Cardiovascular features of autonomous cortisol secretion in patients with adrenal incidentalomas

Sbardella, Emilia; Minnetti, Marianna; Rizzà, Laura; Giorgio, Maria Rosaria Di; Hasenmajer, Valeria; D’Aluisio, Denise; Morelli, Sergio; Lenzi, Andrea; Isidori, Andrea M.

doi:10.1530/endoabs.49.gp16

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“…Sbardella, with her team, also compared patients with mACS with patients with non-functioning adenomas. Patients with mACS presented increased LVM index, higher prevalence of diastolic dysfunction, higher prevalence of left ventricle hypertrophy and worse arterial stiffness 62 . Even though all recruited patients were asymptomatic, the results indicated that mACS can cause cardiac and vascular remodelling, which puts patients at higher cardiovascular risk.…”

Section: Introductionmentioning

confidence: 93%

Comorbidities in Mild Autonomous Cortisol Secretion – A Clinical Review of Literature

Czapla-Iskrzycka

Świątkowska−Stodulska

Sworczak

2022

Exp Clin Endocrinol Diabetes

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Mild autonomous cortisol secretion (mACS) is a state of cortisol excess usually associated with existence of adrenal incidentaloma. Because of the lack of symptoms of the disease, the biochemical evaluation is the most important to determine a diagnosis. However, scientific societies have different diagnostic criteria for mACS, which makes the treatment of this disease and using results of original papers in daily practice more difficult. Chronic hypercortisolemic state, even if mild, may lead to diseases that are mostly connected with overt Cushing’s syndrome. Some of them can cause a higher mortality of patients with mACS and those problems need to be addressed. In this review we describe the comorbidities associated with mACS: cardiovascular disorders, arterial hypertension, diabetes mellitus, insulin resistance, dyslipidemia, obesity, metabolic syndrome, non-alcoholic fatty liver disease, vertebral fractures and osteoporosis. The point of this paper is to characterise them and determine if and how these conditions should be managed. Two databases – PubMed and Web of Science were searched. Even though the evidence are scarce, this is an attempt to lead clinicians through the problems associated with this enigmatic condition.

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Section: Introductionmentioning

confidence: 93%