Cardiovascular, Inflammatory, and Metabolic Consequences of Sleep Deprivation

Mullington, Janet; Haack, Monika; Tóth, Mária; Serrador, Jorge M.; Meier-Ewert, Hans K.

doi:10.1016/j.pcad.2008.10.003

Cited by 641 publications

(460 citation statements)

References 68 publications

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“…Second, aside from SDB, insufficient sleep and other sleep disorders such as insomnia, which may undermine patients' sleep quality and cause EDS, have also been associated with poor cardiovascular outcomes 27. Third, although the basic mechanistic correlation between EDS and cardiovascular disorders remains unclear, assessment of inflammation, sympathetic overdrive, oxidative stress, and endocrine dysfunction, as found in sleep‐deprived participants, may provide insights into the mechanisms linking EDS to cardiovascular outcomes in post‐MI patients 28, 29, 30…”

Section: Discussionmentioning

confidence: 99%

Excessive Daytime Sleepiness Independently Predicts Increased Cardiovascular Risk After Myocardial Infarction

Xie

Kuniyoshi

Covassin

et al. 2018

JAHA

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BackgroundExcessive daytime sleepiness (EDS), a common symptom among patients with sleep‐disordered breathing, is closely associated with the development of cardiovascular diseases, but its long‐term prognostic value is not completely understood. The aim of this study was to investigate whether EDS would be an independent prognostic factor after myocardial infarction.Methods and ResultsWe prospectively recruited 112 post–myocardial infarction patients. The Epworth Sleepiness Scale was completed before polysomnography, and EDS was defined as a score ≥11. After exclusion of 8 patients who accepted treatment with continuous positive airway pressure, 104 patients were followed up for 48 months. The primary composite end point was major adverse cardiac events. Patients with EDS had higher rates of major adverse cardiac events (48.4% versus 27.4%, χ2=5.27, P=0.022) and reinfarction (29.0% versus 5.5%, χ2=13.51, P=0.0002) compared with those without EDS. In the Cox proportional hazards model, patients with EDS had 2.15 times (95% confidence interval, 1.08–4.18; P=0.030) higher crude risk of major adverse cardiac events, with prognostic significance persisting after adjusting for age, diabetes mellitus, depression, left ventricular ejection fraction, apnea–hypopnea index, and nocturnal nadir oxygen saturation (hazard ratio: 2.13, 95% confidence interval, 1.04–4.26, P=0.039). Furthermore, among participants with moderate to severe sleep‐disordered breathing, the presence of EDS was associated with higher risk of major adverse cardiac events than those without EDS, after adjusting for age and nadir oxygen saturation (hazard ratio: 3.17, 95% confidence interval, 1.22–7.76, P=0.019).Conclusions EDS may be an independent prognostic factor of adverse outcome in post–myocardial infarction patients with moderate to severe sleep‐disordered breathing. Evaluation of EDS may shed new light on risk stratification and identify treatment responders for this patient population.

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Section: Discussionmentioning

confidence: 99%

Excessive Daytime Sleepiness Independently Predicts Increased Cardiovascular Risk After Myocardial Infarction

Xie

Kuniyoshi

Covassin

et al. 2018

JAHA

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“…Insufficient sleep can increase food intake and maintain energy in the body via organizing some neuroendocrine, metabolic and behavioral compatibility (39). Increased weight and appetite changes might be related to changes in leptin and ghrelin concentrations induced by sleep limitation and changes in work shifts (40). Police officers, who had sleep hours of less than five showed higher levels of leptin than those with five to seven hours of sleep (41).…”

Section: Discussionmentioning

confidence: 99%

The Association Between Sleep Quality and Metabolic Factors and Anthropometric Measurements

Khorasani¹,

Mohammadpoorasl²,

Javadi³

2016

Biotech Health Sci

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Background: Several studies have shown that sleep disorders may lead to metabolic or endocrine changes including insulin resistance, diabetes, obesity, cardiovascular disease and stroke. Objectives: The aim of this study was to investigate the association between sleep quality and metabolic factors and anthropometric measurements among personnel of a central petrochemical company in Tehran. Methods: This cross-sectional study was conducted on 400 personnel of a central petrochemical company in Tehran, during year 2015. Demographic information including age, gender, educational status, employment duration, working hours per day, marital status, smoking, medical history for disease and drug use, were collected by a questionnaire. Systolic and diastolic blood pressure and also height and weight were measured by standard methods and body mass index (BMI) was calculated. Pittsburg sleep quality index (PSQI) was performed to assess participants' sleep quality. Serum concentrations of fasting glucose and lipid profiles were measured by the related biochemical kits. Logistic regression analysis was used for multivariate adjusting of factors associated with sleep quality.

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“…Furthermore, chronic sleep deprivation and sleep restriction have been shown to have adverse effects on health. Deleterious effects include increased neurobehavioral deficits, blood pressure, body mass index and obesity, adverse cardiovascular events, elevated inflammatory markers and impaired glucose tolerance [40,41]. Consequently, it is important to understand the effect of working on-call from home on sleep.…”

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confidence: 99%

The effect of working on-call on stress physiology and sleep: A systematic review

Hall

Ferguson

Turner

et al. 2017

Sleep Medicine Reviews

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SUMMARYOn-call work is becoming an increasingly common work pattern, yet the human impacts of this type of work are not well established. Given the likelihood of calls to occur outside regular work hours, it is important to consider the potential impact of working on-call on stress physiology and sleep. The aims of this review were to collate and evaluate evidence on the effects of working on-call from home on stress physiology and sleep. A systematic search of Ebsco Host, Embase, Web of Science, Scopus and ScienceDirect was conducted. Search terms included: on-call, on call, standby, sleep, cortisol, heart rate, adrenaline, noradrenaline, nor-adrenaline, epinephrine, norepinephrine, nor-epinephrine, salivary alpha amylase and alpha amylase. Eight studies met the inclusion criteria, with only one study investigating the effect of working on-call from home on stress physiology. All eight studies investigated the effect of working on-call from home on sleep. Working on-call from home appears to adversely affect sleep quantity, and in most cases, sleep quality. However, studies did not differentiate between night's on-call from home with and without calls. Data examining the effect of working on-call from home on stress physiology were not sufficient to draw meaningful conclusions. KEYWORDSOn-call; standby; sleep quality; sleep quantity; hypothalamo-pituitary adrenal axis; cortisol; sympatho-adrenal medullary system; sleep. ABBREVIATIONSEPHPP: Effective public health practice project PRISMA: Preferred reporting items for systematic reviews and meta-analyses SD: Standard deviation

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Cardiovascular, Inflammatory, and Metabolic Consequences of Sleep Deprivation

Cited by 641 publications

References 68 publications

Excessive Daytime Sleepiness Independently Predicts Increased Cardiovascular Risk After Myocardial Infarction

Excessive Daytime Sleepiness Independently Predicts Increased Cardiovascular Risk After Myocardial Infarction

The Association Between Sleep Quality and Metabolic Factors and Anthropometric Measurements

The effect of working on-call on stress physiology and sleep: A systematic review

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