Cardiovascular effects of carbon dioxide in man

Cullen, David J.; Eger, E. I.

doi:10.1097/00006534-197506000-00077

Cited by 63 publications

(78 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3,39,40 Indeed, we observed large individual variability in cardiovascular reactivity (DABP/DEtCO2) to changes in EtCO2 during both hyperventilation and rebreathing (Tables 2 and 3, and Data Supplementary Table 1). However, assessment of changes in CVCi showed similar pattern as changes in CBFV during both hypo-and hypercapnic stimuli.…”

Section: Methodological Considerations and Study Limitationsmentioning

confidence: 85%

“…2 Notably, CVMR is likely to be determined by both the local effects of PaCO2 on the cerebral vasculature as well as the systemic effects on arterial blood pressure (ABP) (e.g., chemoreceptor-mediated blood pressure changes). 3 Thus, the assessment of CVMR should take into account the effects of concomitant changes in arterial pressure on CBF.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cerebral Vasomotor Reactivity during Hypo- and Hypercapnia in Sedentary Elderly and Masters Athletes

Zhu

Tarumi

Tseng

et al. 2013

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Physical activity may influence cerebrovascular function. The objective of this study was to determine the impact of life-long aerobic exercise training on cerebral vasomotor reactivity (CVMR) to changes in end-tidal CO2 (EtCO2) in older adults. Eleven sedentary young (SY, 27 ± 5 years), 10 sedentary elderly (SE, 72 ± 4 years), and 11 Masters athletes (MA, 72 ± 6 years) underwent the measurements of cerebral blood flow velocity (CBFV), arterial blood pressure, and EtCO2 during hypocapnic hyperventilation and hypercapnic rebreathing. Baseline CBFV was lower in SE and MA than in SY while no difference was observed between SE and MA. During hypocapnia, CVMR was lower in SE and MA compared with SY (1.87 ± 0.42 and 1.47 ± 0.21 vs. 2.18 ± 0.28 CBFV%/mm Hg, Po0.05) while being lowest in MA among all groups (Po0.05). In response to hypercapnia, SE and MA exhibited greater CVMR than SY (6.00 ± 0.94 and 6.67 ± 1.09 vs. 3.70 ± 1.08 CBFV1%/mm Hg, Po0.05) while no difference was observed between SE and MA. A negative linear correlation between hypo-and hypercapnic CVMR (R 2 ¼ 0.37, Po0.001) was observed across all groups. Advanced age was associated with lower resting CBFV and lower hypocapnic but greater hypercapnic CVMR. However, life-long aerobic exercise training appears to have minimal effects on these age-related differences in cerebral hemodynamics.

show abstract

Section: Methodological Considerations and Study Limitationsmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Cerebral Vasomotor Reactivity during Hypo- and Hypercapnia in Sedentary Elderly and Masters Athletes

Zhu

Tarumi

Tseng

et al. 2013

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

show abstract

“…Cardiac vasoconstriction may lead to coronary artery spasm, myocardial ischemia, arrhythmias, and tachycardia. 19 Alkalosis induces cerebral vasoconstriction, decreasing cerebral blood flow by 40 -50%. 20 Although used therapeutically in stroke victims to decrease intracranial pressure, inadvertently lowering CO 2 levels to Ͻ25 mm Hg may cause tetany and lead to further ischemic damage.…”

Section: Physiological Risks Associated With Manual Ventilationmentioning

confidence: 99%

Should a Portable Ventilator Be Used in All In-Hospital Transports?

Holets

Davies

2016

Respir Care

View full text Add to dashboard Cite

Movement of the mechanically ventilated patient may be for a routine procedure or medical emergency. The risks of transport seem manageable, but the memory of a respiratory-related catastrophe still gives many practitioners pause. The risk/benefit ratio of transport must be assessed before movement. During transport of the ventilated patients, should we always use a transport ventilator? What is the risk of using manual ventilation? How are PEEP and F IO 2 altered? Is there an impact on the ability to trigger during manual ventilation? Is hyperventilation and hypoventilation a common problem? Does hyperventilation or hypoventilation result in complications? Are portable ventilators worth the cost? What about the function of portable ventilators? Can these devices faithfully reproduce ICU ventilator function? The following pro and con discussion will attempt to address many of these issues by reviewing the current evidence on transport ventilation.

show abstract

“…The arterial CO 2 tension (PaCO 2 ) plays a role in regulating a variety of circulations such as cerebral, coronary and visceral circulations (Sokolo , 1960;Daugherty et al, 1967;Cullen & Eager, 1974;Hughes et al, 1979). Although an increase in PCO 2 generally induces vasodilation except the pulmonary vasculature (Hyde et al, 1964), the mechanism underlying the vasodilatory e ect of PCO 2 seems to be complex and remains to be clari®ed.…”

Section: Introductionmentioning

confidence: 99%

Involvement of barium‐sensitive K⁺ channels in endothelium‐dependent vasodilation produced by hypercapnia in rat mesenteric vascular beds

Okazaki

Endou

Okumura

1998

British J Pharmacology

View full text Add to dashboard Cite

1 We examined the vasodilatory e ect of hypercapnia in the rat isolated mesenteric vascular bed. The preparation was perfused constantly (5 ml min 71 with oxygenated Krebs-Ringer solution, and the perfusion pressure was measured. In order to keep the extracellular pH (pHe) constant (around 7.35) against a change in CO 2 , adequate amounts of NaHCO 3 were added to Krebs-Ringer solution. 2 In the endothelium intact preparations, an increase in CO 2 from 2.5% to 10% in increments of 2.5% decreased the 10 mM phenylephrine (PE)-produced increase in the perfusion pressure in a concentrationdependent manner. Denudation of the endothelium by CHAPS (3-[(3-cholamidopropyl)-dimethylammonio]-l-propanesulphonate) (5 mg l 71 , 90 s perfusion) abolished the vasodilatory e ect of hypercapnia. 3 An increase in CO 2 from 5% to 10% reduced the increases in the perfusion pressure produced by 10 mM PE and 400 nM U-46619 by 48% and 44%, respectively. N G -monomethyl-L-arginine (100 mM) and indomethacin (10 mM) did not a ect the vasodilatory e ect of hypercapnia, whereas the vasodilatory response of the preparation to hypercapnia disappeared when the preparation was contracted by 60 mM K + instead of PE or U-46619. 4 The vasodilatory e ect of hypercapnia observed in the PE-or U-46619-precontracted preparation was a ected by neither tetraethylammonium (1 mM), apamin (500 mM), glibenclamide (10 mM), nor 4-aminopyridine (1.5 mM). On the other hand, pretreatment with Ba 2+ at a concentration of 0.3 mM abolished the hypercapnia-produced vasodilation. 5 An increase in the concentration of K + in Krebs-Ringer solution from 4.5 mM to 12.5 mM in increments of 2 mM reduced the PE-produced increase in the perfusion pressure in a concentrationdependent manner. Pretreatment of the preparations with not only Ba 2+ (0.3 mM) but also CHAPS abolished the vasodilatory e ect of K + . 6 The results suggest that an increase in CO 2 produces vasodilation by an endothelium-dependent mechanism in the rat mesenteric vascular bed. The membrane hyperpolarization of the endothelial cell by an activation of the inward recti®er K + channel seems to be the mechanism underlying the hypercapnia-produced vasodilation. Neither nitric oxide nor prostaglandins are involved in this response.

show abstract

Cardiovascular effects of carbon dioxide in man

Cited by 63 publications

References 0 publications

Cerebral Vasomotor Reactivity during Hypo- and Hypercapnia in Sedentary Elderly and Masters Athletes

Cerebral Vasomotor Reactivity during Hypo- and Hypercapnia in Sedentary Elderly and Masters Athletes

Should a Portable Ventilator Be Used in All In-Hospital Transports?

Involvement of barium‐sensitive K⁺ channels in endothelium‐dependent vasodilation produced by hypercapnia in rat mesenteric vascular beds

Contact Info

Product

Resources

About

Cardiovascular effects of carbon dioxide in man

Cited by 63 publications

References 0 publications

Cerebral Vasomotor Reactivity during Hypo- and Hypercapnia in Sedentary Elderly and Masters Athletes

Cerebral Vasomotor Reactivity during Hypo- and Hypercapnia in Sedentary Elderly and Masters Athletes

Should a Portable Ventilator Be Used in All In-Hospital Transports?

Involvement of barium‐sensitive K+ channels in endothelium‐dependent vasodilation produced by hypercapnia in rat mesenteric vascular beds

Contact Info

Product

Resources

About

Involvement of barium‐sensitive K⁺ channels in endothelium‐dependent vasodilation produced by hypercapnia in rat mesenteric vascular beds