Cardiovascular Magnetic Resonance Perfusion Imaging at 3-Tesla for the Detection of Coronary Artery Disease

Cheng, Adrian S. H.; Pegg, Tammy; Karamitsos, Theodoros D.; Searle, Nick; Jerosch‐Herold, Michael; Choudhury, Robin P.; Banning, Adrian P.; Neubauer, Stefan; Robson, Matthew D.; Selvanayagam, Joseph B.

doi:10.1016/j.jacc.2007.03.028

Cited by 191 publications

(129 citation statements)

References 25 publications

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“…Gadolinium chelates do not enter intact cell membranes and the volume of distribution is restricted to approximately 20% in normal viable myocardium (24). Different extravascular, extracellular contrast medium dose administration protocols and pulse sequences have been tested and validated in animal experiments (25)(26)(27), which have been subsequently translated into human studies (28)(29)(30)(31)(32)(33).…”

Section: Mbf Measurement: Recent Advances Cmrmentioning

confidence: 99%

“…On the other hand, increased field inhomogeneities can lead to more artifacts in perfusion imaging. In a pilot study in 65 patients, Cheng et al reported that 3-T CMR perfusion imaging provides an improved diagnostic accuracy, sensitivity, and specificity for the detection of significant coronary stenosis perfusion imaging (30). Pulse sequences to perform CMR perfusion at 3 T are commercially available, and it is conceivable that in the near future more data will be available to analyze the performance of higher-magnetic-field-strength systems on a large scale.…”

Section: Mbf Measurement: Recent Advances Cmrmentioning

confidence: 99%

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The Clinical Value of Myocardial Blood Flow Measurement

2009

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PET provides robust and reproducible measurements of regional myocardial blood flow in milliliters per minute per gram of tissue, providing unique pathophysiologic and diagnostic information on the function of the coronary macro-and microcirculation. There is compelling evidence to suggest that in many instances abnormalities of global myocardial perfusion are demonstrated in individuals with either coronary risk factors for coronary artery disease or different myocardial diseases in the absence of angiographically demonstrable stenosis of the epicardial coronary arteries. In this context, measurement of myocardial blood flow gives unique diagnostic information regarding the function of the coronary microcirculation and provides a quantitative surrogate endpoint against which the efficacy of treatments can be established.

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Section: Mbf Measurement: Recent Advances Cmrmentioning

confidence: 99%

Section: Mbf Measurement: Recent Advances Cmrmentioning

confidence: 99%

The Clinical Value of Myocardial Blood Flow Measurement

2009

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“…The percentage of amino acid sequence homology of A 2A AR in the three species was determined to be as follows: human vs. rat 82 %, human vs. mouse 82 %, and rat vs. mouse 96 %. Adenosine (Adenoscan®) and regadenoson (Lexiscan®) are used in myocardial stress imaging acting on A 2A ARs of coronary blood vessels which leads to dilation and a drop in blood pressure [20,21]. The A 2A AR represents one of the most important regulators of the innate immune response.…”

Section: Introductionmentioning

confidence: 99%

Selectivity is species-dependent: Characterization of standard agonists and antagonists at human, rat, and mouse adenosine receptors

Alnouri

Jepards

Casari

et al. 2015

Purinergic Signalling

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Adenosine receptors (ARs) have emerged as new drug targets. The majority of data on affinity/potency and selectivity of AR ligands described in the literature has been obtained for the human species. However, preclinical studies are mostly performed in mouse or rat, and standard AR agonists and antagonists are frequently used for studies in rodents without knowing their selectivity in the investigated species. In the present study, we selected a set of frequently used standard AR ligands, 8 agonists and 16 antagonists, and investigated them in radioligand binding studies at all four AR subtypes, A 1 , A 2A , A 2B , and A 3 , of three species, human, rat, and mouse. Recommended, selective agonists include CCPA (for A 1 AR of rat and mouse), CGS-21680 (for A 2A AR of rat), and Cl-IB-MECA (for A 3 AR of all three species). The functionally selective partial A 2B agonist BAY60-6583 was found to additionally bind to A 1 and A 3 AR and act as an antagonist at both receptor subtypes. The antagonists PSB-36 (A 1 ), preladenant (A 2A ), and PSB-603 (A 2B ) displayed high selectivity in all three investigated species. MRS-1523 acts as a selective A 3 AR antagonist in human and rat, but is only moderately selective in mouse. The comprehensive data presented herein provide a solid basis for selecting suitable AR ligands for biological studies.

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“…Während die Gewinnung funktioneller Parameter ähnliche Ergebnisse bei 1,5 und 3 T liefert [82,84], scheinen sich Vorteile von 3 T vor allem bei kontrastmittelunterstützten Techniken (Angiografien, Vitalitätsdiagnostik und Perfusion) abzuzeichnen. So konnte beispielsweise bei 3 T im direkten Patienten-und Feldstärkever-gleich eine erhöhte Sensitivität, Genauigkeit und Spezifizität der Adenosin-Stress-Perfusion zum Nachweis von hämodynamisch relevanten Koronarstenosen bei Verdacht auf koronare Herzkrankheit gefunden werden [85]. Dies wird jedoch in einer aktuellen Metaanalyse [86] drastisch relativiert.…”

Section: Tesla-mrt In Der Herzbildgebungunclassified

Klinischer Stellenwert und Indikationen zur Magnetresonanztomografie des Herzens 2013: Ein interdisziplinäres Expertenstatement

Hergan

Globits²,

Schuchlenz

et al. 2013

Fortschr Röntgenstr

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Zusammenfassung Obwohl in den letzten Jahren wissenschaftlich weitere Indikationen f?r die Magnetresonanztomografie (MRT) des Herzens erarbeitet wurden, hat sich die Akzeptanz dieser Untersuchungstechnik in Klinik und Praxis bei den Kardiologen und Radiologen nicht mit der gleichen Geschwindigkeit entwickelt wie die diagnostischen M?glichkeiten. Verantwortlich daf?r sind unter anderem die notwendige kostspielige Ausstattung, die relativ lange Untersuchungszeit, das hohe Ma? an technischem Wissen und nicht zuletzt die fehlende oder unzureichende Remuneration. Dar?ber hinaus sind ein Festhalten an traditionellen Abkl?rungsalgorithmen, ein limitierter Zugang zu dieser Technologie sowie Probleme in der f?cher?bergreifenden Kooperation zu beobachten. Die seit vielen Jahren bestehende interdisziplin?re Kooperation hat die Aufgabe, einen substanziellen Beitrag zur ?berwindung der genannten Problemfelder zu leisten und die MRT des Herzens in das Abkl?rungsspektrum kardialer Erkrankungen als fixen Bestandteil zu integrieren. Eine kontinuierliche Verbesserung der Behandlung von Patienten mittels kosteneffizienter Diagnostik und Therapie hat hierbei h?chste Priorit?t. Die MRT des Herzens spielt dabei eine bedeutende Rolle.

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Cardiovascular Magnetic Resonance Perfusion Imaging at 3-Tesla for the Detection of Coronary Artery Disease

Abstract: Our study showed that 3-T CMR perfusion imaging is superior to 1.5-T for prediction of significant single- and multi-vessel coronary disease, and 3-T may become the preferred CMR field strength for myocardial perfusion assessment in clinical practice.

Cited by 191 publications

References 25 publications

The Clinical Value of Myocardial Blood Flow Measurement

The Clinical Value of Myocardial Blood Flow Measurement

Selectivity is species-dependent: Characterization of standard agonists and antagonists at human, rat, and mouse adenosine receptors

Klinischer Stellenwert und Indikationen zur Magnetresonanztomografie des Herzens 2013: Ein interdisziplinäres Expertenstatement

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