Cardiovascular Effects of Dobutamine and Converting Enzyme Inhibition in Rats with Diabetic Ketoacidosis

Abstract

We investigated cardiac and peripheral hemodynamics in rats with streptozotocin-induced diabetes mellitus in comparison to normal controls. Diabetic rats showed a significantly decreased cardiac output and heart rate, with unchanged mean blood pressures. Regional blood flows were unchanged except for renal blood flow which was significantly lower. The low output state associated with diabetes was reversed by angiotensin converting enzyme inhibition with MK-422, but not with dobutamine, although both agents caused similar reduction in peripheral vascular resistance. However, despite improved left ventricular performance, renal perfusion did not improve after MK-422.

INHIBITORY EFFECT OF ^|^beta;-HYDROXYBUTYRIC ACID ON L-TYPE Ca2+ CURRENT UNDER ^|^beta;-ADRENERGIC STIMULATION IN GUINEA PIG CARDIAC VENTRICULAR MYOCYTES

“…In rats, however, diabetic ketoacidosis decreased the heart rate and contractility 27) . In cardiac sinus node, atrium and atrio -ventricular node, Gi activation leads to opening of K + ACh channels and decreases the heart rate 28) .…”