2001
DOI: 10.1007/s004240100693
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Cardiovascular effects of fentanyl in conscious rats

Abstract: The polymicrobial sepsis induced by cecal ligation and puncture (CLP) in the rat is widely used in shock research. For ethical reasons, narcotic analgesics are often administered in this model, with the potential risk of confounding effects. In conscious non-septic rats, we investigated the cardiovascular effects of a continuous i.v. infusion of fentanyl (20 µg/kg per h) administered with fluid loading (10 ml/kg per h) for 24 h, a regimen commonly applied in rat CLP. Animals were randomly allocated to receive … Show more

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Cited by 3 publications
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“…50 In rodents, where long-term (>6 h) controlled ventilation is difficult, if not impossible, continuous fentanyl administration has to be evaluated carefully due to respiratory depression. 51,52 Other strategies may be the use of epidural analgesia 53 which again may be easier to apply in larger animals than in rodents. Of note, the immune-modulating effects of morphine affect mechanistic studies in sepsis models.…”
Section: Refinement Opportunities – Analgesics In Sepsis Modelsmentioning
confidence: 99%
“…50 In rodents, where long-term (>6 h) controlled ventilation is difficult, if not impossible, continuous fentanyl administration has to be evaluated carefully due to respiratory depression. 51,52 Other strategies may be the use of epidural analgesia 53 which again may be easier to apply in larger animals than in rodents. Of note, the immune-modulating effects of morphine affect mechanistic studies in sepsis models.…”
Section: Refinement Opportunities – Analgesics In Sepsis Modelsmentioning
confidence: 99%