Cardiovascular effects of cis-atracurium overdose in a dog following misplacement of neuromuscular monitoring electrodes

Jurado, Olga Martin; Mosing, Martina; Kutter, Annette P N; Boretti, Felicitas S; Bettschart‐Wolfensberger, Regula

doi:10.1111/j.1467-2995.2012.00730.x

Cited by 3 publications

(2 citation statements)

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“…Some studies in the literature have reported an increase in arterial pressure and heart rate after cis‐atracurium administration. Jurado, Mosing, Kutter, Boretti, and Bettschart‐Wolfensberger () observed increases in heart rate and mean arterial blood pressure in a dog after a cis‐atracurium overdose. Staffieri, Sleeper, and Larenza () also observed increases in arterial blood pressure and heart rate in dogs affected by X‐link muscular dystrophy.…”

Section: Discussionmentioning

confidence: 99%

“…These effects on M2 receptors could result in increases in heart rate and arterial blood pressure if high doses of cis‐atracurium are administered. Jurado et al., observed an increase in heart rate and arterial blood pressure when four boluses of 0.1 mg/kg cis‐atracurium were administered to a dog, achieving a final dose of 0.4 mg/kg. In the present study, doses of 1 mg/kg cis‐atracurium were needed to achieve a complete decrease in the TOF count and TOFR in the pigs.…”

Section: Discussionmentioning

confidence: 99%

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Neuromuscular block monitoring after the administration of 1 mg/kg intravenous cis‐atracurium in the anaesthetized pig

Aguilar

Moll

García

et al. 2018

Vet Pharm & Therapeutics

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Neuromuscular blocking agents should be included as part of a balanced anaesthetic protocol to improve anaesthetic management, although doses are not always established for each species. Cis-atracurium is a benzylisoquinolinium neuromuscular blocking agent with an intermediate duration of action devoid of significant adverse effects previously used in pigs with a wide dosage range. Cis-atracurium was administered at 1 mg/kg bolus to sixteen pigs to establish its time profile and effects. The pigs were premedicated intramuscularly with 4 mg/kg azaperone, 8 mg/kg ketamine and 0.2 mg/kg morphine IM and maintained with isoflurane in oxygen. After cis-atracurium administration, neuromuscular monitoring via acceleromyography was started until the recovery of the 90% of the train of four ratio. Complete decrease in the train of four ratio was accomplished in eleven pigs. Onset of action was 70 s, with a recovery of the fourth twitch at 26 min and a recovery of a train of four ratio greater than 90% in 60 min. In conclusion, 1 mg/kg intravenous cis-atracurium in the pig allowed for a rapid onset of action and a complete recovery after 60 min although high variability in the time profile is seen.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%