Cardiovascular Manifestations in Patients With Thyrotoxicosis Based on Aetiology

Abstract

BACKGROUNDThyrotoxicosis may present with different cardiovascular manifestations varying from sinus tachycardia to life threatening arrhythmias and heart failure and prevalence of these features differs with various aetiologies of thyrotoxicosis.

Clinical profile of thyrotoxicosis and related cardiovascular morbidities among patients attending endocrine outpatient department in a tertiary care centre

“…A similar study conducted by Shetty et al reported 61.3% of patients with Grave's disease having tachycardia. 10 Mean age in participants with Grave's disease was 42.1 years, in thyroiditis it was 45 years, in MNG it was 40.46 whereas in toxic adenoma it was 39.91 years. The study conducted by Shetty et al revealed mean age in Grave's disease to be 43.49 years, in thyroiditis as 48.8 years and in MNG as 46.9 years.…”

“…A study conducted by Shetty et al also revealed Graves' disease as the commonest cause of thyrotoxicosis. 10 Weight loss (38.66%) and palpitations (25.33%) were predominant symptoms in participants with Grave's disease; those with thyroiditis had neck pain as the most common symptom (17.3%). Multi nodular goiter had neck swelling as the commonest symptom (11.3%) whereas weight loss (4%) and palpitations (4%) were predominant symptoms in participants with toxic adenoma.…”

“…The study conducted by Shetty et al revealed mean age in Grave's disease to be 43.49 years, in thyroiditis as 48.8 years and in MNG as 46.9 years. 10 Hypertension was observed in 52% (78) of participants. Most of them belonged to the age group of 31-40 years.…”

“…These include heart failure, arrhythmias including atrial fibrillation and atrial flutter. 10 Cardiovascular manifestations are due to direct cellular effects of thyroid hormones on the heart and indirect effects due to interaction with sympathetic nervous system and changes in peripheral vascular smooth muscle cells. 11 Available literature reveals association between thyrotoxicosis and cardiovascular diseases.…”

“…11 Available literature reveals association between thyrotoxicosis and cardiovascular diseases. 10,11 Our center being in central India; gets many patients from surrounding states. Also, many patients of thyrotoxicosis attending our tertiary care endocrine clinic present with symptoms suggestive of cardiovascular involvement.…”