variety of therapeutic agents or chemical substances can induce either a transient or a sustained increase in blood pressure. These agents increase arterial pressure by either causing sodium retention and extracellular volume expansion or directly or indirectly activating the sympathetic nervous system. Some agents act directly on arteriolar smooth muscle. For certain agents, the mechanism of pressure elevation is mixed or unknown. Paradoxically, some agents that are used to lower arterial pressure may acutely increase arterial pressure. Also, a rebound increase in pressure may be encountered after discontinuation of certain antihypertensive agents. In general, these chemically induced increases in arterial pressure are small and transient; however, severe hypertension involving encephalopathy, stroke, and irreversible renal failure has been reported. Careful evaluation of a patient's drug regimen may identify chemically induced hypertension and prevent the need for evaluation and therapy. This study reviews the therapeutic agents or chemical substances that elevate blood pressure and their mechanisms of action.

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Cardiovascular Manifestations of Severe Scorpion Sting

Cited by 167 publications

References 13 publications

Aqueous leaves extract of Artemisia campestris inhibition of the scorpion venom induced hypertension

Aqueous leaves extract of Artemisia campestris inhibition of the scorpion venom induced hypertension

Notes on gestation periods and litter size in the arenicolous buthid scorpion Leiurus quinquestriatus (Ehrenberg, 1828) (Scorpiones: Buthidae)

High blood pressure. A side effect of drugs, poisons, and food

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