Cardiovascular magnetic resonance imaging pattern in patients with autoimmune rheumatic diseases and ventricular tachycardia with preserved ejection fraction

Mavrogeni, Sophie; Sfikakis, Petros P.; Markousis‐Mavrogenis, George; Bournia, Vasiliki-Kalliopi; Poulos, George; Κουτσογεωργοπούλου, Λουκία; Karabela, Georgia; Stavropoulos, Efthymios; Katsifis, Gikas; Boki, Kyriaki; Vartela, Vasiliki; Kolovou, Genovefa; Theodorakis, George; Kitas, George D.

doi:10.1016/j.ijcard.2018.10.067

Cited by 24 publications

(31 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…T1-mapping was performed using a modified Look-Locker inversion recovery (MOLLI) sequence with a 3(3)5 scheme on 3 representative short-axis positions before and 15 min after contrast-medium administration. ECV was calculated from native and post contrast T1 mapping using the previously described equation [18]. T2-mapping was performed on 3 corresponding LV short axis slices using a black-blood prepared, navigator-gated, free-breathing hybrid gradient (echo planar imaging) and spin-echo multi-echo sequence [18].…”

Section: Methodsmentioning

confidence: 99%

“…ECV was calculated from native and post contrast T1 mapping using the previously described equation [18]. T2-mapping was performed on 3 corresponding LV short axis slices using a black-blood prepared, navigator-gated, free-breathing hybrid gradient (echo planar imaging) and spin-echo multi-echo sequence [18].…”

Section: Methodsmentioning

confidence: 99%

“…The presence and pattern of non-ischemic LGE lesions were qualitatively assessed by consensus agreement of two experienced observers. Native and post-contrast T1 maps, T2 maps and ECV were generated using dedicated plug-ins written for the OsiriX software as described previously [18]. Global native/post-contrast myocardial T1, ECV, and T2 values were calculated as the mean value of 3 short-axis slices.…”

Section: Cmr Data Analysismentioning

confidence: 99%

“…The accuracy of the T1 and T2 mapping methods was evaluated by a relaxometry study in a Eurospin Gel-Phantom (TO5, Diagnostic Sonar LTD, Livingston, Scotland): the comparison of T1 values Diagnostics 2019, 9, 220 4 of 11 obtained by the MOLLI 3(3)5 and a reference scan has been previously reported [18]. T2 values obtained by the black-blood-prepared multiecho hybrid gradient and spin-echo sequence were compared with a spin-echo reference sequence with 16 echoes, 8-ms echo spacing, and 10-s time to repetition.…”

Section: Validation Of T1 and T2 Measurementsmentioning

confidence: 99%

“…T2 values obtained by the black-blood-prepared multiecho hybrid gradient and spin-echo sequence were compared with a spin-echo reference sequence with 16 echoes, 8-ms echo spacing, and 10-s time to repetition. Furthermore, myocardial T2 values were measured in 16 myocardial segments in an additional control group to assess reproducibility and regional variations of estimated myocardial T2 [18]. This control group consisted of 20 healthy subjects with a median age of 25 years (range 24-28 years) without symptoms or a history of any cardiovascular disease.…”

Section: Validation Of T1 and T2 Measurementsmentioning

confidence: 99%

See 4 more Smart Citations

Cardiovascular Magnetic Resonance Identifies High-Risk Systemic Sclerosis Patients with Normal Echocardiograms and Provides Incremental Prognostic Value

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background: Acute cardiac events are a significant contributor to mortality in systemic sclerosis (SSc). However, echocardiographic evaluation may be deceptively normal during an acute presentation. We hypothesized that in diffuse SSc patients presenting with acute cardiac events and a normal echocardiogram, cardiovascular magnetic resonance (CMR) would have incremental diagnostic/prognostic value. Methods. 50 consecutive diffuse SSc patients with normal echocardiograms were evaluated using a 1.5T system. A total of 27 (63%) had experienced an acute cardiac event three to tendays before CMR evaluation (rhythm disturbances, angina pectoris, shortness of breath). Left/right ventricular (LV/RV) volumes and ejection fractions (EF), as well as LV mass, the T2-signal ratio, early/late gadolinium enhancement (EGE/LGE), native/post-contrast T1-mapping, T2-mapping and extracellular volume fraction (ECV) were compared between the event and no-event groups. Results: No differences were identified in LV/RV volumes/EF/mass. In logistic regression analyses, independent predictors of belonging to the event group were EGE (odds ratio (95% CI): 1.55 (1.06-2.26), p = 0.024), LGE (1.81 (1.23-2.67), p = 0.003), T2 mapping (1.20 (1.06-1.36), p = 0.004) and native/post-contrast T1 mapping (1.17 (1.04-1.32), p = 0.007 and 0.86 (0.75-0.98), p = 0.025). At a median follow-up of~1.2 years, 42% vs. 11% of the event/no-event group respectively reached a combined endpoint of event occurrence/recurrence or cardiovascular mortality. Of the independent predictors resulting from logistic regression analyses, only LGE (hazard ratio (95% CI): 1.20 (1.11-1.30), p < 0.001), T2-mapping (1.07 (1.01-1.14), p = 0.025) and native T1-mapping (1.08 (1.01-1.15), p = 0.017) independently predicted the combined endpoint. Conclusions: A normal echocardiogram does not preclude myocardial lesions in diffuse SSc patients, which can be detected by CMR especially in symptomatic patients.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Cmr Data Analysismentioning

confidence: 99%

Section: Validation Of T1 and T2 Measurementsmentioning

confidence: 99%

Section: Validation Of T1 and T2 Measurementsmentioning

confidence: 99%

See 3 more Smart Citations

Cardiovascular Magnetic Resonance Identifies High-Risk Systemic Sclerosis Patients with Normal Echocardiograms and Provides Incremental Prognostic Value

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

Normal myocardial native T₁ values in children using single‐point saturation recovery and modified look–locker inversion recovery (MOLLI)

Burkhardt

Menghini

Rücker

et al. 2019

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Background T1 mapping is useful to quantify diffuse myocardial processes such as fibrosis, edema, storage disorders, or hemochromatosis. Normal pediatric myocardial T1 values are scarce using modified Look–Locker inversion recovery (MOLLI) sequences and unavailable using Smart1Map, a single‐point saturation recovery sequence that measures true T1. Purpose/Hypothesis To establish normal pediatric myocardial T1 values by Smart1Map and to compare them with T1 by MOLLI. Study Type Prospective cohort study. Subjects Thirty‐four children and adolescents aged 8–18 years (14 males) without cardiovascular or inflammatory diseases. Field Strength/Sequences 1.5T, MOLLI, Smart1Map. Assessment Mean T1 values of the left ventricular myocardium, the interventricular septum, and the blood pool were measured with MOLLI and Smart1Map in basal, mid‐ventricular, and apical short axis slices. Statistical Tests T1 values were compared between locations and methods by paired samples t‐tests, Wilcoxon signed ranks test, repeated‐measures analysis of variance (ANOVA), or Friedman's test. Pearson's correlation coefficient was calculated. For interobserver variability, intraclass correlation coefficients and coefficients of variation were calculated, and Bland–Altman analyses were performed. Results T1 values were longer by Smart1Map than by MOLLI in all measured locations (myocardium: 1191–1221 vs. 990–1042 msec; all P < 0.001). T1 in basal vs. mid‐ventricular slices differed both by MOLLI and by Smart1Map for myocardium and for blood (all P < 0.001). Myocardial T1 did not correlate with age, heart rate, right or left ventricular ejection fraction (all P > 0.05) by either method. Septal vs. total myocardial T1 values in each slice did not differ by MOLLI (basal P = 0.371; mid‐ventricular P = 0.08; apical P = 0.378) nor by Smart1Map (basal P = 0.056; mid‐ventricular P = 0.918; apical P = 0. 392), after artifacts had been carefully excluded. Data Conclusion We established pediatric normal native T1 values using the Smart1Map sequence and compared the results with T1 mapping with MOLLI. Septal T1 values did not differ from total myocardial T1 values in each of the myocardial slices. Level of Evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:897–903.

show abstract

Current understanding and future perspectives of brain–heart–kidney axis in psoriatic arthritis

et al. 2020

View full text Add to dashboard Cite

Cardiovascular magnetic resonance imaging pattern in patients with autoimmune rheumatic diseases and ventricular tachycardia with preserved ejection fraction

Cited by 24 publications

References 35 publications

Cardiovascular Magnetic Resonance Identifies High-Risk Systemic Sclerosis Patients with Normal Echocardiograms and Provides Incremental Prognostic Value

Cardiovascular Magnetic Resonance Identifies High-Risk Systemic Sclerosis Patients with Normal Echocardiograms and Provides Incremental Prognostic Value

Normal myocardial native T₁ values in children using single‐point saturation recovery and modified look–locker inversion recovery (MOLLI)

Current understanding and future perspectives of brain–heart–kidney axis in psoriatic arthritis

Contact Info

Product

Resources

About

Cardiovascular magnetic resonance imaging pattern in patients with autoimmune rheumatic diseases and ventricular tachycardia with preserved ejection fraction

Cited by 24 publications

References 35 publications

Cardiovascular Magnetic Resonance Identifies High-Risk Systemic Sclerosis Patients with Normal Echocardiograms and Provides Incremental Prognostic Value

Cardiovascular Magnetic Resonance Identifies High-Risk Systemic Sclerosis Patients with Normal Echocardiograms and Provides Incremental Prognostic Value

Normal myocardial native T1 values in children using single‐point saturation recovery and modified look–locker inversion recovery (MOLLI)

Current understanding and future perspectives of brain–heart–kidney axis in psoriatic arthritis

Contact Info

Product

Resources

About

Normal myocardial native T₁ values in children using single‐point saturation recovery and modified look–locker inversion recovery (MOLLI)