Cardiovascular Effects of Androgens

Wilson, Carlos Pizarro; Maass, Rodrigo; Estrada, Manuel

doi:10.5772/17843

Cited by 5 publications

(4 citation statements)

References 70 publications

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“…Androgen production progressively decline by two different mechanisms: (i) the adrenal glands produce progressively less DHEA and DHEAS; (ii) testosterone levels gradually decline most likely due to reduced ovarian production. This is in contrast with the sudden drop in oestrogen at menopause . During menopausal transition, the environment become more androgenic, because of a transient increase of total testosterone levels in the final menstrual period, compared to the years before.…”

Section: Androgenmentioning

confidence: 88%

“…The androgen receptor (AR) is a member of sex‐steroid hormone superfamily receptors, activated by the binding of androgenic hormones testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus. Androgen receptor is most closely related to the PR, and progestins in higher dosages can block it . Even testosterone, as well as oestrogen, performs its biological effects through the genomic and nongenomic modulation of cells functions (Table ; Fig.…”

Section: Androgenmentioning

confidence: 99%

“…Androgen receptor is most closely related to the PR, and progestins in higher dosages can block it . Even testosterone, as well as oestrogen, performs its biological effects through the genomic and nongenomic modulation of cells functions (Table ; Fig. ).…”

Section: Androgenmentioning

confidence: 99%

“…The reduction of SHBG is associated with increased circulating free testosterone values . Some authors observed also a transient gender‐specific rise in DHEAS levels during the time of menopausal transition in women, with the consequent increase in testosterone production . High testosterone levels have been associated with an increased risk of CVD, insulin resistance and worse lipid profile .…”

Section: Androgenmentioning

confidence: 99%

See 3 more Smart Citations

The different role of sex hormones on female cardiovascular physiology and function: not only oestrogens

Salerni

Francescomarino

Dessalvi

et al. 2015

Eur J Clin Investigation

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Human response to different physiologic stimuli and cardiovascular (CV) adaptation to various pathologies seem to be gender specific. Sex-steroid hormones have been postulated as the major contributors towards these sexrelated differences. This review will discuss current evidence on gender differences in CV function and remodelling, and will present the different role of the principal sex-steroid hormones on female heart. Starting from a review of sex hormones synthesis, receptors and CV signalling, we will summarize the current knowledge concerning the role of sex hormones on the regulation of our daily activities throughout the life, via the modulation of autonomic nervous system, excitation-contraction coupling pathway and ion channels activity. Many unresolved questions remain even if oestrogen effects on myocardial remodelling and function have been extensively studied. So this work will focus attention also on the controversial and complex relationship existing between androgens, progesterone and female heart.

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Section: Androgenmentioning

confidence: 88%

Section: Androgenmentioning

confidence: 99%

Section: Androgenmentioning

confidence: 99%

Section: Androgenmentioning

confidence: 99%

See 2 more Smart Citations

The different role of sex hormones on female cardiovascular physiology and function: not only oestrogens

Salerni

Francescomarino

Dessalvi

et al. 2015

Eur J Clin Investigation

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The Effects of Sex Steroid Hormones on Cardiovascular Physiology in Females

Tegg,

Myburgh,

Norris

2023

Advances in Biochemistry in Health and Disease

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Assessment of cardiac function in children with congenital adrenal hyperplasia: a case control study in Cameroon

Nengom

Chelo

et al. 2017

BMC Pediatr

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BackgroundHigh level of androgens found in congenital adrenal hyperplasia (CAH) seems to have a deleterious effect on heart function. We therefore evaluate cardiac function of children with CAH in comparison with a healthy group.MethodsWe carried out a case-control study in the single endocrinology unit of the Mother and Child Center of Chantal Biya’s Foundation. Cases were matched for age and genotypic sex to 2 healthy controls. We analyzed the ejection fraction (LVEF), fractional shortening and left ventricular mass; output and cardiac index; E and A waves velocities, E/A ratio and the mitral deceleration time and diameter of the left atrium; tricuspid annular plane systolic excursion and pulmonary artery systolic pressure were also measured.ResultsWe included 19 patients with a median age of 6.26 ± 3.75 years and 38 controls stackable distribution. The left ventricular mass of cases was greater than that of controls. A case of reversible cardiomyopathy on hormone replacement therapy was found.For the cases, the average ejection fraction was 71.95 ± 7.88%; the average fractional shortening was 40.67 ± 7.02%. All these values were higher than those of controls, although the difference was not statistically significant. Diastolic left ventricular function was more impaired among the cases.Right ventricular function was similar in both groups. These abnormalities were highly correlated to the late age at diagnosis and duration of treatment.ConclusionThis study shows an altered cardiac function in CAH compared to healthy control and highlights importance of an early diagnosis of cases, a tight control of androgens levels and a regular monitoring of cardiac function.

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Cardiovascular Effects of Androgens

Cited by 5 publications

References 70 publications

The different role of sex hormones on female cardiovascular physiology and function: not only oestrogens

The different role of sex hormones on female cardiovascular physiology and function: not only oestrogens

The Effects of Sex Steroid Hormones on Cardiovascular Physiology in Females

Assessment of cardiac function in children with congenital adrenal hyperplasia: a case control study in Cameroon

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