Cardiovascular Effects of Pancuronium and Vecuronium during High-Dose Fentanyl Anesthesia

Contribution of muscle relaxant to the haemodynamic course of high-dose fentanyl anaesthesia: a comparison of pan-curonium, vecuronium and atracurium

“…In our previous study, pancuronium did not accelerate heart rate over the awake control level but only reversed the decrease in heart rate and cardiac output caused by fentanyl, whereas vecuronium further decreased these parameters. 6 In that study, succinylcholine was administered for intubation, and pancuronium or vecuronium was administered later. It is therefore possible that the haemodynamic effects of pancuronium and vecuronium were modified by the effect of succinylcholine on the autonomic nervous system 14 or by the delay of the administration of the nondepolarising relaxant.…”

A comparison of pipecuronium with pancuronium on haemodynamic variables and plasma catecholamines in coronary artery bypass patients

“…14.is However, our investigation does confLrm the results of previous studies, that the administration of a 2 X EDg5 dose pancuronium after induction of anaesthesia induces a sustained increase in HR and CI regardless of the induction agent used. [16][17][18][19] This side effect of pancuronium may be attributed to its vagolytic t or sympath0mimetic properties, 2,3,2~ the latter probably being the reason that in our study MAP was higher after pancuronium than after pipecuronium.…”

Comparison of effects of rocuronium bromide versus vecuronium bromide on hemodynamic parameters during anaesthesia for elective surgical procedures

“…The studies have found that vecuronium itself does not cause decrease in heart rate (Cozantis et al). 10 The decrease in heart rate is seen when it is administered concurrently with other anaesthetic agents such as opioids, halothane (Salmenpern et al), 3 in surgical procedures with reflex vagal activity (laparotomy, cholecystctomy) (C.P.J. Morton et al).…”

“…Introduction of vecuronium and atracurium considerably improved flexibility in clinical administration of muscle relaxants due to their intermediate duration of action, favourable recovery and hemodynamic stability. However reports of bradycardia have appeared in literature in patients receiving vecuronium along with high dose of opiates, 3 β blocker therapy and in procedures with reflex vagal activity(strabismus surgery, laparotomy). 4 This may be due to inability of vecuronium to counterbalance various negative chronotropic effects.…”