Cardiovascular Magnetic Resonance Imaging Detects Cardiac Involvement in Churg-Strauss Syndrome

Waßmuth, Ralf; Göbel, U; Natusch, Alexander; Schneider, Wolfgang; Kettritz, Ralph; Dietz, Rainer; Luft, Friedrich C.; Schulz‐Menger, Jeanette

doi:10.1016/j.cardfail.2008.07.227

Cited by 71 publications

(71 citation statements)

References 19 publications

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“…5 Nevertheless, the resolution of LGE lesions cannot be ruled out in subjects with signs of myocarditis on CMR. 31,32 In the current study, LGE lesions represented predominantly nonischemic myocardial damage; obvi- ously, we could not unequivocally exclude their ischemic origin if they involved the subendocardium. 33 The volume and extent of LGE lesions were directly associated with the maximum level of blood eosinophil count at disease diagnosis.…”

Section: Discussionmentioning

confidence: 64%

“…10,28,36 In addition, both scenarios were also observed in other types of myocardial inflammation, including vasculitis and viral etiology, and were linked to prognosis. 31,32 Prior case reports documented the ability of CMR to depict eosinophilic myocarditis in HES confirmed by endomyocardial biopsy. 9,25,28 In the current study, despite the apparent clinical and laboratory control of disease, 3 women demonstrated CMR evidence of myocarditis.…”

Section: Discussionmentioning

confidence: 99%

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MRI-based Evidence for Myocardial Involvement in Women with Hypereosinophilic Syndrome

et al. 2015

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Purpose: The aim of the study was to assess the presence and spectrum of cardiac abnormalities identified by cardiac magnetic resonance (CMR) in women with hypereosinophilic syndrome (HES) of undefined etiology, who present with normal electrocardiography (ECG) and transthoracic echocardiography (TTE) and no history of heart disease.Methods: Ten women (mean age, 48 « 14 years) with HES of undefined etiology, normal ECG and TTE, and no history of heart disease underwent CMR.Results: CMR showed cardiac abnormalities in 6 subjects. Five patients had nonischemic late gadolinium enhancement (LGE) lesions within the left ventricular (LV) myocardium, and 3 patients demonstrated CMR evidence of myocardial inflammation. The LV ejection fraction was 68.5 « 5.7%, and the end-diastolic volume index was 62.7 « 14.7 mL/m 2 . The maximum measured blood eosinophil count correlated with LVLGE volume (r = 0.80, P = 0.006) and was 11374 « 6242 cells/µL and 4114 « 2972 cells/µL (P = 0.047) in patients with and without LGE lesions, respectively. The actual blood eosinophil count in subjects with and without CMR evidence of myocarditis was 1058 « 520 cells/µL and 354 « 377 cells/µL (P = 0.04), respectively.Conclusions: Despite normal ECG, TTE, and absence of history of heart disease, women with HES of unknown etiology frequently demonstrate cardiac abnormalities on CMR, the presence and extent of which are related to blood eosinophil count.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

MRI-based Evidence for Myocardial Involvement in Women with Hypereosinophilic Syndrome

et al. 2015

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“…Finally, phrenic paralysis, presumably of ischemic origin, is rarely seen (Noth et al 2003;Lhote 2007). Otorhinolaryngological involvement occurs in 50-100% of patients (Reid et al 1998;Wassmuth et al 2008). It is often observed early in the course of the disease and includes an allergic rhinitis or nasal polyps leading to nasal obstruction, and a recurrent paranasal sinusitis.…”

Section: Respiratory and Otorhinolaryngological Manifestationsmentioning

confidence: 99%

“…Infrequently reported cardiac involvement includes impaired myocardial perfusion leading to ischemic cardiomyopathy, cardiac wall motion anomalies, constrictive pericarditis, endomyocardial fibrosis, eosinophilic coronary arteritis, coronary dissection, valvular regurgitation, conduction disturbances and arrhythmias, and isolated ventricular septum involvement. Pulmonary hypertension is rare (Hunsaker et al 1992;Davies 2005;Alter and Maisch 2006;Pela et al 2006;Lhote et al 2008;Wassmuth et al 2008;Mavrogeni et al 2009;Rosato et al 2009;Dennert et al 2010;Sauvetre et al 2010). …”

Section: Cardiac Manifestationsmentioning

confidence: 99%

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Churg–Strauss Syndrome

Bouhaouala¹,

Bouslama²,

Charfi³

et al. 2011

Systemic Vasculitis

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Eosinophilic Granulomatosis with Polyangiitis: A Systematic Review and Meta‐Analysis of Test Accuracy and Benefits and Harms of Common Treatments

Springer

Kalot

Husainat

et al. 2021

ACR Open Rheumatology

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Objective Eosinophilic granulomatosis with polyangiitis (EGPA) is part of a group of vasculitides commonly referred to as antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV), in addition to granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and renal‐limited vasculitis. Patients with EGPA characteristically have asthma and marked peripheral eosinophilia with only approximately 30% to 35% of patients being myeloperoxidase (MPO)‐ANCA positive, distinguishing it from other forms of AAV (1,2). The aim of this systematic review is to support the development of the American College of Rheumatology/Vasculitis Foundation guideline for the management of EGPA. Methods A systematic review was conducted of the literature for seven forms of primary systemic vasculitis (GPA, MPA, EGPA, polyarteritis nodosa, Kawasaki disease, giant cell arteritis, and Takayasu arteritis). The search was done for articles in English using Ovid Medline, PubMed, Embase, and the Cochrane Library. Articles were screened for suitability in addressing population/patients, intervention, comparator, and outcomes (PICO) questions, with studies presenting the highest level of evidence given preference. Two independent reviewers conducted a title/abstract screen and full‐text review for each eligible study. Results The initial search, conducted in August 2019, included 13 800 articles, of which 2596 full‐text articles were reviewed. There were 190 articles (addressing 34 PICO questions) reporting on the diagnosis and management of EGPA. Conclusion This comprehensive systematic review synthesizes and evaluates the accuracy of commonly used tests for EGPA as well as benefits and toxicities of different treatment options.

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Cardiovascular Magnetic Resonance Imaging Detects Cardiac Involvement in Churg-Strauss Syndrome

Cited by 71 publications

References 19 publications

MRI-based Evidence for Myocardial Involvement in Women with Hypereosinophilic Syndrome

MRI-based Evidence for Myocardial Involvement in Women with Hypereosinophilic Syndrome

Churg–Strauss Syndrome

Eosinophilic Granulomatosis with Polyangiitis: A Systematic Review and Meta‐Analysis of Test Accuracy and Benefits and Harms of Common Treatments

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