Cardiovascular effects of fentanyl and propofol on hemodynamic function in rabbits

Baumgartner, Christine; Koenighaus, Hilke; Ebner, Johanna; Henke, Julia; Schuster, Tibor; Erhardt, W.

doi:10.2460/ajvr.70.3.409

Cited by 11 publications

(11 citation statements)

References 24 publications

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“…25,26 It can easily be examined by percutaneous ultrasonography, which has already been studied for its suitability to investigate vascular effects of drugs in several studies using goats and rabbits. [27][28][29][30][31] In our study, ultrasonography of the CCA was always performed by the same person (CB) to avoid variations in the technique of examination. The audible and visible signals as well as the Doppler angle of 45° to 60° were always comparable among the single measurements.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular effects of alfaxalone on hemodynamic function in pigs

Pfeiffer¹,

Ebner²,

Thaden³

et al. 2013

OAAP

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Background:The purpose of this study was to investigate the short-term cardiovascular effects of intravenous (IV) alfaxalone bolus injections in healthy pigs. Materials and methods: Each pig was sedated with ketamine, azaperone, and atropine intramuscularly, mixed in one syringe. Anesthesia was induced and maintained intravenously with alfaxalone. Then, three defined test bolus injections of alfaxalone were given intravenously. Vascular ultrasonography and pulse-induced contour cardiac output thermodilution monitoring were used to evaluate the direct cardiovascular effects after bolus injection. The following vascular and hemodynamic variables were recorded at the right common carotid artery (CCA) for 10 minutes after each alfaxalone injection by ultrasonography, pulse oximetry, and capnometry: peak systolic, minimum diastolic, end-diastolic, and time-averaged blood flow velocities; average volumetric flow; resistance index and vessel diameter; heart rate (HR); arterial oxygen saturation; and end-tidal carbon dioxide (PETCO 2 ). In addition, pulse contour-derived cardiac output recorded cardiac output, contractility, and volumetric variables for preload and afterload, as well as extravascular lung water, blood temperature, arterial blood pressure, and central venous pressure. Results: Alfaxalone bolus injections caused an initial short-lasting (0.25 minutes) decrease in diameter at the CCA after each bolus. During this very acute reaction, peak systolic blood flow velocity, thermodilutional cardiac output, and HR increased significantly. Average volumetric flow decreased, but not significantly. Mean arterial blood pressure decreased significantly at a time point of 0.25 minutes. Stroke volume, end-diastolic blood flow velocity, and resistance index did not change significantly. No cumulative effect was seen when three bolus injections of alfaxalone were given. Conclusion: Alfaxalone bolus injections produced two-phased short-lasting vascular (vasoconstriction at the CCA, vasodilation in the peripheral vessels) and hemodynamic changes (HR, mean arterial pressure), which were easily compensated by young healthy pigs. Because of those very short changes, alfaxalone is a safe hypnotic agent in healthy pigs; however, it may be used carefully in patients with ventricular dysfunction.

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Section: Discussionmentioning

confidence: 99%

Cardiovascular effects of alfaxalone on hemodynamic function in pigs

Pfeiffer¹,

Ebner²,

Thaden³

et al. 2013

OAAP

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“…administration of fentanyl at 2.5 µg/kg in goats [ 23 ] and at 4 µg/kg in horses [ 25 ], no significant change in heart rate was observed. Cardiovascular effects of fentanyl have been studied in laboratory animals [ 30 , 31 ]. In rabbits, administration of i.v.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetic Profile of Fentanyl in the Koala (Phascolarctos cinereus) after Intravenous Administration, and Absorption via a Transdermal Patch

Tokonami¹,

Kimble

Govendir

2021

Animals

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Fentanyl was administered as a single intravenous bolus injection at 5 µg/kg to five koalas and fentanyl plasma concentrations for a minimum of 2 h were quantified by an enzyme-linked immunosorbent assay (ELISA). The median (range) fentanyl elimination half-life and clearance were 0.53 (0.38–0.91) h, and 10.01 (7.03–11.69) L/kg/h, respectively. Assuming an analgesic therapeutic plasma concentration of 0.23 ng/mL (extrapolated from human studies), an intravenous constant infusion rate was estimated at approximately between 1.7 to 2.7 µg/kg/h (using the clearance 95% confidence intervals). A transdermal fentanyl patch was applied to the antebrachium of an additional two koalas for 72 h. Fentanyl plasma concentrations were determined during the patch application and after patch removal at 80 h. The fentanyl plasma concentration was greater than 0.23 ng/mL after 12 to 16 h. While the patch was applied, the maximum fentanyl concentration was approximately 0.7 ng/mL from 32 to 72 h. Fentanyl plasma concentrations increased to 0.89 ng/mL 1 h after the patch was removed, and then decreased to a mean of 0.47 ng/mL at 80 h. The transdermal fentanyl patch is likely to provide some level of analgesia but should be initially co-administered with another faster acting analgesic for the first 12 h.

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“…It may be used for restraint or for sedation prior to administration of inhalation agents. Other regimens that have been investigated include medetomidine-midazolam-fentanyl (Baumgartner et al, 2010), and fentanyl-propofol (Baumgartner et al, 2009). Others administer fentanyl-fluanisone intramuscularly and follow with intravenous midazolam (Benato et al, 2013).…”

Section: Neuroleptanesthesia-neuroleptanalgesiamentioning

confidence: 99%

“…Baumgartner et al (2009) used propofol at 1.2-1.3 mg/kg/min IV after induction of anesthesia with 4-8 mg/kg IV. Baumgartner et al (2009) used propofol at 1.2-1.3 mg/kg/min IV after induction of anesthesia with 4-8 mg/kg IV.…”

Section: B Propofolmentioning

confidence: 99%