Cardiovascular effects induced by α‐terpineol in hypertensive rats

Abstract

The antihypertensive and antioxidant effects of α‐terpineol on hypertensive rats were evaluated in this study. Hypertension was induced in male Wistar rats by oral administration of the NG‐nitro‐L‐arginine methyl ester (L‐NAME) 50 mg/kg body weight/day) in drinking water for 1 week. Rats with mean arterial pressure > 140 mmHg were considered hypertensive. In order to evaluate the α‐terpineol effect on haemodynamic parameters, rats were treated once a day with different doses of α‐terpineol (25, 50, or 100 mg/kg/day) or vehicle for one week. After this time, blood samples were collected and activities of antioxidant enzymes were assessed. Furthermore, the vasorelaxant effect of α‐terpineol was also assessed in mesenteric artery rings. Oral administration of α‐terpineol was able to reduce mean arterial pressure in up to 38.15 ± 8.7 mmHg. In mesenteric artery rings, α‐terpineol (10−9–10−2 M) induced vascular endothelium independent vasodilatation. In addition, rats treated with α‐terpineol showed alterations in biochemical parameters indicating an antioxidant effect. Such results suggest that α‐terpineol is able to reduce arterial pressure, possibly due to a decrease of vascular resistance, and restore enzymatic antioxidants in L‐NAME‐induced hypertensive rats. Copyright © 2013 John Wiley & Sons, Ltd.

Gas Chromatography-Triple Quadrupole Mass Spectrometry Analysis and Vasorelaxant Effect of Essential Oil fromProtium heptaphyllum(Aubl.) March.

“…Of the 23 monoterpenes identified in this species, five of them had already been studied for their effects on the cardiovascular system: p -cymene, eucalyptol, linalool, α -pinene, limonene, and α -terpineol. The main effects observed were hypotension and bradycardia in vivo to p -cymene [ 37 ], negative inotropic effect in vivo to eucalyptol [ 38 ], cardiovascular system stimulation and depression in vivo to linalool [ 39 ], reduction and prevention of cardiovascular injuries caused by pulmonary hypertension in vivo to limonene [ 40 ], and hypotension and vasorelaxation [ 41 ] and antihypertension to terpineol [ 42 ]. This paper showed that essential oils may be considered promising agents for prevention or treatment of diseases of the cardiovascular system.…”

Chemical Composition and Antioxidant Activity of Solenostemma oleifolium Essential Oil from Southern Algeria

“…It has been proven that linalool reduces the levels of nuclear factor-erythroid. 16 In addition, linalool was found to be effective as an antioxidant in guinea pig brains injected with H 2 O 2 . 14 As it was previously mentioned, α-terpineol proved to possess a potent antioxidant activity against free radicals causing injury.…”

Cardiovascular Activity of the Chemical Constituents of Essential Oils

“…The in vivo effect of the monoterpene α-terpineol was evaluated by Sabino et al [ 80 ] who used the model of hypertension induced by l -NAME. Therefore, it was demonstrated that α-terpineol was capable of inducing a dose-dependent hypotension in awake animals.…”