Cardiovascular effects of inhalant anesthetic agents

Gross, David R.

doi:10.1007/978-94-017-0730-5_7

Cited by 1 publication

(1 citation statement)

References 140 publications

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“…If anesthetized animals are used, consideration should be given to the ancillary effects of the anesthetic on cardiovascular parameters, especially the QT interval. Most anesthetic agents affect hemodynamics and/or electrophysiology to the extent that their use should be restricted to special circumstances (26).…”

Section: Role Of Dog-in Vivomentioning

confidence: 99%

The Dog's Role in the Preclinical Assessment of QT Interval Prolongation

Gralinski¹

2003

Toxicol Pathol

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During the development of a new therapeutic, few pharmacodyamic outcomes currently receive as much scrutiny as the effect of a potential medication on the electrocardiographic QT interval. The recent withdrawal from marketing of several drugs due to potential drug-related cardiac arrhythmias have greatly increased concern about drug-related changes on the QT interval. In order to reduce the incidence of these idiosyncratic episodes, regulatory agencies have suggested that sponsors use more rigorous methodology during the safety evaluation of new pharmaceuticals. Along with enhanced electrocardiographic assessments during clinical trials, advanced preclinical examinations of effect on QT interval and ventricular repolarization have become de rigueur. In this arena, the beagle dog is the preclinical species often associated with the most reliable predictivity for human safety assessment. To this end, canine models of cardiovascular safety assessment are discussed along with the relevance of these assays to human electrocardiography.

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Section: Role Of Dog-in Vivomentioning

confidence: 99%

The Dog's Role in the Preclinical Assessment of QT Interval Prolongation

Gralinski¹

2003

Toxicol Pathol

View full text Add to dashboard Cite

show abstract

Cardiovascular effects of inhalant anesthetic agents

Cited by 1 publication

References 140 publications

The Dog's Role in the Preclinical Assessment of QT Interval Prolongation

The Dog's Role in the Preclinical Assessment of QT Interval Prolongation

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