Cardiovascular health of patients with cancer: Challenges abound

Chan, Jeffrey Shi Kai; Chan, Raymond Ngai Chiu; Lee, Yan Hiu Athena; Satti, Danish Iltaf; Dee, Edward Christopher; Ng, Kenrick; Achim, Alexandru; Ng, Chi Fai; Liu, Tong; Matthews, Gareth D K; Tse, Gary; Vassiliou, Vassilios S

doi:10.1016/j.tcm.2024.04.004

Cited by 2 publications

(3 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whether the observed SDOHmortality associations differ by race/ethnicity also warrants further research. 1,10 Notwithstanding this study's nationally representative nature, it was limited by NHIS' self-reported nature, and the lack of individual data adjudication potentially predisposing to mortality data miscoding. Low event rates precluded subgroup/exploratory analyses, and the observational nature precluded causal inferences.…”

Section: Introductionmentioning

confidence: 99%

“…Social determinants of health (SDOH) are increasingly recognized to substantially influence cardiovascular health in both the general population and cancer survivors. 1,2 A recent nationwide cross-sectional study of cancer survivors found strong associations between SDOH and cardiovascular risk factors. 3 Despite known associations between SDOH and cardiovascular/cancer mortality in the general population, 4,5 these associations have rarely been studied at the individual level amongst cancer survivors – given their cancer history and elevated cardiovascular risk, 6 relevant associations observed in the general population may not be applicable to them.…”

mentioning

confidence: 99%

“…Whether the observed SDOH-mortality associations differ by race/ethnicity also warrants further research. 1,10…”

mentioning

confidence: 99%

See 2 more Smart Citations

Association between social determinants of health and cardiovascular and cancer mortality in cancer survivors: a nationally representative cohort study

Chan,

Satti,

Ching

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

Although it is known that social deprivation is associated with higher risks of cardiovascular and cancer mortality in the general population, these associations may not be directly applicable to cancer survivors. Using data from the National Health Interview Survey (NHIS) 2013-2017 with follow-up till the end of 2019, we examined the associations between social determinants of health (SDOH) and the risk of all-cause, cardiovascular, and cancer mortality in cancer survivors, with separate modelling in individuals without cancer for comparison. Two Cox regression models were fitted for each outcome, the first being adjusted for demographics and the second being additionally adjusted for comorbidities and risk factors. Altogether, 37,882 individuals were analysed (representing a weighted population of 57,696,771), including 4179 cancer survivors and 33,703 individuals without cancer. Amongst cancer survivors, worse SDOH was associated with higher all-cause, cardiovascular, and cancer mortality when adjusted for demographics, which were attenuated but remained significant when further adjusted for comorbidities and risk factors. Amongst individuals without cancer, worse SDOH was associated with higher all-cause and cardiovascular mortality only when adjusted for demographics, but not when further adjusted for comorbidities and risk factors. These suggested that in cancer survivors, associations between SDOH and cardiovascular/cancer mortality may be driven by factors beyond comorbidities and risk factors, contrasting individuals without cancer in whom similar associations were probably driven mostly by comorbidities and risk factors.

show abstract

Section: Introductionmentioning

confidence: 99%